Trial-Ready Cohort-Down Syndrome (TRC-DS)

ClinicalTrials.gov ID: NCT04165109

Public ClinicalTrials.gov record NCT04165109. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 17, 2026, 6:45 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Alzheimer's Clinical Trial Consortium for Down Syndrome (ACTC-DS) Trial-Ready Cohort - Down Syndrome (TRC-DS)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the Trial-Ready Cohort - Down Syndrome (TRC-DS) is to enroll 120 healthy adults with Down syndrome (DS), between the ages of 25-55, into a trial ready cohort (TRC), and up to 550 participants in total including co-enrolled in the Alzheimer Biomarkers Consortium - Down Syndrome (ABC-DS) study. Participants enrolled in the TRC-DS will undergo longitudinal cognitive and clinical assessment, genetic and biomarker testing, as well as imaging and biospecimen collection. Using these outcome measures, researchers will analyze the relationships between cognitive measures and biomarkers of Alzheimer's disease (AD) to identify endpoints for AD clinical trials in DS that best reflect disease progression. To learn more about the study and participating sites, visit our study website at: https://www.trcds.org/. TRC-DS is collaborating with the Alzheimer's Disease Biomarker Consortium-Down Syndrome (ABC-DS) to allow study participants to be concurrently enrolled in both ABC-DS and TRC-DS, referred to as "co-enrollment". ABC-DS is a longitudinal, observational research study that is overseen at University of Pittsburgh Coordinating Center. ABC-DS participants who express interest in potentially joining a clinical trial in the future and who meet TRC-DS eligibility criteria, may choose to co-enroll in TRC-DS at an ABC-DS Site. Co-enrolled participants will adhere to the ABC-DS protocol and schedule of activities, but agree to share their data with the TRC-DS team and to receive invitations for future participation in clinical trials. Fore more information on ABC-DS please visit https://www.nia.nih.gov/research/abc-ds or http://abcds.pitt.edu/.

Study identification

NCT ID: NCT04165109
Recruitment status: Recruiting
Study type: Observational
Phase: Not listed
Lead sponsor: University of Southern California; Other
Enrollment: 550 participants

Conditions and interventions

Conditions

Interventions

Not listed

Eligibility (public fields only)

Age range: 25 Years to 55 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 6, 2021
Primary completion: Dec 30, 2027
Completion: Dec 30, 2027
Last update posted: May 17, 2026

2021 – 2027

United States locations

U.S. sites: 18
U.S. states: 17
U.S. cities: 18

Facility	City	State	ZIP	Site status
Barrow Neurological Institute	Phoenix	Arizona	85013	Recruiting
University of California, Irvine School of Medicine, Co-Enrolling through ABC-DS Only	Orange	California	92868	Recruiting
Linda Crnic Institute for Down Syndrome, University of Colorado	Aurora	Colorado	80045	Recruiting
Advocate Medical Group Adult Down Syndrome Center	Park Ridge	Illinois	60068	Not yet recruiting
Indiana University	Indianapolis	Indiana	46202	Recruiting
University of Kansas Medical Center	Kansas City	Kansas	66160	Recruiting
University of Kentucky, Co-Enrolling through ABC-DS Only	Lexington	Kentucky	40504	Recruiting
Massachusetts General Hospital, Co-Enrolling through ABC-DS Only	Boston	Massachusetts	02114	Recruiting
Washington University, St. Louis	St Louis	Missouri	63108	Recruiting
Cleveland Clinic, Lou Ruvo Center for Brain Health, Las Vegas	Las Vegas	Nevada	89106	Not yet recruiting
New York State Institute for Basic Research in Developmental Disabilities (SIBRDD), Co-Enrolling through ABC-DS Only	Staten Island	New York	10314	Recruiting
Case Western Reserve University	Beachwood	Ohio	44122	Recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Not yet recruiting
Oregon Health & Science University	Portland	Oregon	97239	Not yet recruiting
University of Pittsburgh, Co-Enrolling through ABC-DS Only	Pittsburgh	Pennsylvania	15213	Recruiting
Vanderbilt University Medical Center Center for Cognitive Medicine	Nashville	Tennessee	37212	Recruiting
University of Texas Health San Antonio, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases	San Antonio	Texas	78229	Recruiting
University of Wisconsin - Madison, Waisman Center, Co-Enrolling through ABC-DS Only	Madison	Wisconsin	53705	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04165109, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 17, 2026 · Synced Sep 17, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04165109 live on ClinicalTrials.gov.

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