Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine
Public ClinicalTrials.gov record NCT03832998. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Efficacy and Safety of Erenumab in Children (6 to < 12 Years) and Adolescents (12 to < 18 Years) With Chronic Migraine (OASIS PEDIATRIC [CM])
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the efficacy and safety of erenumab in migraine prevention in children (6 to \<12 years) and adolescents (12 to \<18 years) with chronic migraine. The study hypothesis is that in pediatric participants with chronic migraine, the combined erenumab dose group has a greater reduction from baseline to week 9 through week 12 (month 3) in monthly migraine days (MMDs) when compared with placebo in the double-blind treatment phase (DBTP).
Study identification
- NCT ID
- NCT03832998
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 284 participants
Conditions and interventions
Conditions
Interventions
- Erenumab Dose 1 Drug
- Erenumab Dose 2 Drug
- Erenumab Dose 3 Drug
- Placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 6 Years to 17 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 5, 2019 (Actual)
- Primary completion
- Jan 8, 2025 (Actual)
- Completion
- Jan 7, 2026 (Actual)
- Last update posted
- Jan 20, 2026
2019 – 2026
United States locations
- U.S. sites
- 38
- U.S. states
- 23
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Paradigm Clinical Research Center Inc | San Diego | California | 92108 | — |
| Childrens Hospital Colorado | Aurora | Colorado | 80045 | — |
| Colorado Springs Neurological Associates | Colorado Springs | Colorado | 80907 | — |
| New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Childrens National Health System | Washington D.C. | District of Columbia | 20010 | — |
| TrueBlue Clinical Research | Brandon | Florida | 33511 | — |
| Northwest Florida Clinical Research Group Limited Liability Company | Gulf Breeze | Florida | 32561 | — |
| Nicklaus Childrens Hospital | Miami | Florida | 33155 | — |
| Pediatric Epilepsy and Neurology Specialists | Tampa | Florida | 33609 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Rare Disease Research Center Pediatrics | Atlanta | Georgia | 30329 | — |
| CenExel iResearch, LLC | Savannah | Georgia | 31405 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Chicago Headache Center and Research Institute | Chicago | Illinois | 60657 | — |
| Josephson Wallack Munshower Neurology | Indianapolis | Indiana | 46256 | — |
| University of Maryland, Baltimore | Baltimore | Maryland | 21201 | — |
| New England Regional Headache Center Inc | Worcester | Massachusetts | 14226 | — |
| Michigan Head Pain and Neurological Institute | Ann Arbor | Michigan | 48104 | — |
| Clinical Research Institute Inc | Plymouth | Minnesota | 55441 | — |
| Childrens Mercy Hospital and Clinics | Kansas City | Missouri | 64108 | — |
| Mercy Research | St Louis | Missouri | 63141 | — |
| Meridian Clinical Research LLC | Hastings | Nebraska | 68901 | — |
| Dent Neurosciences Research Center | Amherst | New York | 14226 | — |
| Modern Migraine MD | New York | New York | 10001 | — |
| Columbia University Irving Medical Center | New York | New York | 10032 | — |
| Cincinnati Childrens Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Nationwide Childrens Hospital | Columbus | Ohio | 43205 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Childrens Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Preferred Primary Care Physicians, Inc | Pittsburgh | Pennsylvania | 15236 | — |
| Palmetto Gastroenterology Clinical Research, LLC | Summerville | South Carolina | 29486 | — |
| Child Neurology Consultants of Austin | Austin | Texas | 78757 | — |
| Helios Clinical Research Inc | Burleson | Texas | 76028 | — |
| Stryde Consulting LLC | Frisco | Texas | 75033 | — |
| Childrens Specialty Group | Norfolk | Virginia | 23507 | — |
| Vaught Neurological Services | Crab Orchard | West Virginia | 25827 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03832998, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 20, 2026 · Synced Oct 24, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03832998 live on ClinicalTrials.gov.