Assessment of the Safety and Efficacy of RGN-259 Ophthalmic Solutions for Dry Eye Syndrome: ARISE-3
Public ClinicalTrials.gov record NCT03937882. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multi-Center, Randomized, Double Masked, Placebo Controlled Clinical Study to Assess the Safety and Efficacy of RGN-259 Ophthalmic Solutions for the Treatment of Dry Eye (ARISE-3)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The objective of this study is to compare the safety and efficacy of RGN-259 Ophthalmic Solution to placebo for the treatment of the signs and symptoms of dry eye.
Study identification
- NCT ID
- NCT03937882
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 700 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 24, 2019 (Actual)
- Primary completion
- Nov 8, 2020 (Actual)
- Completion
- Oct 7, 2021 (Actual)
- Last update posted
- Aug 28, 2026
2019 – 2021
United States locations
- U.S. sites
- 20
- U.S. states
- 16
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cornea and Cataract Consultants of Arizona | Phoenix | Arizona | 85032 | — |
| Eye Research Foundation | Newport Beach | California | 92663 | — |
| Vision Institute | Colorado Springs | Colorado | 80907 | — |
| Dovilan Wyatt MD, LLC | Chicago | Illinois | 60619 | — |
| Whitson Vision | Indianapolis | Indiana | 46240 | — |
| Midwest Cornea Associates, LLC | Indianapolis | Indiana | 46290 | — |
| The Eye Care Institute | Louisville | Kentucky | 40206 | — |
| Andover Eye Associates | Andover | Massachusetts | 01810 | — |
| Andover Eye Associates | Raynham | Massachusetts | 02767 | — |
| Center For Sight | Henderson | Nevada | 89052 | — |
| Oculus Research, Inc. at the Eye Care Center | Raleigh | North Carolina | 27603 | — |
| Visual Eyes Optometric | Shelby | North Carolina | 28150 | — |
| Bergstrom Eye Research, LLC | Fargo | North Dakota | 58103 | — |
| Scott & Christie and Associates, PC | Cranberry Township | Pennsylvania | 16066 | — |
| Andover Eye Associates | Warwick | Rhode Island | 02886 | — |
| Total Eye Care, P.A. | Memphis | Tennessee | 38119 | — |
| Texan Eye/Keystone Research | Austin | Texas | 78731 | — |
| Mountain View Eye Center | Layton | Utah | 84041 | — |
| Country Hills Eye Center | Ogden | Utah | 84403 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03937882, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 28, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT03937882 live on ClinicalTrials.gov.