Intravenous Iloprost in Subjects With Symptomatic Raynaud's Phenomenon Secondary to Systemic Sclerosis (Phase 3)
Public ClinicalTrials.gov record NCT04040322. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase 3 Study Evaluating the Safety and Efficacy of Intravenous Iloprost in Subjects With Systemic Sclerosis Experiencing Symptomatic Digital Ischemic Episodes (AURORA Study)
Study identification
- NCT ID
- NCT04040322
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Civi Biopharma, Inc.
- Industry
- Enrollment
- 198 participants
Conditions and interventions
Interventions
- Placebo IV infusion Drug
- Iloprost Injection, for intravenous use Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 13, 2019
- Primary completion
- Jun 8, 2021
- Completion
- Jun 8, 2021
- Last update posted
- May 24, 2025
2019 – 2021
United States locations
- U.S. sites
- 30
- U.S. states
- 19
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Arthritis & Rheumatology Research, PLLC | Phoenix | Arizona | 85032 | — |
| Mayo Clinic - Scottsdale | Scottsdale | Arizona | 85259 | — |
| University of Arizona - Arthritis Research Center | Tucson | Arizona | 85724 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California, Los Angeles Medical Center | Los Angeles | California | 90059 | — |
| Stanford University Medical Center | Palo Alto | California | 94305 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| Georgetown University Medical Center - Department of Rheumatology | Washington D.C. | District of Columbia | 20007 | — |
| Northwestern Medical Faculty Foundation | Chicago | Illinois | 60611 | — |
| University Medical Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins University School of Medicine | Baltimore | Maryland | 21224 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| University of Michigan | Ann Arbor | Michigan | 48109-5422 | — |
| West Michigan Rheumatology PLLC | Grand Rapids | Michigan | 49546 | — |
| University of Minnesota Maple Grove | Minneapolis | Minnesota | 55369 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08903 | — |
| Hospital for Special Surgery | New York | New York | 10021 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| University of Cincinnati - Scleroderma Center | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| The University of Toledo Medical Center (UTMC) - Ruppert Health Center | Toledo | Ohio | 43614 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15261 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| University of Texas Houston - Division of Rheumatology and Clinical Immunogenetics | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| Froedtert Hospital and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04040322, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 24, 2025 · Synced Jul 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04040322 live on ClinicalTrials.gov.