A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure
Public ClinicalTrials.gov record NCT04157751. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicentre, Randomised, Double-blind, 90-day Superiority Trial to Evaluate the Effect on Clinical Benefit, Safety and Tolerability of Once Daily Oral EMPagliflozin 10 mg Compared to Placebo, Initiated in Patients Hospitalised for acUte Heart faiLure (de Novo or Decompensated Chronic HF) Who Have Been StabilisEd (EMPULSE)
Study identification
- NCT ID
- NCT04157751
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Boehringer Ingelheim
- Industry
- Enrollment
- 530 participants
Conditions and interventions
Conditions
Interventions
- Empagliflozin Drug
- Placebo to Empagliflozin Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 17, 2020
- Primary completion
- May 27, 2021
- Completion
- Jun 1, 2021
- Last update posted
- Jul 18, 2022
2020 – 2021
United States locations
- U.S. sites
- 30
- U.S. states
- 18
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Irvine | Orange | California | 92865 | — |
| The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| Cardiology Associates Research Co. | Daytona Beach | Florida | 32117 | — |
| University of Florida Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Grady Memorial Hospital | Atlanta | Georgia | 30303 | — |
| Methodist Medical Center | Peoria | Illinois | 61603 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| University Of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| Saint Luke's Hospital of Kansas City | Kansas City | Missouri | 64111 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Cardiovascular Associates of the Delaware Valley | Elmer | New Jersey | 08318 | — |
| Jefferson Washington Township Hospital | Washington Township | New Jersey | 08080 | — |
| Erie County Medical Center | Buffalo | New York | 14215 | — |
| The DeMatteis Center for Cardiac Research and Education | Greenvale | New York | 11548 | — |
| Stony Brook Medicine | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27599 | — |
| North Carolina Heart and Vascular | Raleigh | North Carolina | 27607 | — |
| University of Oklahoma | Oklahoma City | Oklahoma | 73104 | — |
| South Oklahoma Heart Research Group | Oklahoma City | Oklahoma | 73135 | — |
| Ralph H. Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Pharmatex Research | Amarillo | Texas | 79109 | — |
| Center for Advanced Cardiac Care - Heart Failure Clinic | Plano | Texas | 75093 | — |
| Inova Fairfax Medical Campus | Falls Church | Virginia | 22042 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 88 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04157751, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 18, 2022 · Synced Jul 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04157751 live on ClinicalTrials.gov.