ClinicalTrials.gov record
CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
ClinicalTrials.gov ID: NCT04136171
Public ClinicalTrials.gov record NCT04136171. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Global, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ION-682884 in Patients With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)
Study identification
- NCT ID
- NCT04136171
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Ionis Pharmaceuticals, Inc.
- Industry
- Enrollment
- 1,438 participants
Conditions and interventions
Interventions
- Eplontersen Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 12, 2020
- Primary completion
- Mar 31, 2026
- Completion
- Jul 31, 2026
- Last update posted
- Aug 7, 2025
2020 – 2026
United States locations
- U.S. sites
- 51
- U.S. states
- 27
- U.S. cities
- 42
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic - Arizona | Phoenix | Arizona | 85054 | — |
| Altman Clinical and Translational Research Institute Center for Clinical Research | La Jolla | California | 92037 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California, San Francisco (UCSF) - Medical Center | San Francisco | California | 94143 | — |
| Stanford Hospital | Stanford | California | 94305 | — |
| University of Colorado Hospital - Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| The George Washington Medical Faculty Associates - Foggy Bottom North Pavilion | Washington D.C. | District of Columbia | 20037 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Emory Heart and Vascular Center - Emory Clifton Campus | Atlanta | Georgia | 30322 | — |
| Piedmont Heart of Fayetteville | Fayetteville | Georgia | 30214 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Indiana University Health | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Louisiana State University Health Sciences Center | New Orleans | Louisiana | 70112 | — |
| Tulane University Heart and Vascular Institute | New Orleans | Louisiana | 70112 | — |
| Ochsner Health System | New Orleans | Louisiana | 70121 | — |
| University of Maryland Medical Center | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Boston University School of Medicine | Boston | Massachusetts | 02118 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Minneapolis Heart Institute | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| New York University Langone Cardiology Associates | New York | New York | 10016 | — |
| Columbia University Irving Medical Center | New York | New York | 10034 | — |
| Weill Cornell Medicine Cardiology | New York | New York | 10065 | — |
| Laurelton Heart Specialists | Rosedale | New York | 11422 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Carl and Edyth Lindner Research Center at The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | — |
| The Ohio State University College of Medicine | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Lancaster General Hospital | Lancaster | Pennsylvania | 17602 | — |
| Penn Presbyterian Medical Center | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh Medical School | Pittsburgh | Pennsylvania | 15261 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84112 | — |
| Virginia Commonwealth University (VCU) | Richmond | Virginia | 23298 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| University of Wisconsin - Madison | Madison | Wisconsin | 53792 | — |
| Froedtert & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 91 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04136171, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 7, 2025 · Synced Jul 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04136171 live on ClinicalTrials.gov.