Comparing Proton Therapy to Photon Radiation Therapy for Esophageal Cancer

ClinicalTrials.gov ID: NCT03801876

Public ClinicalTrials.gov record NCT03801876. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:36 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase III Randomized Trial of Proton Beam Therapy (PBT) Versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer

Study identification

NCT ID: NCT03801876
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: NRG Oncology; Other
Enrollment: 300 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Capecitabine Drug
Carboplatin Drug
Computed Tomography Procedure
Docetaxel Drug
Esophagectomy Procedure
Fluorouracil Drug
Intensity-Modulated Radiation Therapy Radiation
Leucovorin Calcium Drug
Oxaliplatin Drug
Paclitaxel Drug
Positron Emission Tomography Procedure
Proton Beam Radiation Therapy Radiation
Quality-of-Life Assessment Other
Questionnaire Administration Other

Procedure · Drug · Radiation + 1 more

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 25, 2019
Primary completion: Dec 20, 2026
Completion: Dec 20, 2031
Last update posted: May 6, 2026

2019 – 2031

United States locations

U.S. sites: 95
U.S. states: 21
U.S. cities: 79

Facility	City	State	ZIP	Site status
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Active, not recruiting
Mayo Clinic in Arizona	Scottsdale	Arizona	85259	Active, not recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
UM Sylvester Comprehensive Cancer Center at Doral	Doral	Florida	33166	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
Miami Cancer Institute	Miami	Florida	33176	Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall	Miami	Florida	33176	Recruiting
Orlando Health Cancer Institute	Orlando	Florida	32806	Active, not recruiting
UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	33324	Recruiting
Emory Proton Therapy Center	Atlanta	Georgia	30308	Active, not recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Active, not recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Active, not recruiting
Emory Saint Joseph's Hospital	Atlanta	Georgia	30342	Active, not recruiting
Alton Memorial Hospital	Alton	Illinois	62002	Recruiting
Northwestern Medicine Cancer Center Kishwaukee	DeKalb	Illinois	60115	Recruiting
Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	60134	Recruiting
Memorial Hospital East	Shiloh	Illinois	62269	Recruiting
Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	60555	Recruiting
Maryland Proton Treatment Center	Baltimore	Maryland	21201	Recruiting
University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	21201	Recruiting
UM Upper Chesapeake Medical Center	Bel Air	Maryland	21014	Active, not recruiting
Massachusetts General Hospital Cancer Center	Boston	Massachusetts	02114	Recruiting
McLaren Cancer Institute-Bay City	Bay City	Michigan	48706	Recruiting
Corewell Health Dearborn Hospital	Dearborn	Michigan	48124	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Recruiting
McLaren Cancer Institute-Flint	Flint	Michigan	48532	Recruiting
Karmanos Cancer Institute at McLaren Greater Lansing	Lansing	Michigan	48910	Recruiting
McLaren Cancer Institute-Lapeer Region	Lapeer	Michigan	48446	Recruiting
McLaren Cancer Institute-Owosso	Owosso	Michigan	48867	Recruiting
Corewell Health William Beaumont University Hospital	Royal Oak	Michigan	48073	Recruiting
Corewell Health Beaumont Troy Hospital	Troy	Michigan	48085	Recruiting
Mayo Clinic Health System in Albert Lea	Albert Lea	Minnesota	56007	Completed
Mercy Hospital	Coon Rapids	Minnesota	55433	Recruiting
Unity Hospital	Fridley	Minnesota	55432	Active, not recruiting
Mayo Clinic Health Systems-Mankato	Mankato	Minnesota	56001	Completed
Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	55109	Recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Recruiting
Mayo Clinic Radiation Therapy-Northfield	Northfield	Minnesota	55057	Active, not recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Active, not recruiting
Ridgeview Medical Center	Waconia	Minnesota	55387	Recruiting
Siteman Cancer Center at Saint Peters Hospital	City of Saint Peters	Missouri	63376	Recruiting
Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	63141	Recruiting
Mercy Hospital Springfield	Springfield	Missouri	65804	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Mercy Hospital South	St Louis	Missouri	63128	Recruiting
Siteman Cancer Center-South County	St Louis	Missouri	63129	Recruiting
Siteman Cancer Center at Christian Hospital	St Louis	Missouri	63136	Recruiting
Mercy Hospital Saint Louis	St Louis	Missouri	63141	Recruiting
Memorial Sloan Kettering Basking Ridge	Basking Ridge	New Jersey	07920	Recruiting
Memorial Sloan Kettering Monmouth	Middletown	New Jersey	07748	Recruiting
Memorial Sloan Kettering Bergen	Montvale	New Jersey	07645	Recruiting
Memorial Sloan Kettering Commack	Commack	New York	11725	Recruiting
Memorial Sloan Kettering Westchester	East White Plains	New York	10604	Recruiting
New York Proton Center	New York	New York	10035	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Memorial Sloan Kettering Nassau	Uniondale	New York	11553	Recruiting
UH Seidman Cancer Center at UH Avon Health Center	Avon	Ohio	44011	Recruiting
UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	44122	Recruiting
Geauga Hospital	Chardon	Ohio	44024	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Case Western Reserve University	Cleveland	Ohio	44106	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
Mercy Cancer Center-Elyria	Elyria	Ohio	44035	Suspended
UH Seidman Cancer Center at Landerbrook Health Center	Mayfield Heights	Ohio	44124	Suspended
UH Seidman Cancer Center at Lake Health Mentor Campus	Mentor	Ohio	44060	Recruiting
UH Seidman Cancer Center at Southwest General Hospital	Middleburg Heights	Ohio	44130	Recruiting
University Hospitals Parma Medical Center	Parma	Ohio	44129	Recruiting
University Hospitals Portage Medical Center	Ravenna	Ohio	44266	Recruiting
UH Seidman Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	44870	Recruiting
University Hospitals Sharon Health Center	Wadsworth	Ohio	44281	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	44145	Suspended
UHHS-Westlake Medical Center	Westlake	Ohio	44145	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	19104	Recruiting
Covenant Health Proton Center	Knoxville	Tennessee	37909	Recruiting
Covenant Health Cancer Centers	Knoxville	Tennessee	37916	Recruiting
Covenant Health Cancer Centers - West	Knoxville	Tennessee	37932	Recruiting
Covenant Health Oncology Group - Maryville	Maryville	Tennessee	37804	Suspended
Covenant Health Oncology Group - Oak Ridge	Oak Ridge	Tennessee	37830	Recruiting
MD Anderson in The Woodlands	Conroe	Texas	77384	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
MD Anderson West Houston	Houston	Texas	77079	Recruiting
MD Anderson League City	League City	Texas	77573	Recruiting
MD Anderson in Sugar Land	Sugar Land	Texas	77478	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
Inova Alexandria Hospital	Alexandria	Virginia	22304	Active, not recruiting
Inova Schar Cancer Institute	Fairfax	Virginia	22031	Active, not recruiting
Inova Fair Oaks Hospital	Fairfax	Virginia	22033	Active, not recruiting
Inova Loudoun Hospital	Leesburg	Virginia	20176	Active, not recruiting
University of Washington Medical Center - Montlake	Seattle	Washington	98195	Active, not recruiting
Mayo Clinic Health System-Eau Claire Clinic	Eau Claire	Wisconsin	54701	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT03801876, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 10, 2026

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The complete protocol, eligibility criteria, and contact information for NCT03801876 live on ClinicalTrials.gov.

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