GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)
Public ClinicalTrials.gov record NCT03815825. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx, an Antisense Inhibitor of Complement Factor B, in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Evaluate the effect of IONIS-FB-LRx on the rate of change of the area of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) measured by fundus autofluorescence (FAF).
Study identification
- NCT ID
- NCT03815825
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 332 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 4, 2019 (Actual)
- Primary completion
- Apr 18, 2024 (Actual)
- Completion
- Jun 12, 2024 (Actual)
- Last update posted
- Mar 7, 2025
2019 – 2024
United States locations
- U.S. sites
- 55
- U.S. states
- 20
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| IONIS Investigative Site | Phoenix | Arizona | 85020 | — |
| IONIS Investigative Site | Phoenix | Arizona | 85021 | — |
| IONIS Investigative Site | Phoenix | Arizona | 85053 | — |
| IONIS Investigative Site | Sun City | Arizona | 85351 | — |
| IONIS Investigative Site | Beverly Hills | California | 90211 | — |
| IONIS Investigative Site | Huntington Beach | California | 92697 | — |
| IONIS Investigative Site | La Jolla | California | 92093 | — |
| IONIS Investigative Site | Long Beach | California | 90807 | — |
| IONIS Investigative Site | Poway | California | 92064 | — |
| IONIS Investigative Site | San Francisco | California | 94109 | — |
| IONIS Investigative Site | Colorado Springs | Colorado | 80909 | — |
| IONIS Investigative Site | Clearwater | Florida | 33761 | — |
| IONIS Investigative Site | Fort Myers | Florida | 33907 | — |
| IONIS Investigative Site | Lake Worth | Florida | 33461 | — |
| IONIS Investigative Site | Lakeland | Florida | 33801 | — |
| IONIS Investigative Site | Melbourne | Florida | 32901 | — |
| IONIS Investigative Site | Stuart | Florida | 34994 | — |
| IONIS Investigative Site | Tampa | Florida | 33612 | — |
| IONIS Investigative Site | Winter Haven | Florida | 33880 | — |
| IONIS Investigative Site | Augusta | Georgia | 30909 | — |
| IONIS Investigative Site | Lemont | Illinois | 60439 | — |
| IONIS Investigative Site | Springfield | Illinois | 62702 | — |
| IONIS Investigative Site | Leawood | Kansas | 66211 | — |
| IONIS Investigative Site | Baltimore | Maryland | 21204 | — |
| IONIS Investigative Site | Baltimore | Maryland | 21209 | — |
| IONIS Investigative Site | Hagerstown | Maryland | 21740 | — |
| IONIS Investigative Site | Southaven | Mississippi | 38671 | — |
| IONIS Investigative Site | Albuquerque | New Mexico | 87109 | — |
| IONIS Investigative Site | Asheville | North Carolina | 28803 | — |
| IONIS Investigative Site | Hickory | North Carolina | 28602 | — |
| IONIS Investigative Site | Winston-Salem | North Carolina | 27157 | — |
| IONIS Investigative Site | Cleveland | Ohio | 44106 | — |
| IONIS Investigative Site | Cleveland | Ohio | 44130 | — |
| IONIS Investigative Site | Cleveland | Ohio | 44195 | — |
| IONIS Investigative Site | Tulsa | Oklahoma | 74114 | — |
| IONIS Investigative Site | Philadelphia | Pennsylvania | 19104 | — |
| IONIS Investigative Site | Pittsburgh | Pennsylvania | 15213 | — |
| IONIS Investigative Site | West Mifflin | Pennsylvania | 15122 | — |
| IONIS Investigative Site | Greenville | South Carolina | 29605 | — |
| IONIS Investigative Site | Ladson | South Carolina | 29456 | — |
| IONIS Investigative Site | Nashville | Tennessee | 37203 | — |
| IONIS Investigative Site | Abilene | Texas | 79606 | — |
| IONIS Investigative Site | Arlington | Texas | 76012 | — |
| IONIS Investigative Site | Austin | Texas | 78705 | — |
| IONIS Investigative Site | Bellaire | Texas | 77401 | — |
| IONIS Investigative Site | Dallas | Texas | 75231 | — |
| IONIS Investigative Site | McAllen | Texas | 78503 | — |
| IONIS Investigative Site | San Antonio | Texas | 78240 | — |
| IONIS Investigative Site | Southlake | Texas | 76051 | — |
| IONIS Investigative Site | The Woodlands | Texas | 77384 | — |
| IONIS Investigative Site | Willow Park | Texas | 76087 | — |
| IONIS Investigative Site | Salt Lake City | Utah | 84107 | — |
| IONIS Investigative Site | Lynchburg | Virginia | 24502 | — |
| IONIS Investigative Site | Richmond | Virginia | 23235 | — |
| IONIS Investigative Site | Silverdale | Washington | 98383 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03815825, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 7, 2025 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03815825 live on ClinicalTrials.gov.