A Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Colitis
Public ClinicalTrials.gov record NCT04090411. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2B, Multicenter, Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Study to Evaluate The Efficacy, Safety, and Pharmacokinetics of PF-06480605 in Adult Participants With Moderate To Severe Ulcerative Colitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase 2b study is designed to have all subjects go into a 12 week induction period to compare different doses of study drug against placebo. After induction is complete all subjects will receive active therapy for 40 weeks, followed by a 12 week follow up period.
Study identification
- NCT ID
- NCT04090411
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 246 participants
Conditions and interventions
Conditions
Interventions
- Induction- PF-06480605 50 mg SC Q4W Drug
- Induction- PF-06480605 150 mg SC Q4W Drug
- Induction- PF-06480605 450 mg SC Q4W Drug
- Induction- Placebo SC Q4W Other
- Chronic- PF-06480605 50 mg SC Q4W Drug
- Chronic- PF-06480605 150 mg SC Q4W Drug
- Chronic- PF-06480605 450 mg SC Q4W Drug
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 19, 2019 (Actual)
- Primary completion
- Oct 25, 2022 (Actual)
- Completion
- Oct 25, 2022 (Actual)
- Last update posted
- Jul 17, 2026
2019 – 2022
United States locations
- U.S. sites
- 55
- U.S. states
- 18
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Digestive Health Specialists | Dothan | Alabama | 36301 | — |
| Dothan Surgery Center | Dothan | Alabama | 36301 | — |
| Flowers Hospital | Dothan | Alabama | 36305 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | — |
| Surinder Saini, M.D., Inc. | Newport Beach | California | 92660 | — |
| Endoscopy Center of Connecticut, LLC | Guilford | Connecticut | 06437 | — |
| Endoscopy Center of Connecticut, LLC | Hamden | Connecticut | 06518 | — |
| Medical Research Center Of Connecticut, LLC | Hamden | Connecticut | 06518 | — |
| PACT Gastroenterology Center | Hamden | Connecticut | 06518 | — |
| Whitney Imaging | Hamden | Connecticut | 06518 | — |
| Medycal Research Inc. | Brooksville | Florida | 34613 | — |
| Safety Harbor Surgery | Clearwater | Florida | 33761 | — |
| Trident Care | Clearwater | Florida | 33762 | — |
| Tower Radiology Center | Oldsmar | Florida | 34677 | — |
| Akumin | Tampa | Florida | 33603 | — |
| Tampa Bay Endoscopy Center | Tampa | Florida | 33603 | — |
| Alliance Clinical Research of Tampa | Tampa | Florida | 33615 | — |
| Gastroenterology Consultants P.C. | Roswell | Georgia | 30076 | — |
| The University of Chicago Medical Center (clinic address) | Chicago | Illinois | 60637 | — |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| Brigham & Women's Hospital | Boston | Massachusetts | 02115 | — |
| Brigham and Women's Hospital - Office | Boston | Massachusetts | 02115 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Michigan Endoscopy Center | Farmington Hills | Michigan | 48334 | — |
| Valley View Surgery Center | Las Vegas | Nevada | 89102 | — |
| Sierra Clinical Research | Las Vegas | Nevada | 89106 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10021 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| New York Presbyterian Hospital - Weill Cornell Medical Center | New York | New York | 10065 | — |
| Weill Cornell Medical College - New York Presbyterian Hospital | New York | New York | 10065 | — |
| Weill Cornell Medical College- New York Presbyterian Hospital | New York | New York | 10065 | — |
| Investigational Drug Services | Philadelphia | Pennsylvania | 19104 | — |
| Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Gastroenterology Associates, PA of Greenville | Greenville | South Carolina | 29607 | — |
| Vanderbilt GI Endoscopy Lab at One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| Vanderbilt Heart One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| Vanderbilt Inflammatory Bowel Disease Clinic | Nashville | Tennessee | 37204 | — |
| Vanderbilt Laboratory Services North One Hundred Oaks | Nashville | Tennessee | 37204 | — |
| Vanderbilt One Hundred Oaks Imaging | Nashville | Tennessee | 37204 | — |
| Vanderbilt University Medical Center - GI Research Office | Nashville | Tennessee | 37212-1610 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37212 | — |
| Vanderbilt University Med. Center | Nashville | Tennessee | 37232-5543 | — |
| Vanderbilt University Medical Center- Heart Station (ECG) | Nashville | Tennessee | 37232 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Gastroenterology Consultants of San Antonio, PA | San Antonio | Texas | 78230 | — |
| VIP Trials | San Antonio | Texas | 78230 | — |
| South Texas Radiology Imaging Centers | San Antonio | Texas | 78258 | — |
| Gastroenterology Associates of Northern VA | Fairfax | Virginia | 22031 | — |
| Gastroenterology Associates of Northern Virginia | Fairfax | Virginia | 22031 | — |
| Verity Research, Inc. | Fairfax | Virginia | 22031 | — |
| Medical Diagnostic Imaging | Wauwatosa | Wisconsin | 53222 | — |
| Allegiance Internal Medicine and Allegiance Research Specialists | Wauwatosa | Wisconsin | 53226 | — |
| GI Associates | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 111 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04090411, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 17, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04090411 live on ClinicalTrials.gov.