A Trial to Find Out if REGN5678 (Nezastomig) is Safe and How Well it Works Alone or in Combination With Cemiplimab for Adult Participants With Metastatic Castration-Resistant Prostate Cancer and Other Tumors
Public ClinicalTrials.gov record NCT03972657. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Study of REGN5678 (Anti-PSMAxCD28) With or Without Cemiplimab (Anti-PD-1) in Patients With Metastatic Castration-Resistant Prostate Cancer and Other Tumors Associated With PSMA Expression
Study identification
- NCT ID
- NCT03972657
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Regeneron Pharmaceuticals
- Industry
- Enrollment
- 345 participants
Conditions and interventions
Conditions
Interventions
- Cemiplimab Drug
- REGN5678 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 11, 2019
- Primary completion
- Nov 14, 2027
- Completion
- Nov 14, 2027
- Last update posted
- Nov 5, 2025
2019 – 2027
United States locations
- U.S. sites
- 21
- U.S. states
- 13
- U.S. cities
- 17
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| Mayo Clinic | Phoenix | Arizona | 85054 | Recruiting |
| University of Arizona | Tucson | Arizona | 85724 | Recruiting |
| John Wayne Cancer Institute (JWCI) | Santa Monica | California | 90404 | Recruiting |
| Sarah Cannon Research Institute (SCRI) | Denver | Colorado | 80218 | Recruiting |
| Yale University Hospital | New Haven | Connecticut | 06510 | Recruiting |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| Moffitt Cancer Center - McKinley Drive | Tampa | Florida | 33612 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| NYU Langone Health Perlmutter Cancer Center | New York | New York | 10016 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Columbia University - The Trustees of Columbia University in the City of New York | New York | New York | 10032 | Recruiting |
| Montefiore Medical Center | New York | New York | 10461 | Recruiting |
| University of Rochester Medical Center (URMC) - Wilmot Cancer Institute (WCI) (James P. Wilmot Cancer Center) - Rochester | Rochester | New York | 14642 | Recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Withdrawn |
| Oregon Health & Science University (3485 S. Bond) | Portland | Oregon | 97239 | Recruiting |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Lifespan Cancer Institute | Providence | Rhode Island | 02903 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Emily Couric Clinical Cancer Center | Charlottesville | Virginia | 22908 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03972657, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 5, 2025 · Synced May 17, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03972657 live on ClinicalTrials.gov.