Evaluation of Efficacy, Safety and Tolerability of Aldafermin in a Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study In Subjects With Nonalcoholic Steatohepatitis and Stage 2/3 Fibrosis (ALPINE 2/3)
Public ClinicalTrials.gov record NCT03912532. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-blind, Placebo-controlled, Multi-center Study to Evaluate the Efficacy, Safety, and Tolerability of Three Doses of NGM282 Administered for 24 Weeks for the Treatment of Histologically Confirmed Nonalcoholic Steatohepatitis (NASH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multi-center evaluation of NGM282 in a randomized, double-blind, placebo-controlled study administered for 24 weeks in participants with histologically confirmed NASH and F2/F3 Fibrosis.
Study identification
- NCT ID
- NCT03912532
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 171 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 16, 2019 (Actual)
- Primary completion
- Mar 4, 2021 (Actual)
- Completion
- Mar 29, 2021 (Actual)
- Last update posted
- Jul 3, 2025
2019 – 2021
United States locations
- U.S. sites
- 36
- U.S. states
- 15
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| NGM Clinical Study Site | Chandler | Arizona | 85224 | — |
| NGM Clinical Study Site 814 | Tucson | Arizona | 85712 | — |
| NGM Clinical Study Site 816 | Tucson | Arizona | 85712 | — |
| NGM Clinical Study Site | North Little Rock | Arkansas | 72117 | — |
| NGM Clinical Study Site | Fresno | California | 93720 | — |
| NGM Clinical Study Site | La Jolla | California | 92093 | — |
| NGM Clinical Study Site | Los Angeles | California | 90036 | — |
| NGM Clinical Study Site | Los Angeles | California | 90057 | — |
| NGM Clinical Study Site | Poway | California | 92064 | — |
| NGM Clinical Study Site | Rialto | California | 92377 | — |
| NGM Clinical Study Site | Boca Raton | Florida | 33434 | — |
| NGM Clinical Study Site | Lakewood Rch | Florida | 34211 | — |
| NGM Clinical Study Site | Port Orange | Florida | 32127 | — |
| NGM Clinical Study Site | Sarasota | Florida | 34240 | — |
| NGM Clinical Study Site | The Villages | Florida | 32162 | — |
| NGM Clinical Study Site | Chicago | Illinois | 60611 | — |
| NGM Clinical Study Site | Baton Rouge | Louisiana | 70809 | — |
| NGM Clinical Study Site | Baltimore | Maryland | 21202 | — |
| NGM Clinical Study Site | Ann Arbor | Michigan | 48109 | — |
| NGM Clinical Study Site | Flowood | Mississippi | 39232 | — |
| NGM Clinical Study Site | Jackson | Mississippi | 39216 | — |
| NGM Clinical Study Site | Kansas City | Missouri | 64131 | — |
| NGM Clinical Study Site | St Louis | Missouri | 63104 | — |
| NGM Clinical Study Site | New York | New York | 10029 | — |
| NGM Clinical Study Site | Durham | North Carolina | 27708 | — |
| NGM Clinical Study Site | Fayetteville | North Carolina | 28304 | — |
| NGM Clinical Study Site | Germantown | Tennessee | 38138 | — |
| NGM Clinical Study Site | Hermitage | Tennessee | 37076 | — |
| NGM Clinical Study Site | Austin | Texas | 78757 | — |
| NGM Clinical Study Site 845 | Edinburg | Texas | 78539 | — |
| NGM Clinical Study Site | Edinburg | Texas | 78539 | — |
| NGM Clinical Study Site | Houston | Texas | 77030 | — |
| NGM Clinical Study Site | San Antonio | Texas | 78229 | — |
| NGM Clinical Study Site | San Antonio | Texas | 78233 | — |
| NGM Clinical Study Site | Richmond | Virginia | 23226 | — |
| NGM Clinical Study Site | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03912532, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 3, 2025 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03912532 live on ClinicalTrials.gov.