Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

ClinicalTrials.gov ID: NCT04031677

Public ClinicalTrials.gov record NCT04031677. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 2:37 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients With High Risk RetroPeritoneal Sarcoma (RPS)

Study identification

NCT ID: NCT04031677
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: European Organisation for Research and Treatment of Cancer - EORTC; Network
Enrollment: 250 participants

Conditions and interventions

Conditions

Interventions

Preoperative chemotherapy Drug
Surgery Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 19, 2021
Primary completion: Apr 20, 2027
Completion: Apr 20, 2028
Last update posted: Mar 30, 2026

2021 – 2028

United States locations

U.S. sites: 106
U.S. states: 37
U.S. cities: 86

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Withdrawn
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
UCI Health-Chao Family Comp CC and Ambulatory Care	Irvine	California	92612	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
UC Irvine Health/Chao Family Comprehensive Ca Ctr	Orange	California	92668	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	06418	Recruiting
Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	06824	Recruiting
Smilow Cancer Hospital Care Center at Glastonbury	Glastonbury	Connecticut	06033	Recruiting
Smilow Cancer Hospital Care Center at Greenwich	Greenwich	Connecticut	06830	Recruiting
Smilow Cancer Hospital Care Center - Guiford	Guilford	Connecticut	06437	Recruiting
Smilow Cancer Hospital Care Ctr at Saint Francis	Hartford	Connecticut	06105	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	06385	Recruiting
Smilow Cancer Hospital Care Center at Long Ridge	Stamford	Connecticut	06902	Recruiting
Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	06611	Recruiting
Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	06708	Recruiting
Smilow Cancer Hospital Care Center - Waterford	Waterford	Connecticut	06385	Recruiting
Univ of Florida Health Science Ctr - Gainesville	Gainesville	Florida	32610	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224	Recruiting
Moffitt Cancer Center-International Plaza	Tampa	Florida	33607	Recruiting
Moffitt Cancer Center - McKinley Campus	Tampa	Florida	33612	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Northwestern University	Chicago	Illinois	60611	Withdrawn
Rush University Medical Center	Chicago	Illinois	60612	Recruiting
University of Illinois at Chicago MBCCOP	Chicago	Illinois	60612	Recruiting
Indiana Univ/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Withdrawn
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	66210	Recruiting
University of Kansas Hospital-Westwood Cancer Ctr	Westwood	Kansas	66205	Recruiting
James Graham Brown Ca Ctr at Univ of Louisville	Louisville	Kentucky	40202	Recruiting
UofL Health Medical Center Northeast	Louisville	Kentucky	40245	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of The Lake Hospital	Baton Rouge	Louisiana	70808	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
Johns Hopkins Univ/Sidney Kimmel Cancer Center	Baltimore	Maryland	21205	Withdrawn
Dana-Farber/Harvard Cancer Center	Boston	Massachusetts	02215	Recruiting
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Sanford Joe Lueken Cancer Center	Bemidji	Minnesota	56601	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Siteman Cancer Center-West County	Creve Coeur	Missouri	63141	Recruiting
Washington University School of Medicine - Siteman Cancer Center	St Louis	Missouri	63110	Recruiting
Siteman Cancer Center-South Country	St Louis	Missouri	63129	Recruiting
Nebraska Medicine-Bellevue	Bellevue	Nebraska	68123	Recruiting
Nebraska Medicine-Bellevue	Omaha	Nebraska	68118	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Renown Regional Medical Center	Reno	Nevada	89502	Recruiting
Dartmouth Hitchcock Med Ctr/Dartmouth Cancer Ctr	Lebanon	New Hampshire	03756	Withdrawn
Cooper Hospital University Medical Center	Camden	New Jersey	08103	Recruiting
HMH-Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
John Theurer Cancer Center at From Road	Paramus	New Jersey	07652	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
Laura and Issac Perlmutter Ca Ctr at NYU Langone	New York	New York	10016	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Stony Brook University Medical Center	Stony Brook	New York	11794	Recruiting
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Sanford Bismarck Medical Center	Bismarck	North Dakota	58501	Withdrawn
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Withdrawn
Sanford Roger Maris Cancer Center	Fargo	North Dakota	58122	Withdrawn
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Saint Vincent Hospital	Erie	Pennsylvania	16544	Recruiting
Jefferson Hospital	Jefferson Hills	Pennsylvania	15025	Recruiting
Forbes Hospital	Monroeville	Pennsylvania	15146	Recruiting
Allegheny Valley Hospital	Natrona Heights	Pennsylvania	15065	Recruiting
University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	19104	Recruiting
Pennsylvania Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Thomas Jefferson University Hospital	Philadelphia	Pennsylvania	19107	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Recruiting
West Penn Hospital	Pittsburgh	Pennsylvania	15224	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Wexford Health and Wellness Pavilion	Wexford	Pennsylvania	15090	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Smilow Cancer Hospital Care Center - Westerly	Westerly	Rhode Island	02891	Recruiting
Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	57104	Withdrawn
Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	57117	Withdrawn
University of Tennessee - Knoxville	Knoxville	Tennessee	37920	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84132	Recruiting
University of Vermont Medical Center	Burlington	Vermont	05401	Recruiting
Vermont Regional Cancer Center	Burlington	Vermont	05405	Recruiting
VCU Massey Cancer Center at Hanover Medical Park	Mechanicsville	Virginia	23116	Recruiting
VCU Massey Cancer Center at Stony Point	Richmond	Virginia	23235	Recruiting
Virginia Commonwealth Univ/Massey Cancer Center	Richmond	Virginia	23298	Recruiting
Carilion Roanoke Memorial Hospital	Roanoke	Virginia	24014	Recruiting
VCU Community Memorial Health Center	South Hill	Virginia	23970	Withdrawn
FHCC South Lake Union	Seattle	Washington	98109	Withdrawn
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
University of Washington Medical Center - Montlake	Seattle	Washington	98195	Recruiting
Marshfield Medical Center-EC Cancer Center	Eau Claire	Wisconsin	54701	Recruiting
Marshfield Medical Center	Marshfield	Wisconsin	54449	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting
Marshfield Medical Center	Minocqua	Wisconsin	54548	Recruiting
Marshfield Medical Center	Rice Lake	Wisconsin	54868	Recruiting
Marshfield Med Ctr-River Region at Stevens Point	Stevens Point	Wisconsin	54482	Recruiting
Marshfield Medical Center	Weston	Wisconsin	54476	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 58 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04031677, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 30, 2026 · Synced May 7, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04031677 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →