Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy
Public ClinicalTrials.gov record NCT03860935. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of AG10 in Subjects With Symptomatic Transthyretin Amyloid Cardiomyopathy (ATTRibute-CM Trial)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Phase 3 efficacy and safety study to evaluate acoramidis (AG10) HCl 800 mg administered orally twice a day compared to placebo in subjects with symptomatic Transthyretin Amyloid Cardiomyopathy (ATTR-CM).
Study identification
- NCT ID
- NCT03860935
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 632 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 19, 2019 (Actual)
- Primary completion
- May 11, 2023 (Actual)
- Completion
- May 11, 2023 (Actual)
- Last update posted
- Jun 27, 2024
2019 – 2023
United States locations
- U.S. sites
- 40
- U.S. states
- 23
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Pacific Heart Institute | Santa Monica | California | 90404 | — |
| University of Colorado Hospital - Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| Yale School of Medicine | New Haven | Connecticut | 06473 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| University of Miami - Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| Piedmont Heart Institute Athens | Athens | Georgia | 30606 | — |
| Emory Heart and Vascular Center | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| MedStar Medical Group Cardiology at Franklin Square Medical Center | Baltimore | Maryland | 21218 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Saint Elizabeth's Medical Center | Boston | Massachusetts | 02135 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Saint Luke's Hospital - Kansas City | Kansas City | Missouri | 64111 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| North Shore University Hospital | Manhasset | New York | 11030 | — |
| New York University Langone Health | New York | New York | 10010 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10034 | — |
| Laurelton Heart Specialist | Rosedale | New York | 11422 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| University of North Carolina - Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Duke University Health System | Durham | North Carolina | 27710 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213 | — |
| The Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health - Greenville Memorial Hospital | Greenville | South Carolina | 29605 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Virginia Commonwealth University Medical Center | Richmond | Virginia | 23298 | — |
| Carilion Clinic Roanoke Heart Institute | Roanoke | Virginia | 24014 | — |
| University of Washington School of Medicine | Seattle | Washington | 98195 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03860935, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 27, 2024 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03860935 live on ClinicalTrials.gov.