A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes
Public ClinicalTrials.gov record NCT03914326. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Semaglutide Cardiovascular Outcomes Trial in Patients With Type 2 Diabetes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The researchers are doing this study to look whether the type 2 diabetes medicine, semaglutide, has a positive effect on heart disease. Participants will either get semaglutide tablets or placebo tablets ("dummy" medicine) - which treatment is decided by chance. Participants must take one tablet with water every morning on an empty stomach and not eat or drink anything for at least 30 minutes. The study will last for about 3.5-5 years. Participants will have up to 25 clinic visits and 1 phone call with the study doctor. Women cannot be in the study if pregnant, breast-feeding or if they plan to become pregnant during the study period.
Study identification
- NCT ID
- NCT03914326
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 9,651 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 16, 2019
- Primary completion
- Aug 22, 2024
- Completion
- Aug 22, 2024
- Last update posted
- Dec 10, 2025
2019 – 2024
United States locations
- U.S. sites
- 91
- U.S. states
- 28
- U.S. cities
- 82
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Chambliss Clinical Trials, LLC | Montgomery | Alabama | 36106 | — |
| Medical Investigations, Inc. | Little Rock | Arkansas | 72211 | — |
| Unity Health-Searcy Medical Center | Searcy | Arkansas | 72143 | — |
| B&K Medical Research Center | Fresno | California | 93721-1443 | — |
| University of Vermont Medical Center | Fullerton | California | 92835 | — |
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| Diabetes & Endocrine Associates | La Mesa | California | 91942 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Pacific Clinical Studies | Los Alamitos | California | 90720 | — |
| Facey Medical Foundation | Mission Hills | California | 91345 | — |
| Monterey Endocrine & Diabetes Institute, Inc | Monterey | California | 93940 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| San Diego Family Care | San Diego | California | 92111 | — |
| Lundquist Inst-Biomed Innovtn | Torrance | California | 90502 | — |
| Coastal Metabolic Research Center | Ventura | California | 93003 | — |
| Rocky Mount Reg VA Med-DN | Aurora | Colorado | 80045 | — |
| Creekside Endocrine Associates, PC | Denver | Colorado | 80246 | — |
| New West Physicians,Inc. | Golden | Colorado | 80401 | — |
| East Coast Medical Associates, Inc. | Boca Raton | Florida | 33433 | — |
| Suncoast Clin Res Port Richey | New Port Richey | Florida | 34652 | — |
| AdventHealth Diab Inst | Orlando | Florida | 32804 | — |
| Ellipsis Group | Alpharetta | Georgia | 30022 | — |
| Physicians Research Assoc. LLC | Lawrenceville | Georgia | 30046 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| East West Med Res Inst | Honolulu | Hawaii | 96814 | — |
| Rocky Mountain Diab&Osteo Ctr | Idaho Falls | Idaho | 83404-7596 | — |
| Clinical Invest Special_Gurnee | Gurnee | Illinois | 60031 | — |
| American Health Network of IN LLC_Franklin | Franklin | Indiana | 46131 | — |
| American Health Network of Indiana, LLC_Greenfield | Greenfield | Indiana | 46140 | — |
| Franciscan Health Michigan City | Michigan City | Indiana | 46360 | — |
| American Health Network of IN LLC | Muncie | Indiana | 47304 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| The Research Group of Lexington LLC | Lexington | Kentucky | 40503 | — |
| Robley Rex VA Medical Center | Louisville | Kentucky | 40206 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Tulane University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Ileana J Tandron APMC | Slidell | Louisiana | 70461-4231 | — |
| Northern Pines Hlth Ctr, PC | Buckley | Michigan | 49620 | — |
| Methodist Phys. Clinic | Omaha | Nebraska | 68114 | — |
| Univ of Nebraska Medical CTR | Omaha | Nebraska | 68198-3020 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89128 | — |
| Dartmouth-Hitchcock Med Ctr | Lebanon | New Hampshire | 03766 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03060 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| Great Lakes Medical Research | Westfield | New York | 14787 | — |
| Mountain Diabetes & Endocrine Center | Asheville | North Carolina | 28803 | — |
| Kernodle Clin Dpt-Pvt Diagnost | Burlington | North Carolina | 27215 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest Life Sciences LLC | Greensboro | North Carolina | 27408 | — |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | — |
| Eastern Nephr Assoc, PLLC | New Bern | North Carolina | 28562 | — |
| Whiteville Medical Associates | Whiteville | North Carolina | 28472 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Lillestol Research LLC | Fargo | North Dakota | 58104 | — |
| Awasty Research Network,LLC | Marion | Ohio | 43302 | — |
| Advanced Med Res Maumee | Maumee | Ohio | 43537 | — |
| Your Diabetes Endocrine Nutrition Group, Inc. | Mentor | Ohio | 44060 | — |
| Twinsburg Family Health Center | Twinsburg | Ohio | 44087 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Heritage Valley Medical Group Inc | Beaver | Pennsylvania | 15009 | — |
| Primary Care Research South, Inc | McMurray | Pennsylvania | 15317 | — |
| Aria Endocrine Metabolic Assoc | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians Inc. | Pittsburgh | Pennsylvania | 15243 | — |
| The Diabetes Center, LLC | Murrells Inlet | South Carolina | 29576 | — |
| Carolina Health Specialists | Myrtle Beach | South Carolina | 29572 | — |
| Spartanburg Medical Research | Spartanburg | South Carolina | 29303 | — |
| Michael L Reeves, MD | Chattanooga | Tennessee | 37404 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| InvestiClin Research | Nashville | Tennessee | 37203 | — |
| MidState Endocrine Associates | Nashville | Tennessee | 37203 | — |
| Vanderbilt Diab Obes Clin Tri | Nashville | Tennessee | 37212 | — |
| Trinity Clinical Research LLC | Tullahoma | Tennessee | 37388 | — |
| Arlington Family Res. Ctr Inc | Arlington | Texas | 76012-4637 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Texas Diabetes & Endocrinology, P.A._Austin | Austin | Texas | 78731 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| Diabetes and Thyroid Ctr of FW | Fort Worth | Texas | 76132 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Synergy Groups Medical | Houston | Texas | 77061 | — |
| DCOL Ctr for Clin Res | Longview | Texas | 75605 | — |
| Midland Clinical Research Center | Midland | Texas | 79707 | — |
| Texas Diabetes & Endocrinology, P.A._Austin | Round Rock | Texas | 78681 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Hillcrest Family Health Center | Waco | Texas | 76708 | — |
| Dominion Medical Associates | Richmond | Virginia | 23219 | — |
| Selma Medical Associates | Winchester | Virginia | 22601-3834 | — |
| Clinical Investigation Spec. Kenosha | Kenosha | Wisconsin | 60031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 401 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03914326, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 10, 2025 · Synced Sep 27, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03914326 live on ClinicalTrials.gov.