Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

ClinicalTrials.gov ID: NCT04159103

Public ClinicalTrials.gov record NCT04159103. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced Jul 21, 2026, 10:13 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Global, Phase 1/2, Open-Label, Dose Optimization Study to Evaluate the Safety, Pharmacodynamics, and Pharmacokinetics of mRNA-3927 in Participants With Propionic Acidemia

Study identification

NCT ID: NCT04159103
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: ModernaTX, Inc.; Industry
Enrollment: 77 participants

Conditions and interventions

Conditions

Propionic Acidemia

Interventions

mRNA-3927 Biological

Biological

Eligibility (public fields only)

Age range: Not listed
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 14, 2021
Primary completion: Aug 30, 2027
Completion: Aug 30, 2027
Last update posted: Jan 21, 2026

2021 – 2027

United States locations

U.S. sites: 15
U.S. states: 11
U.S. cities: 14

Facility	City	State	ZIP	Site status
UCSD Altman Clinical and Transalational Research Institute Building	Los Angeles	California	90027	Not yet recruiting
Ronald Reagan UCLA Medical Center	Los Angeles	California	90095	Recruiting
Lucile Packard Children's Hospital Stanford	Stanford	California	94304	Recruiting
Nicklaus Children's Hospital	Miami	Florida	33155	Not yet recruiting
University of South Florida - 12901 Bruce B Downs	Tampa	Florida	33606-3603	Not yet recruiting
Ann and Robert H Lurie Childrens Hospital of Chicago	Chicago	Illinois	60611	Recruiting
Johns Hopkins Hospital, Adult Outpatient Clinical Research Unit	Baltimore	Maryland	21287	Completed
Boston Children's Hospital	Boston	Massachusetts	02115	Completed
University of Michigan Hospitals	Ann Arbor	Michigan	48109	Recruiting
Icahn School of Medicine at Mount Sinai - Clinical Research Unit	New York	New York	10029	Recruiting
Duke University Medical System (Duke Health)	Durham	North Carolina	27710	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Completed
University Hospitals Cleveland Medical Center - 11100 Euclid Ave	Cleveland	Ohio	44106-2624	Active, not recruiting
Children's Hospital of Philadelphia (CHOP)	Philadelphia	Pennsylvania	19104	Recruiting
Texas Children's Hospital	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 20 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04159103, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 21, 2026 · Synced Jul 21, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04159103 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →