ClinicalTrials.gov record
Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer
ClinicalTrials.gov ID: NCT03801876
Public ClinicalTrials.gov record NCT03801876. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial studies how well proton beam radiation therapy compared with intensity modulated photon radiotherapy works in treating patients with stage I-IVA esophageal cancer. Proton beam radiation therapy uses a beam of protons (rather than x-rays) to send radiation inside the body to the tumor without damaging much of the healthy tissue around it. Intensity modulated photon radiotherapy uses high-energy x-rays to deliver radiation directly to the tumor without damaging much of the healthy tissue around it. It is not yet known whether proton beam therapy or intensity modulated photon radiotherapy will work better in treating patients with esophageal cancer.
Study identification
- NCT ID
- NCT03801876
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 300 participants
Conditions and interventions
Conditions
- Clinical Stage I Esophageal Adenocarcinoma AJCC v8
- Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8
- Clinical Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage II Esophageal Adenocarcinoma AJCC v8
- Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC v8
- Clinical Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage III Esophageal Adenocarcinoma AJCC v8
- Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8
- Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8
- Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
- Clinical Stage IVA Esophageal Squamous Cell Carcinoma AJCC v8
- Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8
- Thoracic Esophagus Squamous Cell Carcinoma
Interventions
- Biospecimen Collection Procedure
- Capecitabine Drug
- Carboplatin Drug
- Computed Tomography Procedure
- Docetaxel Drug
- Esophagectomy Procedure
- Fluorouracil Drug
- Intensity-Modulated Radiation Therapy Radiation
- Leucovorin Calcium Drug
- Oxaliplatin Drug
- Paclitaxel Drug
- Positron Emission Tomography Procedure
- Proton Beam Radiation Therapy Radiation
- Quality-of-Life Assessment Other
- Questionnaire Administration Other
Procedure · Drug · Radiation + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 25, 2019
- Primary completion
- Nov 6, 2031
- Completion
- Nov 6, 2036
- Last update posted
- Aug 23, 2026
2019 – 2036
United States locations
- U.S. sites
- 96
- U.S. states
- 21
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| UM Sylvester Comprehensive Cancer Center at Doral | Doral | Florida | 33166 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Miami Cancer Institute | Miami | Florida | 33176 | — |
| UM Sylvester Comprehensive Cancer Center at Kendall | Miami | Florida | 33176 | — |
| Orlando Health Cancer Institute | Orlando | Florida | 32806 | — |
| UM Sylvester Comprehensive Cancer Center at Plantation | Plantation | Florida | 33324 | — |
| Emory Proton Therapy Center | Atlanta | Georgia | 30308 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Alton Memorial Hospital | Alton | Illinois | 62002 | — |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | — |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | — |
| Memorial Hospital East | Shiloh | Illinois | 62269 | — |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | — |
| Maryland Proton Treatment Center | Baltimore | Maryland | 21201 | — |
| University of Maryland/Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| UM Upper Chesapeake Medical Center | Bel Air | Maryland | 21014 | — |
| Massachusetts General Hospital Cancer Center | Boston | Massachusetts | 02114 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Corewell Health Dearborn Hospital | Dearborn | Michigan | 48124 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | — |
| McLaren Cancer Institute-Lapeer Region | Lapeer | Michigan | 48446 | — |
| McLaren Cancer Institute-Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| McLaren Cancer Institute-Owosso | Owosso | Michigan | 48867 | — |
| Corewell Health William Beaumont University Hospital | Royal Oak | Michigan | 48073 | — |
| Corewell Health Beaumont Troy Hospital | Troy | Michigan | 48085 | — |
| Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota | 56007 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Mayo Clinic Health Systems-Mankato | Mankato | Minnesota | 56001 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Mayo Clinic Radiation Therapy-Northfield | Northfield | Minnesota | 55057 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Siteman Cancer Center at Saint Peters Hospital | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center at West County Hospital | Creve Coeur | Missouri | 63141 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Siteman Cancer Center-South County | St Louis | Missouri | 63129 | — |
| Siteman Cancer Center at Christian Hospital | St Louis | Missouri | 63136 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Memorial Sloan Kettering Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Memorial Sloan Kettering Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Bergen | Montvale | New Jersey | 07645 | — |
| Memorial Sloan Kettering Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Westchester | Harrison | New York | 10604 | — |
| New York Proton Center | New York | New York | 10035 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Memorial Sloan Kettering Nassau | Uniondale | New York | 11553 | — |
| UH Seidman Cancer Center at UH Avon Health Center | Avon | Ohio | 44011 | — |
| UHHS-Chagrin Highlands Medical Center | Beachwood | Ohio | 44122 | — |
| Geauga Hospital | Chardon | Ohio | 44024 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Case Western Reserve University | Cleveland | Ohio | 44106 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Mercy Cancer Center-Elyria | Elyria | Ohio | 44035 | — |
| UH Seidman Cancer Center at Landerbrook Health Center | Mayfield Heights | Ohio | 44124 | — |
| UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor | Ohio | 44060 | — |
| UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights | Ohio | 44130 | — |
| University Hospitals Parma Medical Center | Parma | Ohio | 44129 | — |
| University Hospitals Portage Medical Center | Ravenna | Ohio | 44266 | — |
| UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky | Ohio | 44870 | — |
| University Hospitals Sharon Health Center | Wadsworth | Ohio | 44281 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| UH Seidman Cancer Center at Saint John Medical Center | Westlake | Ohio | 44145 | — |
| UHHS-Westlake Medical Center | Westlake | Ohio | 44145 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| University of Pennsylvania/Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | — |
| Covenant Health Proton Center | Knoxville | Tennessee | 37909 | — |
| Covenant Health Cancer Centers | Knoxville | Tennessee | 37916 | — |
| Covenant Health Cancer Centers - West | Knoxville | Tennessee | 37932 | — |
| Covenant Health Oncology Group - Maryville | Maryville | Tennessee | 37804 | — |
| Covenant Health Oncology Group - Oak Ridge | Oak Ridge | Tennessee | 37830 | — |
| MD Anderson in The Woodlands | Conroe | Texas | 77384 | — |
| UT MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| MD Anderson West Houston | Houston | Texas | 77079 | — |
| UT MD Anderson - League City | League City | Texas | 77573 | — |
| MD Anderson in Sugar Land | Sugar Land | Texas | 77478 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| Inova Alexandria Hospital | Alexandria | Virginia | 22304 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Inova Fair Oaks Hospital | Fairfax | Virginia | 22033 | — |
| Inova Loudoun Hospital | Leesburg | Virginia | 20176 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| Mayo Clinic Health System-Eau Claire Clinic | Eau Claire | Wisconsin | 54701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03801876, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03801876 live on ClinicalTrials.gov.