Descartes-08 CAR-T Cells in Generalized Myasthenia Gravis (MG)
Public ClinicalTrials.gov record NCT04146051. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Autologous T-Cells Expressing A Chimeric Antigen Receptor Directed To B-Cell Maturation Antigen (BCMA) In Patients With Generalized Myasthenia Gravis (MG)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IIb study to evaluate the safety and preliminary efficacy of Descartes-08 CAR T-cells in patients with Generalized Myasthenia Gravis
Study identification
- NCT ID
- NCT04146051
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 30 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 4, 2019 (Actual)
- Primary completion
- Jan 5, 2026 (Actual)
- Completion
- Sep 30, 2026 (Estimated)
- Last update posted
- Aug 14, 2026
2019 – 2026
United States locations
- U.S. sites
- 14
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Profound Research | Carlsbad | California | 92011 | — |
| University of California Irvine | Irvine | California | 92697 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| SFM Clinical Research, LLC | Boca Raton | Florida | 33487 | — |
| Neurology Associates, P.A. | Orlando | Florida | 32751 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| University of Augusta | Augusta | Georgia | 30912 | — |
| University of Kansas Medical Center Research Institute | Kansas City | Kansas | 66160 | — |
| Dent Neurologic Institute | Amherst | New York | 14226 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15212 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04146051, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 14, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04146051 live on ClinicalTrials.gov.