Patient-Reported and Radiographic Outcomes in Evaluating Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis
Public ClinicalTrials.gov record NCT03928184. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 56-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of a Single Injection of SM04690 Injected in the Target Knee Joint of Moderately to Severely Symptomatic Osteoarthritis Subjects
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 3 study is a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target knee (most painful) joint of moderately to severely symptomatic osteoarthritis (OA) subjects at a single dose of 0.07 mg lorecivivint per 2 mL injection. This study will utilize radiographs and patient reported outcomes (PROs) to evaluate the safety and efficacy of lorecivivint.
Study identification
- NCT ID
- NCT03928184
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 501 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 17, 2019 (Actual)
- Primary completion
- Aug 20, 2021 (Actual)
- Completion
- Aug 20, 2021 (Actual)
- Last update posted
- Feb 13, 2026
2019 – 2021
United States locations
- U.S. sites
- 99
- U.S. states
- 30
- U.S. cities
- 88
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Birmingham | Alabama | 35205 | — |
| Research Site | Birmingham | Alabama | 35215 | — |
| Research Site | Birmingham | Alabama | 35216 | — |
| Research Site | Peoria | Arizona | 85381 | — |
| Research Site | Phoenix | Arizona | 85037 | — |
| Research Site | Tucson | Arizona | 85712 | — |
| Research Site | Little Rock | Arkansas | 72205 | — |
| Research Site | Anaheim | California | 92805 | — |
| Research Site | Garden Grove | California | 92840 | — |
| Research Site | Norco | California | 92860 | — |
| Research Site | Pomona | California | 91767 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | San Marcos | California | 92078 | — |
| Research Site | Spring Valley | California | 91978 | — |
| Research Site | Westminster | California | 92683 | — |
| Research Site | Boulder | Colorado | 80301 | — |
| Research Site | Colorado Springs | Colorado | 80918 | — |
| Research Site | Denver | Colorado | 80209 | — |
| Research Site | Waterbury | Connecticut | 06708 | — |
| Research Site | Clearwater | Florida | 33761 | — |
| Research Site | Coral Gables | Florida | 33134 | — |
| Research Site | Hialeah | Florida | 33016 | — |
| Research Site | Miami | Florida | 33143 | — |
| Research Site | Miami Lakes | Florida | 33014 | — |
| Research Site | Orlando | Florida | 32806 | — |
| Research Site | Oviedo | Florida | 32765 | — |
| Research Site | Port Orange | Florida | 32127 | — |
| Research Site | Sunrise | Florida | 33351 | — |
| Research Site | West Palm Beach | Florida | 33409 | — |
| Research Site | Winter Haven | Florida | 33880 | — |
| Research Site #1 | Winter Park | Florida | 32789 | — |
| Research Site #2 | Winter Park | Florida | 32789 | — |
| Research Site | Marietta | Georgia | 30060 | — |
| Research Site | Newnan | Georgia | 30265 | — |
| Research Site | Stockbridge | Georgia | 30281 | — |
| Research Site | Woodstock | Georgia | 30189 | — |
| Research Site | Boise | Idaho | 83713 | — |
| Research Site | Meridian | Idaho | 83642 | — |
| Research Site | Bloomington | Illinois | 61704 | — |
| Research Site | Gurnee | Illinois | 60031 | — |
| Research Site | Oak Brook | Illinois | 60523 | — |
| Research Site | Rockford | Illinois | 61114 | — |
| Research Site | Anderson | Indiana | 46011 | — |
| Research Site | Evansville | Indiana | 47714 | — |
| Research Site | Valparaiso | Indiana | 46383 | — |
| Research Site | Kansas City | Kansas | 66160 | — |
| Research Site | Wichita | Kansas | 67205 | — |
| Research Site | Monroe | Louisiana | 71203 | — |
| Research Site | New Orleans | Louisiana | 70124 | — |
| Research Site | Wheaton | Maryland | 20902 | — |
| Research Site | Boston | Massachusetts | 02111 | — |
| Research Site | Bay City | Michigan | 48706 | — |
| Research Site | Troy | Michigan | 48085 | — |
| Research Site | Hazelwood | Missouri | 63042 | — |
| Research Site | St Louis | Missouri | 63141 | — |
| Research Site | La Vista | Nebraska | 68128 | — |
| Research Site | Lincoln | Nebraska | 68516 | — |
| Research Site | Omaha | Nebraska | 68114 | — |
| Research Site | Albuquerque | New Mexico | 87108 | — |
| Research Site | Great Neck | New York | 11021 | — |
| Research Site | Hartsdale | New York | 10530 | — |
| Research Site | New York | New York | 10016 | — |
| Research Site 1 | New York | New York | 10021 | — |
| Research Site 2 | New York | New York | 10021 | — |
| Research Site | Rochester | New York | 14609 | — |
| Research Site | Williamsville | New York | 14221 | — |
| Research Site | Charlotte | North Carolina | 28209 | — |
| Research Site | Leland | North Carolina | 28451 | — |
| Research Site | Salisbury | North Carolina | 28144 | — |
| Research Site | Winston-Salem | North Carolina | 27103 | — |
| Research Site | Fargo | North Dakota | 58104 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cincinnati | Ohio | 45224 | — |
| Research Site | Cincinnati | Ohio | 45242 | — |
| Research Site | Columbus | Ohio | 43235 | — |
| Research Site | Oklahoma City | Oklahoma | 73103 | — |
| Research Site | Oklahoma City | Oklahoma | 73112 | — |
| Research Site | Duncansville | Pennsylvania | 16635 | — |
| Research Site | Fort Mill | South Carolina | 29707 | — |
| Research Site | Greenville | South Carolina | 29607 | — |
| Research Site | Greer | South Carolina | 29651 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | Rapid City | South Dakota | 57702 | — |
| Research Site | Austin | Texas | 78745 | — |
| Research Site | Bedford | Texas | 76021 | — |
| Research Site | Carrollton | Texas | 75007 | — |
| Research Site | Dallas | Texas | 75231 | — |
| Research Site | Edinburg | Texas | 78539 | — |
| Research Site | Houston | Texas | 77029 | — |
| Research Site | Houston | Texas | 77055 | — |
| Research Site | Plano | Texas | 75075 | — |
| Research Site | San Antonio | Texas | 78215 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | San Antonio | Texas | 78258 | — |
| Research Site | Draper | Utah | 84020 | — |
| Research Site | Murray | Utah | 84123 | — |
| Research Site | Salt Lake City | Utah | 84107 | — |
| Research Site | Charlottesville | Virginia | 22911 | — |
| Research Site | Richmond | Virginia | 23219 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03928184, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 13, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03928184 live on ClinicalTrials.gov.