ClinicalTrials.gov record
A Study of Salvage Radiotherapy With or Without Enzalutamide in Recurrent Prostate Cancer Following Surgery
ClinicalTrials.gov ID: NCT03809000
Public ClinicalTrials.gov record NCT03809000. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
STEEL: A Randomized Phase II Trial of Salvage Radiotherapy With Standard vs Enhanced Androgen Deprivation Therapy (With Enzalutamide) in Patients With Post-Prostatectomy PSA Recurrences With Aggressive Disease Features
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Patients with post-prostatectomy PSA (Prostate Specific Antigen) recurrences with aggressive disease features will receive salvage radiation therapy and standard androgen deprivation therapy (ADT) or enhanced ADT to determine if there is any improvement in progression-free survival when enhanced ADT is used compared to standard ADT.
Study identification
- NCT ID
- NCT03809000
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 188 participants
Conditions and interventions
Conditions
Interventions
- Radiation Therapy Radiation
- Enzalutamide Drug
- Bicalutamide Drug
- GnRH analog Drug
Radiation · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 14, 2019
- Primary completion
- Apr 6, 2023
- Completion
- Sep 14, 2029
- Last update posted
- Dec 29, 2025
2019 – 2029
United States locations
- U.S. sites
- 106
- U.S. states
- 22
- U.S. cities
- 92
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Center for Cancer Care - Gilbert | Gilbert | Arizona | 85297 | — |
| Arizona Center for Cancer Care - Peoria | Peoria | Arizona | 85381 | — |
| Arizona Center for Cancer Care - Phoenix | Phoenix | Arizona | 85027 | — |
| Arizona Center for Cancer Care - Scottsdale East | Scottsdale | Arizona | 85251 | — |
| Arizona Center for Cancer Care - Scottsdale North | Scottsdale | Arizona | 85258 | — |
| Arizona Center for Cancer Care - Surprise | Surprise | Arizona | 85374 | — |
| Marin Cancer Care, Inc. | Greenbrae | California | 94904 | — |
| Marin Health Medical Center | Greenbrae | California | 94904 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| USC Medical Center - Los Angeles County | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Roseville Radiation Oncology Center | Roseville | California | 95661 | — |
| Sutter Roseville Medical Center | Roseville | California | 95661 | — |
| Sutter Medical Center Sacramento | Sacramento | California | 95816 | — |
| University of California, San Francisco | San Francisco | California | 94158 | — |
| Valley View Hospital Cancer Center | Glenwood Springs | Colorado | 81601 | — |
| University of Florida Health Science Center | Gainesville | Florida | 32608 | — |
| AdventHealth Orlando | Orlando | Florida | 32804 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Nancy N. & J.C. Lewis Cancer & Research Pavilion | Savannah | Georgia | 31405 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| Kansas University Cancer Center Overland Park | Overland Park | Kansas | 66210 | — |
| Kansas University Cancer Center Westwood | Westwood | Kansas | 66205 | — |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | — |
| LSU Healthcare Network/Metairie Multi-Specialty Clinic | Metairie | Louisiana | 70006 | — |
| Coastal Cancer Treatment Center - Bath | Bath | Maine | 04530 | — |
| Waldo Count General Hospital - Belfast | Belfast | Maine | 04915 | — |
| Maine Health/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford | Maine | 04005 | — |
| Maine Health/Stephens Memorial - Norway | Norway | Maine | 04268 | — |
| Maine Medical Center - Bramhall S Portland | Portland | Maine | 04102 | — |
| Penobscot Bay Medical Center - Rockport | Rockport | Maine | 04856 | — |
| Maine Health CC of York County - Sanford | Sanford | Maine | 04073 | — |
| Maine Health/SMHCancer Care and Blood Disorders - Sanford | Sanford | Maine | 04073 | — |
| Maine Medical Cancer Center - Scarborough Campus | Scarborough | Maine | 04074 | — |
| Maine Medical Partners - South Portland | South Portland | Maine | 04106 | — |
| McLaren Cancer Institute - Bloomfield | Bloomfield | Michigan | 48302 | — |
| 21st Century Oncology MHP - Clarkston | Clarkston | Michigan | 48346 | — |
| McLaren Cancer Institute - Clarkston | Clarkston | Michigan | 48346 | — |
| William Beaumont Hospital - Dearborn | Dearborn | Michigan | 48124 | — |
| Wayne State/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| 21st Century Oncology MHP - Farmington | Farmington Hills | Michigan | 48334 | — |
| McLaren Cancer Institute - Flint | Flint | Michigan | 48532 | — |
| Singh and Arora Hematology Oncology PC | Flint | Michigan | 48532 | — |
| McLaren Cancer Institute - Greater Lansing | Lansing | Michigan | 48910 | — |
| Mid-Michigan Physicians - Lansing | Lansing | Michigan | 48912 | — |
| McLaren Cancer Institute - Lapeer Region | Lapeer | Michigan | 48446 | — |
| 21st Century Oncology MHP - Macomb | Macomb | Michigan | 48044 | — |
| 21st Century Oncology MHP - Madison Heights | Madison Heights | Michigan | 48071 | — |
| McLaren Cancer Institute - Macomb | Mount Clemens | Michigan | 48043 | — |
| McLaren Cancer Institute - Central Michigan | Mount Pleasant | Michigan | 48858 | — |
| McLaren Cancer Institute - Owosso | Owosso | Michigan | 48867 | — |
| McLaren Cancer Institute - Northern Michigan | Petoskey | Michigan | 49770 | — |
| McLaren Cancer Institute - Port Huron | Port Huron | Michigan | 48060 | — |
| William Beaumont Hospital - Royal Oak | Royal Oak | Michigan | 48073 | — |
| William Beaumont Hospital - Troy | Sterling Heights | Michigan | 48314 | — |
| 21st Century Oncology MHP - Troy | Troy | Michigan | 48098 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Minnesota Oncology Hematology PA - Maplewood | Maplewood | Minnesota | 55109 | — |
| Coborn Cancer Center | Saint Cloud | Minnesota | 56303 | — |
| HealthPartners, Inc. | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Kansas University Cancer Center North | Kansas City | Missouri | 64154 | — |
| Kansas University Cancer Center Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Exeter Hospital | Exeter | New Hampshire | 03833 | — |
| Dartmouth Hitchcock Medical Center/Norris Cotton Cancer Center | Lebanon | New Hampshire | 03756 | — |
| University Physicians at Oneida | Oneida | New York | 13421 | — |
| Upstate Cancer Center Radiation Oncology at Oneida | Oneida | New York | 13421 | — |
| University Physicians at Oswego | Oswego | New York | 13126 | — |
| Upstate Cancer Radiation Oncology at Oswego | Oswego | New York | 13126 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Upstate Cancer Center at Hill Radiation Oncology | Syracuse | New York | 13210 | — |
| UNC Rex Cancer Center | Raleigh | North Carolina | 27607 | — |
| Rex Cancer Center of Wakefield | Raleigh | North Carolina | 27614 | — |
| WellSpan Health - Ephrata Cancer Center | Ephrata | Pennsylvania | 17522 | — |
| WellSpan Health - Adams Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| WellSpan Health - Sechler Family Cancer Center | Lebanon | Pennsylvania | 17402 | — |
| University of Pittsburgh Medical Center - Shadyside Hospital | Pittsburgh | Pennsylvania | 15232 | — |
| WellSpan Health - York Hospital | York | Pennsylvania | 17403 | — |
| Gibbs Cancer Center - Pelham | Greer | South Carolina | 29650 | — |
| Spartanburg Medical Center | Spartanburg | South Carolina | 29303 | — |
| UT Southwestern/Simmons Cancer Center - Dallas | Dallas | Texas | 75390 | — |
| American Fork Hospital | American Fork | Utah | 84003 | — |
| Cedar City Hospital | Cedar City | Utah | 84721 | — |
| Logan Regional Medical Center | Logan | Utah | 84341 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Utah Valley Regional Medical Center | Provo | Utah | 84604 | — |
| Dixie Regional Medical Center | St. George | Utah | 84790 | — |
| Dartmouth Hitchcock Medical Center/Norris Cancer Ctr. - St. Johnsbury | Saint Johnsbury | Vermont | 05819 | — |
| Sentara Cancer Institute at Sentara CarePlex Hospital | Hampton | Virginia | 23666 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| Sentara Virginia Beach General Hospital | Virginia Beach | Virginia | 23454 | — |
| Aspirus Langlade Hospital | Antigo | Wisconsin | 54409 | — |
| University Cancer Center Johnson Creek | Johnson Creek | Wisconsin | 53038 | — |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | — |
| Froedtert Menomonee Falls Hospital | Menomonee Falls | Wisconsin | 53051 | — |
| Froedtert Hospital & the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Drexel Town Square | Oak Creek | Wisconsin | 53154 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Froedtert West Bend Hospital | West Bend | Wisconsin | 53095 | — |
| Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids | Wisconsin | 54494 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03809000, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 29, 2025 · Synced Sep 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03809000 live on ClinicalTrials.gov.