ClinicalTrials.gov record
Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
ClinicalTrials.gov ID: NCT03785249
Public ClinicalTrials.gov record NCT03785249. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 3:36 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation KRYSTAL-1
Study identification
- NCT ID
- NCT03785249
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Mirati Therapeutics Inc.
- Industry
- Enrollment
- 731 participants
Conditions and interventions
Interventions
- Afatinib Drug
- Cetuximab Drug
- MRTX849 Drug
- Pembrolizumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 14, 2019
- Primary completion
- Dec 30, 2026
- Completion
- Dec 30, 2026
- Last update posted
- Sep 29, 2025
2019 – 2026
United States locations
- U.S. sites
- 221
- U.S. states
- 36
- U.S. cities
- 159
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 001-826 | Birmingham | Alabama | 35294 | — |
| Local Institution - 001-965 | Anchorage | Alaska | 99508 | — |
| Local Institution - 001-821 | Phoenix | Arizona | 85054 | — |
| Local Institution - 001-873-A | Tucson | Arizona | 85704 | — |
| Local Institution - 001-873 | Tucson | Arizona | 85704 | — |
| Local Institution - 001-840-B | Bellflower | California | 90706 | — |
| Local Institution - 001-834 | Beverly Hills | California | 90211 | — |
| Local Institution - 001-843 | Duarte | California | 91010 | — |
| Local Institution - 001-850-K | Dublin | California | 94568 | — |
| Local Institution - 001-851 | Fullerton | California | 92835 | — |
| Local Institution - 001-840-C | Harbor City | California | 90710 | — |
| Local Institution - 001-805 | La Jolla | California | 92093 | — |
| Local Institution - 001-779 | Los Alamitos | California | 90720 | — |
| Local Institution - 001-840 | Los Angeles | California | 90027 | — |
| Local Institution - 001-578 | Los Angeles | California | 90067 | — |
| Local Institution - 001-847 | Newport Beach | California | 92663 | — |
| Local Institution - 001-850-B | Oakland | California | 94611 | — |
| Local Institution - 001-803 | Orange | California | 92868 | — |
| Local Institution - 001-850-C | Roseville | California | 95661 | — |
| Local Institution - 001-850-J | Sacramento | California | 95814 | — |
| Local Institution - 001-850-D | Sacramento | California | 95825 | — |
| Local Institution - 001-845 | San Diego | California | 92111 | — |
| Local Institution - 001-840-A | San Diego | California | 92120 | — |
| Local Institution - 001-850-H | San Francisco | California | 94080 | — |
| Local Institution - 001-850-E | San Francisco | California | 94115 | — |
| Local Institution - 001-850-F | San Jose | California | 95119 | — |
| Local Institution - 001-850-A | San Leandro | California | 94577 | — |
| Local Institution - 001-884 | Santa Barbara | California | 93105 | — |
| Local Institution - 001-850-I | Santa Clara | California | 95051 | — |
| Local Institution - 001-884-A | Solvang | California | 93463 | — |
| Local Institution - 001-850 | Vallejo | California | 94589 | — |
| Local Institution - 001-850-G | Walnut Creek | California | 94596 | — |
| Local Institution - 001-872 | Aurora | Colorado | 80012 | — |
| Local Institution - 001-810 | Aurora | Colorado | 80045 | — |
| Local Institution - 001-872-H | Boulder | Colorado | 80303 | — |
| Local Institution - 001-872-E | Colorado Springs | Colorado | 80907 | — |
| Local Institution - 001-872-L | Colorado Springs | Colorado | 80920 | — |
| Local Institution - 001-872-B | Denver | Colorado | 80218 | — |
| Local Institution - 001-951 - A | Denver | Colorado | 80218 | — |
| Local Institution - 001-951 - B | Denver | Colorado | 80218 | — |
| Local Institution - 001-846 | Grand Junction | Colorado | 81501 | — |
| Local Institution - 001-951 | Lafayette | Colorado | 80026 | — |
| Local Institution - 001-872-A | Lakewood | Colorado | 80228 | — |
| Local Institution - 001-872-D | Littleton | Colorado | 80218 | — |
| Local Institution - 001-872-K | Lone Tree | Colorado | 80124 | — |
| Local Institution - 001-872-C | Longmont | Colorado | 80501 | — |
| Local Institution - 001-872-J | Parker | Colorado | 80138 | — |
| Local Institution - 001-872-F | Pueblo | Colorado | 81008 | — |
| Local Institution - 001-872-G | Pueblo | Colorado | 81008 | — |
| Local Institution - 001-872-I | Thornton | Colorado | 80260 | — |
| Local Institution - 001-816 | New Haven | Connecticut | 06510 | — |
| Local Institution - 001-871 | Newark | Delaware | 19713-2055 | — |
| Local Institution - 001-929i | Altamonte Springs | Florida | 32701 | — |
| Local Institution - 001-839 | Boca Raton | Florida | 33432 | — |
| Local Institution - 001-922A | Bonita Springs | Florida | 34135 | — |
| Local Institution - 001-922D | Bradenton | Florida | 34211 | — |
| Local Institution - 001-929c | Brandon | Florida | 33511 | — |
| Local Institution - 001-922E | Cape Coral | Florida | 33909 | — |
| Local Institution - 001-929g | Clearwater | Florida | 33761 | — |
| Local Institution - 001-926b | Daytona Beach | Florida | 32117 | — |
| Local Institution - 001-922 | Fort Myers | Florida | 33901 | — |
| Local Institution - 001-922B | Fort Myers | Florida | 33905 | — |
| Local Institution - 001-922C | Fort Myers | Florida | 33908 | — |
| Local Institution - 001-929b | Gainesville | Florida | 32605 | — |
| Local Institution - 001-829 | Jacksonville | Florida | 32224 | — |
| Local Institution - 001-929m | Lady Lake | Florida | 32159 | — |
| Local Institution - 001-929e | Largo | Florida | 33770 | — |
| Local Institution - 001-929n | Lecanto | Florida | 34461 | — |
| Local Institution - 001-870 | Miami | Florida | 33176 | — |
| Local Institution - 001-825 | Miami Beach | Florida | 33140 | — |
| Local Institution - 001-922F | Naples | Florida | 34102 | — |
| Local Institution - 001-922G | Naples | Florida | 34102 | — |
| Local Institution - 001-538 | Ocala | Florida | 34474 | — |
| Local Institution - 001-929p | Ocala | Florida | 34474 | — |
| Local Institution - 001-914 | Orange City | Florida | 32763 | — |
| Local Institution - 001-929j | Orange City | Florida | 32763 | — |
| Local Institution - 001-929l | Orlando | Florida | 32806 | — |
| Local Institution - 001-877 | Pensacola | Florida | 32503 | — |
| Local Institution - 001-922H | Port Charlotte | Florida | 33980 | — |
| Local Institution - 001-922I | Sarasota | Florida | 34232 | — |
| Local Institution - 001-922J | Sarasota | Florida | 34236 | — |
| Local Institution - 001-929h | Spring Hill | Florida | 34608 | — |
| Local Institution - 001-929a | St. Petersburg | Florida | 33705 | — |
| Local Institution - 001-929 | St. Petersburg | Florida | 33705 | — |
| Local Institution - 001-926d | Stuart | Florida | 34994 | — |
| Local Institution - 001-929d | Tampa | Florida | 33607 | — |
| Local Institution - 001-929k | Tavares | Florida | 32778 | — |
| Local Institution - 001-929f | Trinity | Florida | 34655 | — |
| Local Institution - 001-922K | Venice | Florida | 34285 | — |
| Local Institution - 001-922L | Venice | Florida | 34292 | — |
| Local Institution - 001-926c | Vero Beach | Florida | 32960 | — |
| Local Institution - 001-926a | Wellington | Florida | 33414 | — |
| Local Institution - 001-926 | West Palm Beach | Florida | 33401 | — |
| Local Institution - 001-929o | Winter Park | Florida | 32789 | — |
| Local Institution - 001-967 | Athens | Georgia | 30607 | — |
| Local Institution - 001-835-C | Austell | Georgia | 30106 | — |
| Local Institution - 001-835-E | Austell | Georgia | 30106 | — |
| Local Institution - 001-835-D | Carrollton | Georgia | 30117 | — |
| Local Institution - 001-835-F | Carrollton | Georgia | 30117 | — |
| Local Institution - 001-835-A | Cartersville | Georgia | 30121 | — |
| Local Institution - 001-835-B | Douglasville | Georgia | 30134 | — |
| Local Institution - 001-835 | Marietta | Georgia | 30060 | — |
| Local Institution - 001-862 | Chicago Ridge | Illinois | 60415 | — |
| Local Institution - 001-883 | Niles | Illinois | 60714 | — |
| Local Institution - 001-781 | South Bend | Indiana | 46601 | — |
| Local Institution - 001-831 | Iowa City | Iowa | 52242 | — |
| Local Institution - 001-820 | Westwood | Kansas | 66205 | — |
| Local Institution - 001-844 | Lexington | Kentucky | 40536 | — |
| Local Institution - 001-920 | Baton Rouge | Louisiana | 70809 | — |
| Local Institution - 001-827 | Biddeford | Maine | 04005 | — |
| Local Institution - 001-881-B | Brandywine | Maryland | 20613 | — |
| Local Institution - 001-881 | Columbia | Maryland | 21044 | — |
| Local Institution - 001-881-A | Silver Spring | Maryland | 20904 | — |
| Local Institution - 001-808 | Boston | Massachusetts | 02215 | — |
| Local Institution - 001-842 | Detroit | Michigan | 48201 | — |
| Local Institution - 001-811 | Detroit | Michigan | 48202 | — |
| Local Institution - 001-842-A | Farmington Hills | Michigan | 48334 | — |
| Local Institution - 001-838-F | Coon Rapids | Minnesota | 55433 | — |
| Local Institution - 001-838-E | Edina | Minnesota | 55435 | — |
| Local Institution - 001-875 - D | Edina | Minnesota | 55435 | — |
| Local Institution - 001-838-D | Maplewood | Minnesota | 55109 | — |
| Local Institution - 001-875 - A | Maplewood | Minnesota | 55109 | — |
| Local Institution - 001-838-C | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 001-875 | Minneapolis | Minnesota | 55404 | — |
| Local Institution - 001-838-G | Minneapolis | Minnesota | 55415 | — |
| Local Institution - 001-822-A | Minneapolis | Minnesota | 55455 | — |
| Local Institution - 001-822 | Minneapolis | Minnesota | 55455 | — |
| Local Institution - 001-830 | Rochester | Minnesota | 55905 | — |
| Local Institution - 001-838 | Saint Louis Park | Minnesota | 55416 | — |
| Local Institution - 001-838-B | Saint Louis Park | Minnesota | 55426-5000 | — |
| Local Institution - 001-838-A | Saint Paul | Minnesota | 55101 | — |
| Local Institution - 001-875 - B | Saint Paul | Minnesota | 55102 | — |
| Local Institution - 001-875 - C | Woodbury | Minnesota | 55125 | — |
| Local Institution - 001-952 | Bolivar | Missouri | 65613 | — |
| Local Institution - 001-950 | Jefferson City | Missouri | 65109 | — |
| Local Institution - 001-841 | Billings | Montana | 59102 | — |
| Local Institution - 001-544B | Omaha | Nebraska | 68105-1850 | — |
| Local Institution - 001-959 | Omaha | Nebraska | 68114 | — |
| Local Institution - 001-544A | Omaha | Nebraska | 68118 | — |
| Local Institution - 001-544 | Omaha | Nebraska | 68198 | — |
| Local Institution - 001-860A | Henderson | Nevada | 89052 | — |
| Local Institution - 001-860C | Henderson | Nevada | 89052 | — |
| Local Institution - 001-860B | Henderson | Nevada | 89074 | — |
| Local Institution - 001-860 | Henderson | Nevada | 89074 | — |
| Local Institution - 001-860E | Las Vegas | Nevada | 89128 | — |
| Local Institution - 001-860D | Las Vegas | Nevada | 89144 | — |
| Local Institution - 001-860F | Las Vegas | Nevada | 89148 | — |
| Local Institution - 001-861 | Albany | New York | 12206 | — |
| Local Institution - 001-815 | Buffalo | New York | 14203 | — |
| Local Institution - 001-813 | New York | New York | 10016 | — |
| Local Institution - 001-806 | New York | New York | 10065 | — |
| Local Institution - 001-812 | Chapel Hill | North Carolina | 27514 | — |
| Local Institution - 001-971 | Pinehurst | North Carolina | 28374 | — |
| Local Institution - 001-966 | Cincinnati | Ohio | 45219 | — |
| Local Institution - 001-823 | Cincinnati | Ohio | 45267 | — |
| Local Institution - 001-818 | Cleveland | Ohio | 44195 | — |
| Local Institution - 001-833 - H | Columbus | Ohio | 43201 | — |
| Local Institution - 001-833 - C | Columbus | Ohio | 43203 | — |
| Local Institution - 001-833 - J | Columbus | Ohio | 43203 | — |
| Local Institution - 001-833 - A | Columbus | Ohio | 43210 | — |
| Local Institution - 001-833 - F | Columbus | Ohio | 43210 | — |
| Local Institution - 001-833 | Columbus | Ohio | 43210 | — |
| Local Institution - 001-833 - D | Columbus | Ohio | 43212 | — |
| Local Institution - 001-833 - I | Columbus | Ohio | 43212 | — |
| Local Institution - 001-930 | Columbus | Ohio | 43219 | — |
| Local Institution - 001-833 - B | Columbus | Ohio | 43221 | — |
| Local Institution - 001-833 - G | Columbus | Ohio | 43221 | — |
| Local Institution - 001-833 - E | Gahanna | Ohio | 43230 | — |
| Local Institution - 001-836-A | Kettering | Ohio | 45429 | — |
| Local Institution - 001-836 | Kettering | Ohio | 45429 | — |
| Local Institution - 001-600 | Lawton | Oklahoma | 73505 | — |
| Local Institution - 001-584 | Tulsa | Oklahoma | 74146 | — |
| Local Institution - 001-586-A | Bend | Oregon | 97701 | — |
| Local Institution - 001-586 | Bend | Oregon | 97701 | — |
| Local Institution - 001-889 | Eugene | Oregon | 97401 | — |
| Local Institution - 001-837 | Allentown | Pennsylvania | 18103 | — |
| Local Institution - 001-837-A | Bethlehem | Pennsylvania | 18017 | — |
| Local Institution - 001-817 | Hershey | Pennsylvania | 17033-0850 | — |
| Local Institution - 001-783 | Media | Pennsylvania | 19063 | — |
| Local Institution - 001-887 | Charleston | South Carolina | 29414 | — |
| Local Institution - 001-819 | Charleston | South Carolina | 29425 | — |
| Local Institution - 001-801-G | Gallatin | Tennessee | 37066 | — |
| Local Institution - 001-801-A | Hendersonville | Tennessee | 37075 | — |
| Local Institution - 001-801-D | Hermitage | Tennessee | 37076 | — |
| Local Institution - 001-801-F | Murfreesboro | Tennessee | 37129 | — |
| Local Institution - 001-801-B | Nashville | Tennessee | 37203 | — |
| Local Institution - 001-801 | Nashville | Tennessee | 37203 | — |
| Local Institution - 001-801-E | Nashville | Tennessee | 37207 | — |
| Local Institution - 001-801-C | Nashville | Tennessee | 37211 | — |
| Local Institution - 001-888-B | Arlington | Texas | 76012 | — |
| Local Institution - 001-888 | Arlington | Texas | 76012 | — |
| Local Institution - 001-880 | Austin | Texas | 78731 | — |
| Local Institution - 001-848a | Conroe | Texas | 77384 | — |
| Local Institution - 001-809 | Dallas | Texas | 75230 | — |
| Local Institution - 001-886 | Dallas | Texas | 75231 | — |
| Local Institution - 001-879 | Dallas | Texas | 75246 | — |
| Local Institution - 001-785 | Denison | Texas | 75020 | — |
| Local Institution - 001-876 | Fort Worth | Texas | 76104 | — |
| Local Institution - 001-848 | Houston | Texas | 77030 | — |
| Local Institution - 001-969 | Houston | Texas | 77030 | — |
| Local Institution - 001-935A | Houston | Texas | 77090 | — |
| Local Institution - 001-999 | Irving | Texas | 75063 | — |
| Local Institution - 001-935D | Kingwood | Texas | 77339 | — |
| Local Institution - 001-935 | Kingwood | Texas | 77339 | — |
| Local Institution - 001-554 | Midland | Texas | 79701 | — |
| Local Institution - 001-802 | San Antonio | Texas | 78229 | — |
| Local Institution - 001-935B | Shenandoah | Texas | 77380 | — |
| Local Institution - 001-935C | Spring | Texas | 77389 | — |
| Local Institution - 001-874 | Sugar Land | Texas | 77479 | — |
| Local Institution - 001-935E | Tomball | Texas | 77375 | — |
| Local Institution - 001-878 | Tyler | Texas | 75702 | — |
| Local Institution - 001-890 | Waco | Texas | 76712 | — |
| Local Institution - 001-814 | Fairfax | Virginia | 22031 | — |
| Local Institution - 001-597 | Fredericksburg | Virginia | 24408 | — |
| Local Institution - 001-882 | Newport News | Virginia | 23606 | — |
| Local Institution - 001-882-A | Norfolk | Virginia | 23502 | — |
| Local Institution - 001-890-A | Norfolk | Virginia | 23502 | — |
| Local Institution - 001-968 | Richmond | Virginia | 23229 | — |
| Local Institution - 001-824 | Seattle | Washington | 98109 | — |
| Local Institution - 001-885 | Vancouver | Washington | 98684 | — |
| Local Institution - 001-804 | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03785249, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 29, 2025 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03785249 live on ClinicalTrials.gov.