A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx
Public ClinicalTrials.gov record NCT04083222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor Administered Subcutaneously for 8 Weeks to Hypertensive Subjects With Uncontrolled Blood Pressure
Study identification
- NCT ID
- NCT04083222
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 26 participants
Conditions and interventions
Conditions
Interventions
- Placebo Drug
- ISIS 757456 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 12, 2019
- Primary completion
- Jul 19, 2020
- Completion
- Jul 19, 2020
- Last update posted
- Jan 17, 2023
2019 – 2020
United States locations
- U.S. sites
- 9
- U.S. states
- 7
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Central Alabama Research | Birmingham | Alabama | 35209 | — |
| National Research Institute - Wilshire | Los Angeles | California | 90057 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| Midwest Institute for Clinical Research | Indianapolis | Indiana | 46260 | — |
| Ohio Clinical Research - Lyndhurst | Lyndhurst | Ohio | 44124 | — |
| Juno Research, LLC | Houston | Texas | 77040 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23510 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04083222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 17, 2023 · Synced Jul 23, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04083222 live on ClinicalTrials.gov.