RaPiDS- A Phase 2 Study of Anti-PD-1 Independently or in Combination With Anti-CTLA-4 in Second-Line Cervical Cancer
Public ClinicalTrials.gov record NCT03894215. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Two-arm, Randomized, Non-comparative, Phase 2 Trial of AGEN2034 (Anti-PD-1) as a Monotherapy or Combination Therapy With AGEN1884 (Anti- CTLA4) or With Placebo in Women With Recurrent Cervical Cancer (Second Line) - RaPiDS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a randomized, blinded, non-comparative, two-arm Phase 2 clinical trial to assess the efficacy and safety of AGEN2034 administered with placebo (Treatment Arm 1 - monotherapy) or with AGEN1884 (Treatment Arm 2- combination therapy) for treatment of patients with advanced cervical cancer who relapsed or progressed after receiving first-line platinum-based chemotherapy. The study is not intended to compare the efficacy of the 2 experimental arms. Rather, the efficacy of each arm will be evaluated against its relevant historical controls as appropriate.
Study identification
- NCT ID
- NCT03894215
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 211 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 1, 2019 (Actual)
- Primary completion
- Mar 26, 2025 (Actual)
- Completion
- Mar 26, 2025 (Actual)
- Last update posted
- Mar 27, 2026
2019 – 2025
United States locations
- U.S. sites
- 42
- U.S. states
- 18
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham School of Medicine | Birmingham | Alabama | 35233-1802 | — |
| University of South Alabama Mitchell Cancer Institute | Mobile | Alabama | 36604 | — |
| Arizona Oncology - Biltmore Cancer Center | Phoenix | Arizona | 85016 | — |
| Arizona Oncology - Tucson - Wilmot Road Location | Tucson | Arizona | 85711 | — |
| University of California, San Diego (UCSD) - Moores Cancer Center | La Jolla | California | 92093 | — |
| UCLA- Women's Health Clinical Research Unit (WHCRU) | Los Angeles | California | 90095 | — |
| Gynecologic Oncology Associates | Newport | California | 92663 | — |
| California Pacific Medical Center | San Francisco | California | 94115-1821 | — |
| University of California, San Francisco Medical Center | San Francisco | California | 94158 | — |
| Baptist MD Anderson Cancer Center | Jacksonville | Florida | 32207 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Northside Hospital | Atlanta | Georgia | 30342 | — |
| St Joseph's Hospital | Savannah | Georgia | 31405-6015 | — |
| Community Health Network - North Cancer Center | Indianapolis | Indiana | 46250 | — |
| University of Kentucky Albert B. Chandler Hospital | Lexington | Kentucky | 40536 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| MD Anderson Cancer Center at Cooper | Camden | New Jersey | 08103 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Northwell Health Monter Cancer Center | Lake Success | New York | 11042 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Albert Einstein College of Medicine | The Bronx | New York | 10461 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| FirstHealth Outpatient Cancer Center | Pinehurst | North Carolina | 28374 | — |
| MetroHealth Medical Center | Cleveland | Ohio | 44109 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Columbus NCORP | Columbus | Ohio | 43215 | — |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104-5418 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| Willamette Valley Cancer Institute | Eugene | Oregon | 97401 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | — |
| Penn Medicine - Jordan Center for Gynecologic Cancer | Philadelphia | Pennsylvania | 19104-5127 | — |
| WellSpan Gynecologic Oncology | York | Pennsylvania | 17403 | — |
| Women & Infants Hospital of Rhode Island | Providence | Rhode Island | 02905 | — |
| Texas Oncology Surgical Specialists - Austin Central | Austin | Texas | 78745 | — |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology - Dallas - Presbyterian Cancer Center | Dallas | Texas | 75231 | — |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Oncology - Fort Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Texas Oncology - San Antonio Medical Center | San Antonio | Texas | 78240 | — |
| Texas Oncology - The Woodlands | The Woodlands | Texas | 77380 | — |
| Texas Oncology | Tyler | Texas | 75702 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03894215, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 27, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03894215 live on ClinicalTrials.gov.