Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

ClinicalTrials.gov ID: NCT04131829

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.

Study identification

NCT ID: NCT04131829
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Yale University; Other
Enrollment: 100 participants

Conditions and interventions

Conditions

Obsessive-Compulsive Disorder

Interventions

Fluoxetine - immediate treatment Drug
Fluoxetine - delayed treatment Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Accepts healthy volunteers

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 14, 2019 (Actual)
Primary completion: Sep 2027 (Estimated)
Completion: Sep 2027 (Estimated)
Last update posted: Sep 22, 2026

2019 – 2027

United States locations

U.S. sites: 1
U.S. states: 1
U.S. cities: 1

Facility	City	State	ZIP	Site status
Yale OCD Research Clinic - CMHC/CNRU, 34 Park ST	New Haven	Connecticut	06519	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04131829, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 22, 2026 · Synced Nov 15, 2026