An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)
Public ClinicalTrials.gov record NCT04145531. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Open-Label, Multicenter Study of Recombinant Crisantaspase Produced in Pseudomonas Fluorescens (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL) Following Hypersensitivity to E. Coli-derived Asparaginases
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an open-label, multicenter, dose confirmation, and PK study of JZP-458 in patients (of any age) with ALL/LBL who are hypersensitive to E. coli-derived asparaginases (allergic reaction or silent inactivation). This study is designed to assess the tolerability and efficacy of JZP-458 (only in patients who develop hypersensitivity to an E. coli-derived asparaginase), as measured by asparaginase activity.
Study identification
- NCT ID
- NCT04145531
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 229 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 27, 2019 (Actual)
- Primary completion
- Jul 13, 2022 (Actual)
- Completion
- Jul 13, 2022 (Actual)
- Last update posted
- Nov 18, 2023
2019 – 2022
United States locations
- U.S. sites
- 67
- U.S. states
- 30
- U.S. cities
- 61
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Children's of Alabama | Birmingham | Alabama | 35233 | — |
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202 | — |
| Kaiser Permanente - Orange County - Anaheim Medical Center | Anaheim | California | 92806 | — |
| Kaiser Permanente - Downey Medical Center | Downey | California | 90242 | — |
| Kaiser Permanente - Fontana Medical Center | Fontana | California | 92335 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92350 | — |
| MemorialCare Miller Children's and Women's Hospital Long Beach | Long Beach | California | 90806 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Kaiser Permanente- Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Benioff Children's Hospital Oakland | Oakland | California | 94609 | — |
| Kaiser Permanente - Oakland Medical Center | Oakland | California | 94611 | — |
| Children's Hospital of Orange County Main Campus - Orange | Orange | California | 92868 | — |
| Kaiser Permanente - Roseville Medical Center | Roseville | California | 95661 | — |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Kaiser Permanente - San Diego Medical Center | San Diego | California | 92120 | — |
| University of California San Francisco Benioff Children's Hospital - Mission Bay | San Francisco | California | 94158 | — |
| Kaiser Permanente - Santa Clara Medical Center | Santa Clara | California | 95051 | — |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | — |
| Smilow Cancer Hospital - New Haven | New Haven | Connecticut | 06511 | — |
| Nemours Alfred I. Dupont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Children's National Health System | Washington D.C. | District of Columbia | 20010 | — |
| Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | 33908 | — |
| Memorial Medical Office Centre | Hollywood | Florida | 33021 | — |
| Nemours Children's Specialty Care Jacksonville | Jacksonville | Florida | 32207 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| Johns Hopkins All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Scottish Rite Hospital | Atlanta | Georgia | 30342 | — |
| Kapi'olani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Ann and Robert H. Lurie Children's Hospital of Chicago | Chicago | Illinois | 60611 | — |
| Norton Children's Hospital | Louisville | Kentucky | 40202 | — |
| Dana-Farber/Boston Children's Cancer and Blood Disorders Center | Boston | Massachusetts | 02215 | — |
| C.S. Mott Children's Hospital | Ann Arbor | Michigan | 48109 | — |
| Children's Minnesota | Minneapolis | Minnesota | 55404 | — |
| Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Washington University School of Medicine in Saint Louis | St Louis | Missouri | 63110 | — |
| Alliance for Childhood Diseases | Las Vegas | Nevada | 89135 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08903 | — |
| Cohen Children's Medical Center | New Hyde Park | New York | 11040 | — |
| NYU - Stephen D. Hassenfeld Children's Center for Cancer and Blood Disorders | New York | New York | 10016 | — |
| Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | — |
| Memorial Sloan-Kettering Cancer Center - New York | New York | New York | 10065 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| The Children's Hospital at Oklahoma University Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University | Portland | Oregon | 97201 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh Medical Center - Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15224 | — |
| Neurology Clinic, P.C | Cordova | Tennessee | 38018 | — |
| East Tennessee Children's Hospital | Knoxville | Tennessee | 37913 | — |
| St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Children's Blood and Cancer Center | Austin | Texas | 78723 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Texas Children's Hospital | Houston | Texas | 77030 | — |
| Methodist Hospital - San Antonio | San Antonio | Texas | 78229 | — |
| Primary Children's Hospital | Salt Lake City | Utah | 84113 | — |
| Inova Medical Group - Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Children's Hospital of The King's Daughters | Norfolk | Virginia | 23507 | — |
| Massey Cancer Center | Richmond | Virginia | 23220 | — |
| Seattle Children's Hospital | Seattle | Washington | 98105 | — |
| Providence Sacred Heart Medical Center | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04145531, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 18, 2023 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04145531 live on ClinicalTrials.gov.