ClinicalTrials.gov record
Single Fraction Stereotactic Radiosurgery or Three to Five Fraction Stereotactic Radiosurgery in Treating Patients With Brain Metastasis That Has Been Removed by Surgery
ClinicalTrials.gov ID: NCT04114981
Public ClinicalTrials.gov record NCT04114981. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase III Trial of Post-Surgical Single Fraction Stereotactic Radiosurgery (SRS) Compared With Fractionated SRS (FSRS) for Resected Metastatic Brain Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase III trial studies how well single fraction stereotactic radiosurgery works compared with fractionated stereotactic radiosurgery in treating patients with cancer that has spread to the brain from other parts of the body (brain metastases) and has been removed by surgery (resected). Single fraction stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Fractionated stereotactic radiosurgery delivers multiple, smaller doses of radiation therapy over time. This study may help doctors find out if fractionated stereotactic radiosurgery is better or worse than the usual approach with single fraction stereotactic radiosurgery.
Study identification
- NCT ID
- NCT04114981
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 242 participants
Conditions and interventions
Conditions
Interventions
- Single Fraction Stereotactic Radiosurgery Radiation
- Fractionated Stereotactic Radiosurgery Radiation
- Quality-of-Life Assessment Procedure
- Questionnaire Administration Other
Radiation · Procedure · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 19, 2019 (Actual)
- Primary completion
- Dec 14, 2025 (Actual)
- Completion
- Sep 2028 (Estimated)
- Last update posted
- Sep 17, 2026
2019 – 2028
United States locations
- U.S. sites
- 223
- U.S. states
- 40
- U.S. cities
- 183
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Anchorage Radiation Therapy Center | Anchorage | Alaska | 99504 | — |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| Banner Thunderbird Medical Center | Glandale | Arizona | 85306 | — |
| Banner-University Medical Center Phoenix | Phoenix | Arizona | 85006 | — |
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | — |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| Los Angeles County-USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Epic Care Cyberknife Center | Walnut Creek | California | 94597 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| UCHealth Memorial Hospital Central | Colorado Springs | Colorado | 80909 | — |
| Yale University | New Haven | Connecticut | 06520 | — |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | — |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | — |
| Boca Raton Regional Hospital | Boca Raton | Florida | 33486 | — |
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables | Florida | 33146 | — |
| UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach | Florida | 33442 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224-9980 | — |
| University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Saint Joseph's Hospital/Children's Hospital-Tampa | Tampa | Florida | 33607 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Emory University Hospital Midtown | Atlanta | Georgia | 30308 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Emory Saint Joseph's Hospital | Atlanta | Georgia | 30342 | — |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | — |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | — |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | — |
| Walter Knox Memorial Hospital | Emmett | Idaho | 83617 | — |
| Idaho Urologic Institute-Meridian | Meridian | Idaho | 83642 | — |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | — |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | — |
| Kootenai Cancer Clinic | Sandpoint | Idaho | 83864 | — |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | — |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | — |
| Memorial Hospital of Carbondale | Carbondale | Illinois | 62902 | — |
| SIH Cancer Institute | Carterville | Illinois | 62918 | — |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | — |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | — |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | — |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | — |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | — |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | — |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | — |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | — |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | — |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | — |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | — |
| Good Samaritan Regional Health Center | Mount Vernon | Illinois | 62864 | — |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | — |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | — |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | — |
| OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center | Pekin | Illinois | 61554 | — |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | — |
| OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria | Illinois | 61615 | — |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | — |
| OSF Saint Francis Medical Center | Peoria | Illinois | 61637 | — |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | — |
| Valley Radiation Oncology | Peru | Illinois | 61354 | — |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Springfield Clinic | Springfield | Illinois | 62702 | — |
| Memorial Medical Center | Springfield | Illinois | 62781 | — |
| Southwest Illinois Health Services LLP | Swansea | Illinois | 62226 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | — |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | — |
| University of Iowa/Holden Comprehensive Cancer Center | Iowa City | Iowa | 52242 | — |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | — |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | — |
| University of Kansas Cancer Center | Kansas City | Kansas | 66160 | — |
| University of Kansas Cancer Center-Overland Park | Overland Park | Kansas | 66210 | — |
| University of Kansas Hospital-Indian Creek Campus | Overland Park | Kansas | 66211 | — |
| University of Kansas Hospital-Westwood Cancer Center | Westwood | Kansas | 66205 | — |
| University of Kentucky/Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | — |
| Woman's Hospital | Baton Rouge | Louisiana | 70817 | — |
| Maine Medical Center- Scarborough Campus | Scarborough | Maine | 04074 | — |
| MedStar Franklin Square Medical Center/Weinberg Cancer Institute | Baltimore | Maryland | 21237 | — |
| Saint Joseph Mercy Hospital | Ann Arbor | Michigan | 48106 | — |
| University of Michigan Comprehensive Cancer Center | Ann Arbor | Michigan | 48109 | — |
| McLaren Cancer Institute-Bay City | Bay City | Michigan | 48706 | — |
| Saint Joseph Mercy Brighton | Brighton | Michigan | 48114 | — |
| Saint Joseph Mercy Canton | Canton | Michigan | 48188 | — |
| Saint Joseph Mercy Chelsea | Chelsea | Michigan | 48118 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| McLaren Cancer Institute-Flint | Flint | Michigan | 48532 | — |
| Spectrum Health at Butterworth Campus | Grand Rapids | Michigan | 49503 | — |
| Karmanos Cancer Institute at McLaren Greater Lansing | Lansing | Michigan | 48910 | — |
| Trinity Health Saint Mary Mercy Livonia Hospital | Livonia | Michigan | 48154 | — |
| McLaren Cancer Institute-Macomb | Mount Clemens | Michigan | 48043 | — |
| Ascension Providence Hospitals - Novi | Novi | Michigan | 48374 | — |
| McLaren Cancer Institute-Northern Michigan | Petoskey | Michigan | 49770 | — |
| McLaren-Port Huron | Port Huron | Michigan | 48060 | — |
| Ascension Saint Mary's Hospital | Saginaw | Michigan | 48601 | — |
| Sanford Joe Lueken Cancer Center | Bemidji | Minnesota | 56601 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Cambridge Medical Center | Cambridge | Minnesota | 55008 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Miller-Dwan Hospital | Duluth | Minnesota | 55805 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | — |
| Monticello Cancer Center | Monticello | Minnesota | 55362 | — |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | — |
| Fairview Northland Medical Center | Princeton | Minnesota | 55371 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud | Minnesota | 56303 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Fairview Lakes Medical Center | Wyoming | Minnesota | 55092 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Saint Louis Cancer and Breast Institute-Ballwin | Ballwin | Missouri | 63011 | — |
| Parkland Health Center-Bonne Terre | Bonne Terre | Missouri | 63628 | — |
| Cox Cancer Center Branson | Branson | Missouri | 65616 | — |
| Saint Francis Medical Center | Cape Girardeau | Missouri | 63703 | — |
| Southeast Cancer Center | Cape Girardeau | Missouri | 63703 | — |
| Parkland Health Center - Farmington | Farmington | Missouri | 63640 | — |
| Capital Region Southwest Campus | Jefferson City | Missouri | 65109 | — |
| Freeman Health System | Joplin | Missouri | 64804 | — |
| Mercy Hospital Joplin | Joplin | Missouri | 64804 | — |
| University of Kansas Cancer Center - Lee's Summit | Lee's Summit | Missouri | 64064 | — |
| University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City | Missouri | 64116 | — |
| Delbert Day Cancer Institute at PCRMC | Rolla | Missouri | 65401 | — |
| Mercy Clinic-Rolla-Cancer and Hematology | Rolla | Missouri | 65401 | — |
| Heartland Regional Medical Center | Saint Joseph | Missouri | 64506 | — |
| Sainte Genevieve County Memorial Hospital | Sainte Genevieve | Missouri | 63670 | — |
| Mercy Hospital Springfield | Springfield | Missouri | 65804 | — |
| CoxHealth South Hospital | Springfield | Missouri | 65807 | — |
| Saint Louis Cancer and Breast Institute-South City | St Louis | Missouri | 63109 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Mercy Hospital South | St Louis | Missouri | 63128 | — |
| Missouri Baptist Medical Center | St Louis | Missouri | 63131 | — |
| Mercy Hospital Saint Louis | St Louis | Missouri | 63141 | — |
| Missouri Baptist Sullivan Hospital | Sullivan | Missouri | 63080 | — |
| Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills | Missouri | 63127 | — |
| Mercy Hospital Washington | Washington | Missouri | 63090 | — |
| Community Hospital of Anaconda | Anaconda | Montana | 59711 | — |
| Billings Clinic Cancer Center | Billings | Montana | 59101 | — |
| Bozeman Deaconess Hospital | Bozeman | Montana | 59715 | — |
| Benefis Healthcare- Sletten Cancer Institute | Great Falls | Montana | 59405 | — |
| Great Falls Clinic | Great Falls | Montana | 59405 | — |
| Kalispell Regional Medical Center | Kalispell | Montana | 59901 | — |
| Community Medical Hospital | Missoula | Montana | 59804 | — |
| Saint Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Community Medical Center | Toms River | New Jersey | 08755 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87102 | — |
| Glens Falls Hospital | Glens Falls | New York | 12801 | — |
| Mount Sinai Chelsea | New York | New York | 10011 | — |
| Mount Sinai West | New York | New York | 10019 | — |
| Mount Sinai Hospital | New York | New York | 10029 | — |
| NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Upstate Cancer Center Radiation Oncology at Oneida | Oneida | New York | 13421 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Stony Brook University Medical Center | Stony Brook | New York | 11794 | — |
| State University of New York Upstate Medical University | Syracuse | New York | 13210 | — |
| Novant Health Presbyterian Medical Center | Charlotte | North Carolina | 28204 | — |
| Novant Health Forsyth Medical Center | Winston-Salem | North Carolina | 27103 | — |
| Sanford Bismarck Medical Center | Bismarck | North Dakota | 58501 | — |
| Sanford Roger Maris Cancer Center | Fargo | North Dakota | 58122 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Mercy Hospital Oklahoma City | Oklahoma City | Oklahoma | 73120 | — |
| Saint Alphonsus Medical Center-Baker City | Baker City | Oregon | 97814 | — |
| Saint Alphonsus Medical Center-Ontario | Ontario | Oregon | 97914 | — |
| Legacy Good Samaritan Hospital and Medical Center | Portland | Oregon | 97210 | — |
| Northeast Radiation Oncology Center | Dunmore | Pennsylvania | 18512 | — |
| Fox Chase Cancer Center Buckingham | Furlong | Pennsylvania | 18925 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Guthrie Medical Group PC-Robert Packer Hospital | Sayre | Pennsylvania | 18840 | — |
| Saint Francis Cancer Center | Greenville | South Carolina | 29607 | — |
| Gibbs Cancer Center-Pelham | Greer | South Carolina | 29651 | — |
| Lexington Medical Center | West Columbia | South Carolina | 29169 | — |
| Sanford USD Medical Center - Sioux Falls | Sioux Falls | South Dakota | 57117-5134 | — |
| Baptist Memorial Hospital and Cancer Center-Memphis | Memphis | Tennessee | 38120 | — |
| UT Southwestern/Simmons Cancer Center-Dallas | Dallas | Texas | 75390 | — |
| Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center | Houston | Texas | 77030 | — |
| M D Anderson Cancer Center | Houston | Texas | 77030 | — |
| Memorial Hermann Texas Medical Center | Houston | Texas | 77030 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Virginia Commonwealth University/Massey Cancer Center | Richmond | Virginia | 23298 | — |
| Northwest Wisconsin Cancer Center | Ashland | Wisconsin | 54806 | — |
| Ascension Southeast Wisconsin Hospital - Elmbrook Campus | Brookfield | Wisconsin | 53045 | — |
| Ascension Saint Francis - Reiman Cancer Center | Franklin | Wisconsin | 53132 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Ascension Columbia Saint Mary's Hospital - Milwaukee | Milwaukee | Wisconsin | 53211 | — |
| Aurora Saint Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
| Ascension All Saints Hospital | Racine | Wisconsin | 53405 | — |
| UW Cancer Center at ProHealth Care | Waukesha | Wisconsin | 53188 | — |
| Aspirus Regional Cancer Center | Wausau | Wisconsin | 54401 | — |
| Billings Clinic-Cody | Cody | Wyoming | 82414 | — |
| Welch Cancer Center | Sheridan | Wyoming | 82801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 9 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04114981, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 17, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04114981 live on ClinicalTrials.gov.