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Terminated Phase 1Phase 2 Interventional

A Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

ClinicalTrials.gov ID: NCT03970616

Public ClinicalTrials.gov record NCT03970616. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 20, 2026, 8:50 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1b/2, Open-Label, Study of Tivozanib in Combination With Durvalumab in Subjects With Advanced Hepatocellular Carcinoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will evaluate the safety, tolerability, DLTs, MTD, and preliminary anti tumor activity of tivozanib in combination with durvalumab in subjects with advanced HCC.

Study identification

NCT ID
NCT03970616
Recruitment status
Terminated
Study type
Interventional
Phase
Phase 1, Phase 2
Lead sponsor
AVEO Pharmaceuticals, Inc.
Industry
Enrollment
27 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Sep 30, 2019 (Actual)
Primary completion
Apr 4, 2023 (Actual)
Completion
Apr 4, 2023 (Actual)
Last update posted
Jul 12, 2023

2019 – 2023

United States locations

U.S. sites
10
U.S. states
6
U.S. cities
10
Facility City State ZIP Site status
Banner MD Anderson Cancer Center Gilbert Arizona 85234 —
City of Hope Duarte California 91010 —
University of California - Irvine Orange California 92868 —
Northwestern University Feinberg School of Medicine Chicago Illinois 60611 —
Dana Farber Cancer Institute Boston Massachusetts 02215 —
Roswell Park Cancer Institute Buffalo New York 14263 —
Montefiore Medical Center The Bronx New York 10467 —
UT Southwestern Medical Center Dallas Texas 75390 —
The University of Texas Health Science Center at Houston (UTHealth) Houston Texas 77030 —
The University of Texas Health Science Center at Tyler (UTHealth) Tyler Texas 75708 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT03970616, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 12, 2023 · Synced Oct 20, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT03970616 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →