A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study
Public ClinicalTrials.gov record NCT04103892. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Two-Part Study of CLE-100 as an Adjunct Therapy in Subjects With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The clinical trial is a Phase 2, double-blind, randomized, placebo controlled study in Major Depressive Disorder (MDD) participants currently treated with antidepressant therapy. The objective of the study is to assess CLE-100 for the treatment of MDD in participants currently treated with standard antidepressant therapy.
Study identification
- NCT ID
- NCT04103892
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 146 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 5, 2019 (Actual)
- Primary completion
- Sep 21, 2022 (Actual)
- Completion
- Oct 5, 2022 (Actual)
- Last update posted
- Oct 14, 2025
2019 – 2022
United States locations
- U.S. sites
- 45
- U.S. states
- 19
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Site 126 | Bentonville | Arkansas | 72712 | — |
| Clinical Site 120 | Little Rock | Arkansas | 72209 | — |
| Clinical Site 129 | Little Rock | Arkansas | 72209 | — |
| Clinical Site 141 | Anaheim | California | 92805 | — |
| Clinical Site 115 | Bellflower | California | 90706 | — |
| Clinical Site 132 | Lafayette | California | 94549 | — |
| Clinical Site 117 | Oakland | California | 94607 | — |
| Clinical Site 113 | Oceanside | California | 92056 | — |
| Clinical Site 123 | Riverside | California | 92506 | — |
| Clinical Site 124 | Santa Ana | California | 92705 | — |
| Clinical Site 142 | Santa Rosa | California | 95401 | — |
| Clinical Site 112 | Torrance | California | 90502 | — |
| Clinical Site 145 | Denver | Colorado | 80209 | — |
| Clinical Site 107 | Hialeah | Florida | 33016 | — |
| Clinical Site 116 | Miami | Florida | 33145 | — |
| Clinical Site 108 | Miami Gardens | Florida | 33014 | — |
| Clinical Site 105 | Orlando | Florida | 32803 | — |
| Clinical Site 137 | Orlando | Florida | 32807 | — |
| Clinical Site 140 | Atlanta | Georgia | 30338 | — |
| Clinical Site 104 | Decatur | Georgia | 30030 | — |
| Clinical Site 122 | Marietta | Georgia | 30060 | — |
| Clinical Site 131 | Baltimore | Maryland | 21208 | — |
| Clinical Site 136 | Rockville | Maryland | 20877 | — |
| Clinical Site 103 | Boston | Massachusetts | 02114 | — |
| Clinical Site 121 | Boston | Massachusetts | 02131 | — |
| Clinical Site 151 | Dearborn Heights | Michigan | 48034 | — |
| Clinical Site 139 | St Louis | Missouri | 63128 | — |
| Clinical Site 125 | Lincoln | Nebraska | 68526 | — |
| Clinical Site 110 | Las Vegas | Nevada | 89102 | — |
| Clinical Site 101 | Marlton | New Jersey | 08053 | — |
| Clinical Site 148 | Toms River | New Jersey | 08755 | — |
| Clinical Site 128 | New York | New York | 10036 | — |
| Clinical Site 102 | Staten Island | New York | 10312 | — |
| Clinical Site 111 | Hickory | North Carolina | 28601 | — |
| Clinical Site 143 | Raleigh | North Carolina | 27609 | — |
| Clinical Site 138 | Middleburg Heights | Ohio | 44130 | — |
| Clinical Site 127 | North Canton | Ohio | 44720 | — |
| Clinical Site 106 | Media | Pennsylvania | 19063 | — |
| Clinical Site 118 | Philadelphia | Pennsylvania | 19104 | — |
| Clinical Site 114 | Fort Worth | Texas | 76104 | — |
| Clinical Site 109 | Houston | Texas | 77030 | — |
| Clinical Site 149 | Missouri City | Texas | 88459 | — |
| Clinical Site 144 | Plano | Texas | 75093 | — |
| Clinical Site 147 | Draper | Utah | 84020 | — |
| Clinical Site 135 | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04103892, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2025 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04103892 live on ClinicalTrials.gov.