ClinicalTrials.gov record
The ENCIRCLE Trial
ClinicalTrials.gov ID: NCT04153292
Public ClinicalTrials.gov record NCT04153292. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:26 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
SAPIEN M3 System Transcatheter Mitral Valve Replacement Via Transseptal Access
Study identification
- NCT ID
- NCT04153292
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- Edwards Lifesciences
- Industry
- Enrollment
- 900 participants
Conditions and interventions
Conditions
Interventions
- SAPIEN M3 valve and dock Device
Device
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 11, 2020
- Primary completion
- Feb 27, 2027
- Completion
- Feb 27, 2031
- Last update posted
- Feb 24, 2026
2020 – 2031
United States locations
- U.S. sites
- 56
- U.S. states
- 29
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Heart Center Hospital | Huntsville | Alabama | 35801 | Active, not recruiting |
| Banner University Medical Center | Phoenix | Arizona | 85006 | Active, not recruiting |
| Saint Josephs Hospital Medical Center Dignity Health | Phoenix | Arizona | 85013 | Active, not recruiting |
| TMC Healthcare | Tucson | Arizona | 85712 | Withdrawn |
| Scripps Health | La Jolla | California | 92037 | Active, not recruiting |
| Good Samaritan Hospital | Los Angeles | California | 90017 | Active, not recruiting |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Active, not recruiting |
| Kaiser Sunset LA | Los Angeles | California | 90071 | Active, not recruiting |
| Saint Joseph Hospital | Orange | California | 92868 | Withdrawn |
| California Pacific Medical Center | San Francisco | California | 94109 | Active, not recruiting |
| UC Health Northern Colorado (Medical Center of the Rockies) | Loveland | Colorado | 80538 | Active, not recruiting |
| Delray Medical Center | Delray Beach | Florida | 33484 | Withdrawn |
| Cardiac & Vascular Institute Foundation | Gainesville | Florida | 32605 | Active, not recruiting |
| Ascension St. Vincent's Hospital | Jacksonville | Florida | 32204 | Active, not recruiting |
| Naples Community Hospital | Naples | Florida | 34102 | Active, not recruiting |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | Active, not recruiting |
| Emory University | Atlanta | Georgia | 30308 | Active, not recruiting |
| Piedmont Healthcare | Atlanta | Georgia | 30309 | Active, not recruiting |
| Rush University Medical Center | Chicago | Illinois | 60612 | Withdrawn |
| Northshore University Health System | Glenview | Illinois | 60026 | Active, not recruiting |
| St. Vincent Heart Center of Indiana | Indianapolis | Indiana | 46290 | Withdrawn |
| University of Kansas | Kansas City | Kansas | 66160 | Active, not recruiting |
| Cardiovascular Research Institute of Kansas (CRIOK) | Wichita | Kansas | 67226 | Active, not recruiting |
| Our Lady of the Lake Regional Medical Center | Baton Rouge | Louisiana | 70808 | Active, not recruiting |
| Medstar Union Memorial Hospital | Baltimore | Maryland | 21218 | Active, not recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Active, not recruiting |
| Brigham & Women's | Boston | Massachusetts | 02115 | Withdrawn |
| Henry Ford | Detroit | Michigan | 48202 | Active, not recruiting |
| Minneapolis Heart | Minneapolis | Minnesota | 55407 | Withdrawn |
| Mayo Clinic | Rochester | Minnesota | 55905 | Active, not recruiting |
| CentraCare | Saint Cloud | Minnesota | 56303 | Active, not recruiting |
| Saint Luke's Kansas City | Kansas City | Missouri | 64111 | Active, not recruiting |
| St. Patrick Hospital | Missoula | Montana | 59802 | Withdrawn |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Active, not recruiting |
| Morristown Medical Center | Morristown | New Jersey | 07962 | Withdrawn |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Active, not recruiting |
| University of Buffalo | Buffalo | New York | 14203 | Active, not recruiting |
| Weill Cornell Medicine | New York | New York | 10007 | Active, not recruiting |
| Carolinas Medical Center | Charlotte | North Carolina | 28203 | Withdrawn |
| Novant Health and Vascular Institute | Charlotte | North Carolina | 28204 | Active, not recruiting |
| The Christ Hospital | Cincinnati | Ohio | 45219 | Active, not recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44122 | Active, not recruiting |
| Mount Carmel East Hospital | Columbus | Ohio | 43123 | Active, not recruiting |
| Oklahoma Heart Hospital | Oklahoma City | Oklahoma | 73120 | Active, not recruiting |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | Active, not recruiting |
| UPMC Heart and Vascular Institute | Mechanicsburg | Pennsylvania | 17050 | Active, not recruiting |
| Alleghany General Hospital | Pittsburgh | Pennsylvania | 15212 | Withdrawn |
| Saint Thomas Health | Nashville | Tennessee | 37205 | Active, not recruiting |
| Austin Heart | Austin | Texas | 78705 | Active, not recruiting |
| HCA Houston Healthcare Medical (SCRI) | Houston | Texas | 77004 | Active, not recruiting |
| UT Memorial Hermann | Houston | Texas | 77030 | Active, not recruiting |
| Intermountain Medical Center | Murray | Utah | 84107 | Active, not recruiting |
| Sentara Norfolk | Norfolk | Virginia | 23507 | Active, not recruiting |
| Carilion Roanoke Memorial Hospital | Roanoke | Virginia | 24014 | Active, not recruiting |
| University of Washington Seattle | Seattle | Washington | 98195 | Active, not recruiting |
| University of Wisconsin | Madison | Wisconsin | 53792-3248 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 12 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04153292, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 24, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04153292 live on ClinicalTrials.gov.