Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy
Public ClinicalTrials.gov record NCT04083339. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure (ARISE-HF): A Multicenter, Randomized, Placebo-Controlled Study to Evaluate the Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.
Study identification
- NCT ID
- NCT04083339
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 675 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 20, 2019 (Actual)
- Primary completion
- Dec 2023 (Estimated)
- Completion
- Dec 2025 (Estimated)
- Last update posted
- Dec 8, 2022
2019 – 2025
United States locations
- U.S. sites
- 28
- U.S. states
- 12
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Westside Medical Associates of Los Angeles | Beverly Hills | California | 90211 | — |
| University of California, San Diego (UCSD) | La Jolla | California | 92093 | — |
| Clinical Trials Research | Lincoln | California | 95648 | — |
| University of California - Irvine Medical Center | Orange | California | 92868 | — |
| Metabolic Institute of America | Tarzana | California | 91356 | — |
| Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center | Torrance | California | 90509 | — |
| ALL Medical Research, LLC | Cooper City | Florida | 33024 | — |
| New Generation of Medical Research | Hialeah | Florida | 33016 | — |
| Broward Research Center | Pembroke Pines | Florida | 33024 | — |
| Progressive Medical Research | Port Orange | Florida | 32127 | — |
| UnityPoint Health - Methodist Hospital | Peoria | Illinois | 61602 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Universty of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| St. Louis Heart and Vascular Cardiology | St Louis | Missouri | 63136 | — |
| Chear Center LLC | The Bronx | New York | 10455 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Remington Davis, Inc. | Columbus | Ohio | 43215 | — |
| South Oklahoma Heart Research | Oklahoma City | Oklahoma | 73135 | — |
| Mountain View Clinical Research - Greer | Greer | South Carolina | 29651 | — |
| Mountain View Clinical Research | Greer | South Carolina | 29651 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| Southwest Family Medicine Associates | Dallas | Texas | 75235 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| Juno Research, LLC - Northwest Site | Houston | Texas | 77040 | — |
| Juno Research, LLC - Southwest Houston Site | Houston | Texas | 77074 | — |
| FMC Science | Lampasas | Texas | 76550 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04083339, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 8, 2022 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04083339 live on ClinicalTrials.gov.