ClinicalTrials.gov record
An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
ClinicalTrials.gov ID: NCT03915951
Public ClinicalTrials.gov record NCT03915951. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:26 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer
Study identification
- NCT ID
- NCT03915951
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 98 participants
Conditions and interventions
Conditions
Interventions
- binimetinib Drug
- encorafenib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 3, 2019
- Primary completion
- Sep 21, 2022
- Completion
- Oct 2, 2025
- Last update posted
- Mar 23, 2026
2019 – 2025
United States locations
- U.S. sites
- 112
- U.S. states
- 18
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Yuma Regional Medical Center Cancer Center | Yuma | Arizona | 85364 | — |
| Yuma Regional Medical Center Ophthalmology | Yuma | Arizona | 85364 | — |
| Yuma Regional Medical Center | Yuma | Arizona | 85364 | — |
| UCLA Hematology/Oncology | Los Angeles | California | 90095 | — |
| UCLA Stein Eye Center Santa Monica (OPH) | Santa Monica | California | 90403 | — |
| UCLA Hematology/Oncology | Santa Monica | California | 90404 | — |
| Florida Cancer Specialist | Altamonte Springs | Florida | 32701 | — |
| Florida Cancer Specialists | Bonita Springs | Florida | 34135 | — |
| Florida Cancer Specialist | Brandon | Florida | 33511 | — |
| Florida Cancer Specialists | Cape Coral | Florida | 33909 | — |
| Florida Cancer Specialist | Clearwater | Florida | 33761 | — |
| Florida Cancer Specialists | Fleming Island | Florida | 32003 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33905 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33916 | — |
| Florida Cancer Specialist | Gainesville | Florida | 32605 | — |
| Florida Cancer Specialists | Largo | Florida | 33770 | — |
| Florida Cancer Specialist | Lecanto | Florida | 34461 | — |
| Florida Cancer Specialists | Naples | Florida | 34102 | — |
| Florida Cancer Specialist | Ocala | Florida | 34474 | — |
| Florida Cancer Specialist | Orange City | Florida | 32763 | — |
| Florida Cancer Specialist | Orlando | Florida | 32806 | — |
| Florida Cancer Specialists | Port Charlotte | Florida | 33980 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists | Sarasota | Florida | 34236 | — |
| Florida Cancer Specialists | Spring Hill | Florida | 34608 | — |
| Florida Cancer Specialist | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists PAN - SCRI - PPDS | Tallahassee | Florida | 32308 | — |
| Florida Cancer Specialist | Tampa | Florida | 33607 | — |
| Florida Cancer Specialist | Tavares | Florida | 32778 | — |
| Florida Cancer Specialist | The Villages | Florida | 32159 | — |
| Florida Cancer Specialist | Trinity | Florida | 34655 | — |
| Florida Cancer Specialists | Venice | Florida | 34285 | — |
| Florida Cancer Specialists | Venice | Florida | 34292 | — |
| Florida Cancer Specialists | Winter Park | Florida | 32792 | — |
| Winship Cancer Institute @ Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Winship Cancer Institute @ Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Winship Cancer Institute @ Emory Johns Creek Hospital | Johns Creek | Georgia | 30097 | — |
| Memorial Hospital | Shiloh | Illinois | 62269 | — |
| Siteman Cancer Center - Shiloh | Shiloh | Illinois | 62269 | — |
| MidAmerica Division, Inc. c/o Menorah Medical Center | Overland Park | Kansas | 66209 | — |
| Johns Hopkins Bayview Medical Center | Baltimore | Maryland | 21224 | — |
| Johns Hopkins Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21231 | — |
| The Johns Hopkins Wilmer Eye Institute | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Ophthalmic Consultants of Boston (OCB) | Boston | Massachusetts | 02114 | — |
| Ophthalmic Consultants of Boston Inc | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Dana Farber / Partners Cancer Care | Boston | Massachusetts | 02115 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | — |
| Beth Israel Deaconess Medical Center/East | Boston | Massachusetts | 02215 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Dana-Farber Cancer Institute - Chestnut Hill | Newton | Massachusetts | 02459 | — |
| Siteman Cancer Center - St Peters | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | — |
| MidAmerica Division, Inc. c/o Centerpoint Medical Center | Independence | Missouri | 64057 | — |
| MidAmerica Division, Inc., c/o Research Medical Center | Kansas City | Missouri | 64132 | — |
| Siteman Cancer Center | St Louis | Missouri | 63108 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Saint Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Memorial Sloan Kettering Cancer Center Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Hackensack University Medical Center | Edison | New Jersey | 08837 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Regional Cancer Care Associates, LLC | Hackensack | New Jersey | 07601 | — |
| Metropolitan Eye Care | Paramus | New Jersey | 07652 | — |
| Memorial Sloan Kettering Cancer Center David H Koch Center for Cancer Care | New York | New York | 10021 | — |
| Weill Cornell Eye Associates | New York | New York | 10021 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10021 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10065 | — |
| Duke Cancer Center | Durham | North Carolina | 27710 | — |
| Ohio State CarePoint East | Columbus | Ohio | 43203 | — |
| The Ohio State University East Hospital | Columbus | Ohio | 43203 | — |
| The Ohio State University Hospital | Columbus | Ohio | 43210 | — |
| The Ohio State University James Cancer Hospital | Columbus | Ohio | 43210 | — |
| The Ohio State University Medical Center - Thoracic Oncology Clinic | Columbus | Ohio | 43210 | — |
| Ohio State Eye and Ear Institute | Columbus | Ohio | 43212 | — |
| Stefanie Spielman Comprehensive Breast Cancer | Columbus | Ohio | 43212 | — |
| Martha Morehouse Medical Plaza | Columbus | Ohio | 43221 | — |
| Ohio State CarePoint Gahanna | Gahanna | Ohio | 43230 | — |
| Ohio State Outpatient Care Lewis Center | Lewis Center | Ohio | 43035 | — |
| The Ohio State University East Hospital Ohio State Outpatient Care New Albany | Westerville | Ohio | 43081 | — |
| Providence Cancer Institute Clackamas Clinic | Clackamas | Oregon | 97015 | — |
| Providence Cancer Institute Newberg Clinic | Newberg | Oregon | 97132 | — |
| Providence Cancer Institute, Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Oncology and Hematology Care Clinic - Westside | Portland | Oregon | 97225 | — |
| UPMC Hillman Cancer Center Erie | Erie | Pennsylvania | 16505 | — |
| UPMC Hillman Cancer Center - Arnold Palmer - Mt View | Greensburg | Pennsylvania | 15601 | — |
| UPMC Hillman Cancer Center Monroeville | Monroeville | Pennsylvania | 15146 | — |
| UPMC Eye Center, Eye and Ear Institute | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| UPMC Hillman Cancer Center - Passavant (HOA) | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center - Passavant (OHA) | Pittsburgh | Pennsylvania | 15237 | — |
| UPMC Hillman Cancer Center - Upper St. Clair | Pittsburgh | Pennsylvania | 15243 | — |
| Weaver Eye Associates | York | Pennsylvania | 17402 | — |
| WellSpan Health | York | Pennsylvania | 17403 | — |
| WellSpan Oncology Research | York | Pennsylvania | 17403 | — |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | — |
| Tennessee Oncology, PLLC | Cleveland | Tennessee | 37311 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Shelbyville | Tennessee | 37160 | — |
| Houston Eye Associates - Gramercy Location | Houston | Texas | 77008 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Millennium Research & Clinical Development | Houston | Texas | 77090 | — |
| Eye associates Northwest | Seattle | Washington | 98104 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 31 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03915951, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 23, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03915951 live on ClinicalTrials.gov.