The PROspera Kidney Transplant ACTIVE Rejection Assessment Registry (ProActive)
Public ClinicalTrials.gov record NCT04091984. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The ProActive registry is a longitudinal, multi-center study with a prospective arm observing clinical care for patients receiving physician ordered Prospera, an allograft rejection test, and a historical control arm collecting data on cases at the same sites whose kidney allograft rejection status was managed with Serum Creatinine SCr/estimated Glomerular Filtration Rate eGFR. This registry will compare patient management and outcomes in patients who receive Prospera (Prospera arm) to the outcomes of the historical control group (control arm) to determine Prospera's clinical utility. High-risk subjects defined as having a biopsy-demonstrated rejection event or at least one pre-existing Donor Specific Antibody DSA with total Mean Fluorescent Intensity MFI\>3000 or a calculated Panel Reactive Antibodies cPRA\>70% will be followed for an additional period up to 24 months in both the Prospera arm and historical control arm.
Study identification
- NCT ID
- NCT04091984
- Recruitment status
- Active, not recruiting
- Study type
- Observational
- Phase
- Not listed
- Enrollment
- 5,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 5, 2019
- Primary completion
- Sep 30, 2026
- Completion
- Sep 30, 2027
- Last update posted
- Aug 5, 2024
2019 – 2027
United States locations
- U.S. sites
- 55
- U.S. states
- 28
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Arizona Kidney Disease & Hypertension Centers | Phoenix | Arizona | 85016 | — |
| Arizona Kidney Disease & Hypertension Centers | Scottsdale | Arizona | 85258 | — |
| Arizona Kidney Disease and Hypertension Centers | Tucson | Arizona | 85712 | — |
| Arizona Kidney Disease & Hypertension Centers | Tucson | Arizona | 85718 | — |
| Banner University Medical Center | Tucson | Arizona | 85719 | — |
| University of California Davis Medical Center | Davis | California | 95616 | — |
| University of California, Irvine | Irvine | California | 92697 | — |
| Keck School of Medicine USC | Los Angeles | California | 90033 | — |
| The Regents of the University of California on behalf of its Los Angeles campus | Los Angeles | California | 90095 | — |
| Riverside Community Hospital | Riverside | California | 92501 | — |
| California Institute of Renal Research | San Diego | California | 92123 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Yale University, School of Medicine | New Haven | Connecticut | 06520 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20057 | — |
| University of Florida | Gainesville | Florida | 32611 | — |
| Florida Health Sciences Center | Tampa | Florida | 33606 | — |
| Cleveland Clinic Florida (Weston) | Weston | Florida | 33331 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| The University of Kansas Medical Center Research Institute | Kansas City | Kansas | 66160 | — |
| University of Maryland | Baltimore | Maryland | 21201 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Lahey Hospital and Medical Center | Burlington | Massachusetts | 01805 | — |
| Renal Transplant Associates of New England | Springfield | Massachusetts | 01107 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Harper University Hospital, Detroit Medical Center, Wayne State University | Detroit | Michigan | 48201 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| St. Louis University | St Louis | Missouri | 63103 | — |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | 63110 | — |
| University of Nebraska | Omaha | Nebraska | 68198 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| Northwell Health, Inc | Manhasset | New York | 11030 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| The Research Institute at Westchester Medical Center | Valhalla | New York | 10595 | — |
| East Carolina University | Greenville | North Carolina | 27858 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| The University of Toledo | Toledo | Ohio | 43606 | — |
| Legacy Research | Portland | Oregon | 97232 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Kidney Care Specialists | Bethlehem | Pennsylvania | 18017 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Einstein Medical Center | Philadelphia | Pennsylvania | 19141 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Vanderbilt University | Nashville | Tennessee | 37235 | — |
| UT Southwestern | Dallas | Texas | 75390 | — |
| Baylor Scott and White Research Institute | Temple | Texas | 76508 | — |
| IHC Health Services, Inc | Salt Lake City | Utah | 84111 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04091984, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 5, 2024 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04091984 live on ClinicalTrials.gov.