ClinicalTrials.gov record
Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)
ClinicalTrials.gov ID: NCT03988634
Public ClinicalTrials.gov record NCT03988634. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blind, Double Dummy, Parallel Group, Active-controlled Study to Evaluate the Effect of Sacubitril/Valsartan (LCZ696) Versus Valsartan on Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The effect of sacubitril/valsartan vs. valsartan on changes in NT-proBNP, safety, and tolerability in HFpEF patients with a WHF event (HFpEF decompensation) who had been stabilized and initiated at the time of or within 30 days post-decompensation.
Study identification
- NCT ID
- NCT03988634
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 467 participants
Conditions and interventions
Interventions
- sacubitril/valsartan Drug
- valsartan Drug
- sacubitril/valsartan matching placebo Drug
- valsartan matching placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 28, 2019
- Primary completion
- Dec 13, 2022
- Completion
- Dec 13, 2022
- Last update posted
- Mar 5, 2025
2019 – 2022
United States locations
- U.S. sites
- 87
- U.S. states
- 33
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Calif Irvine Med Cntr | Irvine | California | 92660 | — |
| Memorial Care Health System Memorialcare Long Beach | Long Beach | California | 90806 | — |
| University Of Southern California . | Los Angeles | California | 90033-4605 | — |
| University Of Southern California | Los Angeles | California | 90033-4605 | — |
| San Diego Cardiac Center | San Diego | California | 92123 | — |
| Zuckerberg General W84 Research . | San Francisco | California | 94110 | — |
| Sutter Health Network . | San Pablo | California | 94806 | — |
| Helping Hands Medical Associates INC | Santa Ana | California | 92704 | — |
| St Francis Medical Center | Colorado Springs | Colorado | 80923 | — |
| Colorado Heart and Vascular . | Lakewood | Colorado | 80228 | — |
| South Denver Cardiology Associates PC | Littleton | Colorado | 80120 | — |
| Hartford Healthcare Headache Center | West Hartford | Connecticut | 06109 | — |
| VA Connecticut Healthcare System | West Haven | Connecticut | 06516 | — |
| Cardiology Physicians PA . | Newark | Delaware | 19713 | — |
| University of Florida Health . | Gainesville | Florida | 32610 | — |
| New Generation of Medical Research Avera Health N Central Heart | Hialeah | Florida | 33016 | — |
| University of Florida Health Science Center | Jacksonville | Florida | 32209 | — |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | — |
| Morehouse School Of Medicine | Atlanta | Georgia | 30310 | — |
| Emory University School of Medicine/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| University Cardiology Associates | Augusta | Georgia | 30901 | — |
| St Lukes Idaho Cardiology Associates CLCZ696BUS13 | Boise | Idaho | 83702 | — |
| University of Chicago . | Chicago | Illinois | 60637 | — |
| Amita Health | Elk Grove Village | Illinois | 60007 | — |
| Midwest Cardiovascular Institute . | Oakbrook Terrace | Illinois | 60181 | — |
| Advocate Medical Group . | Park Ridge | Illinois | 60068 | — |
| Unity Point Health Methodist | Peoria | Illinois | 61606 | — |
| OSF HealthCare | Peoria | Illinois | 61614 | — |
| Northwestern Medicine Northwestern University | Winfield | Illinois | 60190 | — |
| Midwest Cardiovascular Research and Education Foundation . | Elkhart | Indiana | 46514 | — |
| Indiana University Health | Indianapolis | Indiana | 46202 | — |
| Franciscan Health Services Research Center . | Indianapolis | Indiana | 46237 | — |
| Indiana University Health | Muncie | Indiana | 47303 | — |
| Reid Hosp And Hlth Care Services | Richmond | Indiana | 47374 | — |
| The Uni of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Alexandria Cardiology Clinic | Alexandria | Louisiana | 71301 | — |
| The Franciscan Missionaries | Baton Rouge | Louisiana | 70808 | — |
| Northern Light Easter Maine Medical Center . | Bangor | Maine | 04401 | — |
| Johns Hopkins Univ School of Med | Baltimore | Maryland | 21287 | — |
| Tidal Health Peninsula Regional Inc . | Salisbury | Maryland | 21804 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Boston Univeristy Medical Center . | Boston | Massachusetts | 02118 | — |
| Beth Israel Deaconess Med Ctr CLCZ696D2301 | Boston | Massachusetts | 02215 | — |
| University of Michigan Hs | Ann Arbor | Michigan | 48109 | — |
| Detroit Medical Center Cardiovascular Clinical Trial . | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital Cardiovascular Medicine | Detroit | Michigan | 48202 | — |
| Trinity Health Michigan Heart . | Ypsilanti | Michigan | 48197 | — |
| Novartis Investigative Site | Saint Paul | Minnesota | 55101 | — |
| Jackson Heart Clinic | Jackson | Mississippi | 39216 | — |
| Nebraska Heart Institute CHI Health Nebraska | Lincoln | Nebraska | 68510 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Univ Medical Center Las Vegas | Las Vegas | Nevada | 89201 | — |
| R Ins For Heart And Vascular Health | Reno | Nevada | 89502 | — |
| Inspira Health Network | Elmer | New Jersey | 08318 | — |
| Cooper University Health Care | Haddon Heights | New Jersey | 08035 | — |
| Saint Michael Medical Center | Newark | New Jersey | 07102 | — |
| Cedar Multi-Specialty Clinic | Albuquerque | New Mexico | 87106 | — |
| Albany Associates In Cardiology | Albany | New York | 12205 | — |
| New York Presbyterian Queens . | Flushing | New York | 11355 | — |
| United Health Services Office Of Clinical Trails CLCZ696BUS01 | Johnson | New York | 13790 | — |
| Northwell Health . | Manhasset | New York | 11030 | — |
| Mount Sinai Hospital . | New York | New York | 10029 | — |
| HealthQuest | Poughkeepsie | New York | 12601 | — |
| Catholic Hlth Svcs of Long Island | Roslyn | New York | 11576 | — |
| Mount Sinai Health System | Staten Island | New York | 10310 | — |
| Stony Brook University Medical Center CLCZ696G2301 | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center . | The Bronx | New York | 10461 | — |
| University Of North Carolina At Chapel Hill CRLX030A2209 | Chapel Hill | North Carolina | 27599-7075 | — |
| Duke Health | Durham | North Carolina | 27710 | — |
| Cleveland Clinic Foundation . | Cleveland | Ohio | 44195 | — |
| St. Vincent Mercy Medical Center | Toledo | Ohio | 43608 | — |
| St John Health System | Bartlesville | Oklahoma | 74006 | — |
| Regional Medical Labaratory | Tulsa | Oklahoma | 74104 | — |
| Jefferson Abington . | Abington | Pennsylvania | 19001 | — |
| Allegheny Valley Hospital . | Natrona Heights | Pennsylvania | 15065 | — |
| Capital Area Research LLC CACZ885M2301 | Newport | Pennsylvania | 17074 | — |
| Thomas Jefferson Univ Hospital . | Philadelphia | Pennsylvania | 19107 | — |
| Regional Health Clinic Research . | Rapid City | South Dakota | 57701 | — |
| North Central Heart . | Sioux Falls | South Dakota | 57105 | — |
| VA Tennessee Valley Healthcare System | Nashville | Tennessee | 37212 | — |
| Pharma Tex Research . | Amarillo | Texas | 79106 | — |
| Baylor University Medical Center . | Dallas | Texas | 75246 | — |
| The University of Texas Medical Branch | Galveston | Texas | 77555-1062 | — |
| The University of Vermont Medical Center CRLX030A2301 | Burlington | Vermont | 05401 | — |
| Centra Health | Lynchburg | Virginia | 24501 | — |
| Swedish Medical Ctr Cardiovascular Re | Seattle | Washington | 98122 | — |
| University of Wisconsin School of Medicine and Public Health CLCZ696BUS01 | Madison | Wisconsin | 53792-1615 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT03988634, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 5, 2025 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT03988634 live on ClinicalTrials.gov.