ClinicalTrials.gov record
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
ClinicalTrials.gov ID: NCT03872401
Public ClinicalTrials.gov record NCT03872401. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.
Study identification
- NCT ID
- NCT03872401
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 12,301 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 10, 2019
- Primary completion
- Jul 24, 2025
- Completion
- Jul 24, 2025
- Last update posted
- Jun 24, 2026
2019 – 2025
United States locations
- U.S. sites
- 145
- U.S. states
- 40
- U.S. cities
- 130
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Research Center LLC | Athens | Alabama | 35611 | — |
| Cardiovascular Associates | Birmingham | Alabama | 35243 | — |
| Heart Center Research LLC | Huntsville | Alabama | 35801 | — |
| Mobile Heart Specialists PC | Mobile | Alabama | 36608 | — |
| Arkansas Cardiology | Little Rock | Arkansas | 72205 | — |
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| Cardiovascular Research Foundation of Southern California | Beverly Hills | California | 90210 | — |
| Westside Medical Associates of Los Angeles | Beverly Hills | California | 90211 | — |
| West Coast Research LLC | Dublin | California | 94568 | — |
| Desert Oasis Healthcare Medical Group | Palm Springs | California | 92262 | — |
| Covigilant Research, LLC | Riverside | California | 92506 | — |
| Sierra Clinical Research | Roseville | California | 95661 | — |
| Center for Clinical Trials of Sacramento Inc | Sacramento | California | 95823 | — |
| Harbor University of California Los Angeles Medical Center | Torrance | California | 90502 | — |
| Optumcare Colorado Springs LLC | Colorado Springs | Colorado | 80906 | — |
| University of Colorado Memorial Health System | Colorado Springs | Colorado | 80909 | — |
| New West Physicians | Golden | Colorado | 80401 | — |
| South Denver Cardiology Associates | Littleton | Colorado | 80120 | — |
| Cardiology Associates of Fairfield County, PC | Stamford | Connecticut | 06905 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Bay Area Cardiology | Brandon | Florida | 33511 | — |
| Nature Coast Clinical Research LLC | Crystal River | Florida | 34429 | — |
| Daytona Heart Group | Daytona Beach | Florida | 32114 | — |
| Cardiology Research Associates | Daytona Beach | Florida | 32117 | — |
| Complete Health Research | DeLand | Florida | 32720 | — |
| Cohen Medical Associates PA | Delray Beach | Florida | 33446 | — |
| Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care | Fort Lauderdale | Florida | 33312 | — |
| George E Platt MD | Green Cove Springs | Florida | 32043 | — |
| Research Physicians Network Alliance | Hollywood | Florida | 33021 | — |
| University of Florida and Shands Hospital | Jacksonville | Florida | 32209 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| First Coast Cardiovascular Institute PA | Jacksonville | Florida | 32256 | — |
| Baptist Health Research Institute | Jacksonville Beach | Florida | 32250 | — |
| Gad Research Center | Miami | Florida | 33155 | — |
| Cardiovascular Research Center of South Florida | Miami | Florida | 33173 | — |
| Ocala Research Institute, Inc | Ocala | Florida | 34471 | — |
| Cardiology Consultants | Pensacola | Florida | 32501 | — |
| Charlotte Heart Group Research Center | Port Charlotte | Florida | 33952 | — |
| Intercoastal Medical Group | Sarasota | Florida | 34232 | — |
| Cardiovascular Center of Sarasota | Sarasota | Florida | 34239 | — |
| Florida Cardiology Group | Winter Park | Florida | 32792 | — |
| The Florida Lipid Institute | Winter Park | Florida | 32792 | — |
| NSC Research | Johns Creek | Georgia | 30024 | — |
| Kootenai Heart Clinics, LLC | Coeur d'Alene | Idaho | 83814 | — |
| Northwest Heart Clinical Research LLC | Arlington Heights | Illinois | 60005 | — |
| Deaconess Clinic | Evansville | Indiana | 47713 | — |
| LaPorte County Institute for Clinical Research | Michigan City | Indiana | 46360 | — |
| Midwest Cardiovascular Research Foundation | Davenport | Iowa | 52801 | — |
| The University of Iowa College of Public Health | Iowa City | Iowa | 52242 | — |
| MercyOne Iowa Heart Center | West Des Moines | Iowa | 50266 | — |
| The University of Kansas Medical Center | Kansas City | Kansas | 66160-7601 | — |
| Saint Elizabeth Covington | Covington | Kentucky | 41011 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| Alexandria Cardiology Clinic | Alexandria | Louisiana | 71301 | — |
| Grace Research LLC | Bossier City | Louisiana | 71111 | — |
| Horizon Research Group of Opelousas LLC | Eunice | Louisiana | 70535 | — |
| Louisiana Heart Center | Hammond | Louisiana | 70403 | — |
| Barnum Medical Research | Natchitoches | Louisiana | 71457 | — |
| Grace Research LLC | Shreveport | Louisiana | 71105 | — |
| Louisiana Heart Center | Slidell | Louisiana | 70458 | — |
| Northern Light Eastern Maine Medical Center | Bangor | Maine | 04401 | — |
| Southern Maine Health Care | Biddeford | Maine | 04005 | — |
| Maryland Cardiovascular Specialists | Baltimore | Maryland | 21229 | — |
| Metropolitan Cardiovascular Consultants LLC | Beltsville | Maryland | 20705 | — |
| TidalHealth Peninsula Regional, Inc | Salisbury | Maryland | 21804 | — |
| Brigham and Womens Hospital | Boston | Massachusetts | 02215 | — |
| Charles River Medical Associates | Framingham | Massachusetts | 01701 | — |
| East Mountain Medical Associates, PC | Great Barrington | Massachusetts | 01230 | — |
| Baystate Health Center | Springfield | Massachusetts | 01199 | — |
| Ahmed Arif Medical Research Center LLC | Flint | Michigan | 48504 | — |
| Healthy Heart Cardiology | Grand Rapids | Michigan | 49546 | — |
| Rajendra H Mehta, MD, PC | Jackson | Michigan | 49201 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| Saint Marys Medical Center | Duluth | Minnesota | 55805 | — |
| Minneapolis Heart Institute Foundation | Minneapolis | Minnesota | 55407 | — |
| Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| HealthEast Medical Research Institute | Saint Paul | Minnesota | 55102 | — |
| Kansas City Veterans Affairs Medical Center | Kansas City | Missouri | 64128 | — |
| Mercy Research | St Louis | Missouri | 63141 | — |
| Great Falls Clinic LLP | Great Falls | Montana | 59405 | — |
| Bryan Heart | Lincoln | Nebraska | 68506 | — |
| Nebraska Western Iowa Health Care System | Omaha | Nebraska | 68105 | — |
| Palm Research Center Inc | Las Vegas | Nevada | 89128 | — |
| Virtua Health, Inc. | Voorhees Township | New Jersey | 08043 | — |
| Healthwise Medical Associates | Brooklyn | New York | 11206 | — |
| Trinity Medical Western New York, PC | Cheektowaga | New York | 14227 | — |
| WMCHealth Heart and Vascular Institute Kingston Division of Cardiology | Kingston | New York | 12401 | — |
| Northwell Health Physician Partners Cardiology | Manhasset | New York | 11030 | — |
| North Shore Diabetes and Endocrine Associates | New Hyde Park | New York | 11042 | — |
| Northwell Health Lenox Hill Heart and Vascular | New York | New York | 10022 | — |
| Hudson Valley Cardiovascular Physicians PC | Poughkeepsie | New York | 12601 | — |
| Saratoga Clinical Research, LLC | Saratoga Springs | New York | 12866 | — |
| Division of Cardiovascular Research at Peconic Bay Medical Center | Southampton | New York | 11968 | — |
| Asheville Cardiology Associates | Asheville | North Carolina | 28803 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Novant Health Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Moses H Cone Memorial Hospital | Greensboro | North Carolina | 27401 | — |
| Crossroads Clinical Research Inc | Mooresville | North Carolina | 28117 | — |
| Piedmont Medical Group Research of Rocky Mount | Rocky Mount | North Carolina | 27804 | — |
| PMG Research of Salisbury | Salisbury | North Carolina | 28144 | — |
| Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| North Ohio Heart Center | Elyria | Ohio | 44035 | — |
| Sanjay Vora Research LLC | Marion | Ohio | 43302 | — |
| North Ohio Heart Center-Sandusky | Sandusky | Ohio | 44870 | — |
| Heart House Research Foundation | Springfield | Ohio | 45504 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74133 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Capital Area Research LLC | Camp Hill | Pennsylvania | 17011 | — |
| Geisinger Holy Spirit | Camp Hill | Pennsylvania | 17011 | — |
| Doylestown Health Cardiology | Doylestown | Pennsylvania | 18901 | — |
| Lycoming Internal Medicine Inc | Jersey Shore | Pennsylvania | 17740 | — |
| Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Cardiology Consultants of Philadelphia CCP | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | — |
| Miriam Hospital | Providence | Rhode Island | 02906 | — |
| Pharmacorp Clinical Trials Inc | Charleston | South Carolina | 29412 | — |
| Piedmont Research Partners | Fort Mill | South Carolina | 29707 | — |
| Tribe Clinical Research LLC DBA Mountain View Clinical Research | Greenville | South Carolina | 29607 | — |
| Main Street Physicians Care Waterway | Little River | South Carolina | 29566 | — |
| The Diabetes Center | Murrells Inlet | South Carolina | 29576 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Parkway Cardiology Associates | Oak Ridge | Tennessee | 37830 | — |
| Soltero Cardiovascular Research Center | Dallas | Texas | 75226 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| Humble Cardiology Associates | Kingwood | Texas | 77339 | — |
| Texas Cardiology Associates of Houston | Kingwood | Texas | 77339 | — |
| Texas Institute for Kidney and Endocrine Disorders | Lufkin | Texas | 75904 | — |
| Texas Institute of Cardiology | McKinney | Texas | 75071 | — |
| Southern Endocrinology Associates PA | Mesquite | Texas | 75149 | — |
| Permian Research Foundation | Odessa | Texas | 79761 | — |
| South Texas Cardiovascular Consultants PLLC | San Antonio | Texas | 78201 | — |
| Mercury Medical Conversions LTD | San Antonio | Texas | 78229 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Alpine Research Organization | Farmington | Utah | 84025 | — |
| Suffolk Multispecialty Research LLC | Suffolk | Virginia | 23435 | — |
| Selma Medical Associates | Winchester | Virginia | 22601 | — |
| Multicare Institute for Research and Innovation | Puyallup | Washington | 98372 | — |
| Universal Research Group LLC | Tacoma | Washington | 98405 | — |
| Aspirus Research Institute | Wausau | Wisconsin | 54401 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 707 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03872401, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 24, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03872401 live on ClinicalTrials.gov.