A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

ClinicalTrials.gov ID: NCT04166409

Public ClinicalTrials.gov record NCT04166409. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine Versus Selumetinib (NSC# 748727) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) Not Associated With BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1)

Study identification

NCT ID: NCT04166409
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 170 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Carboplatin Drug
Echocardiography Test Procedure
Magnetic Resonance Imaging Procedure
Questionnaire Administration Other
Selumetinib Sulfate Drug
Vincristine Sulfate Drug

Procedure · Drug · Other

Eligibility (public fields only)

Age range: 2 Years to 21 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 30, 2020
Primary completion: Dec 30, 2030
Completion: Dec 30, 2030
Last update posted: May 6, 2026

2020 – 2030

United States locations

U.S. sites: 124
U.S. states: 43
U.S. cities: 104

Facility	City	State	ZIP	Site status
Children's Hospital of Alabama	Birmingham	Alabama	35233	Recruiting
Banner Children's at Desert	Mesa	Arizona	85202	Recruiting
Phoenix Childrens Hospital	Phoenix	Arizona	85016	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202-3591	Recruiting
Loma Linda University Medical Center	Loma Linda	California	92354	Recruiting
Miller Children's and Women's Hospital Long Beach	Long Beach	California	90806	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
Mattel Children's Hospital UCLA	Los Angeles	California	90095	Recruiting
Kaiser Permanente-Oakland	Oakland	California	94611	Recruiting
Children's Hospital of Orange County	Orange	California	92868	Recruiting
Lucile Packard Children's Hospital Stanford University	Palo Alto	California	94304	Recruiting
Rady Children's Hospital - San Diego	San Diego	California	92123	Recruiting
UCSF Medical Center-Mission Bay	San Francisco	California	94158	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Connecticut Children's Medical Center	Hartford	Connecticut	06106	Recruiting
Yale University	New Haven	Connecticut	06520	Recruiting
Alfred I duPont Hospital for Children	Wilmington	Delaware	19803	Recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Recruiting
Golisano Children's Hospital of Southwest Florida	Fort Myers	Florida	33908	Recruiting
UF Health Cancer Institute - Gainesville	Gainesville	Florida	32610	Active, not recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	33021	Recruiting
Nemours Children's Clinic-Jacksonville	Jacksonville	Florida	32207	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Withdrawn
Nicklaus Children's Hospital	Miami	Florida	33155	Recruiting
AdventHealth Orlando	Orlando	Florida	32803	Recruiting
Arnold Palmer Hospital for Children	Orlando	Florida	32806	Recruiting
Nemours Children's Hospital	Orlando	Florida	32827	Recruiting
Nemours Children's Clinic - Pensacola	Pensacola	Florida	32504	Recruiting
Sacred Heart Hospital	Pensacola	Florida	32504	Suspended
Johns Hopkins All Children's Hospital	St. Petersburg	Florida	33701	Recruiting
Saint Joseph's Hospital/Children's Hospital-Tampa	Tampa	Florida	33607	Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital	Atlanta	Georgia	30329	Recruiting
Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	96826	Recruiting
Saint Luke's Cancer Institute - Boise	Boise	Idaho	83712	Recruiting
Lurie Children's Hospital-Chicago	Chicago	Illinois	60611	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Saint Jude Midwest Affiliate	Peoria	Illinois	61637	Recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Riley Hospital for Children	Indianapolis	Indiana	46202	Recruiting
Ascension Saint Vincent Indianapolis Hospital	Indianapolis	Indiana	46260	Recruiting
Blank Children's Hospital	Des Moines	Iowa	50309	Recruiting
University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	52242	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
Children's Hospital New Orleans	New Orleans	Louisiana	70118	Recruiting
Eastern Maine Medical Center	Bangor	Maine	04401	Recruiting
Maine Children's Cancer Program	Scarborough	Maine	04074	Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	21287	Recruiting
Walter Reed National Military Medical Center	Bethesda	Maryland	20889-5600	Recruiting
Massachusetts General Hospital Cancer Center	Boston	Massachusetts	02114	Active, not recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Active, not recruiting
C S Mott Children's Hospital	Ann Arbor	Michigan	48109	Recruiting
Children's Hospital of Michigan	Detroit	Michigan	48201	Recruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital	Grand Rapids	Michigan	49503	Recruiting
Corewell Health Children's	Royal Oak	Michigan	48073	Active, not recruiting
Children's Hospitals and Clinics of Minnesota - Minneapolis	Minneapolis	Minnesota	55404	Recruiting
University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Recruiting
Children's Mercy Hospitals and Clinics	Kansas City	Missouri	64108	Recruiting
Cardinal Glennon Children's Medical Center	St Louis	Missouri	63104	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Children's Hospital and Medical Center of Omaha	Omaha	Nebraska	68114	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Morristown Medical Center	Morristown	New Jersey	07960	Recruiting
Albany Medical Center	Albany	New York	12208	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Recruiting
NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
The Steven and Alexandra Cohen Children's Medical Center of New York	New Hyde Park	New York	11040	Recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Rochester	Rochester	New York	14642	Active, not recruiting
State University of New York Upstate Medical University	Syracuse	New York	13210	Recruiting
New York Medical College	Valhalla	New York	10595	Recruiting
UNC Lineberger Comprehensive Cancer Center	Chapel Hill	North Carolina	27599	Recruiting
Carolinas Medical Center/Levine Cancer Institute	Charlotte	North Carolina	28203	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
East Carolina University	Greenville	North Carolina	27834	Recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Recruiting
Sanford Broadway Medical Center	Fargo	North Dakota	58122	Recruiting
Children's Hospital Medical Center of Akron	Akron	Ohio	44308	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Rainbow Babies and Childrens Hospital	Cleveland	Ohio	44106	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
Dayton Children's Hospital	Dayton	Ohio	45404	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Geisinger Medical Center	Danville	Pennsylvania	17822	Recruiting
Penn State Children's Hospital	Hershey	Pennsylvania	17033	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Saint Christopher's Hospital for Children	Philadelphia	Pennsylvania	19134	Recruiting
Children's Hospital of Pittsburgh of UPMC	Pittsburgh	Pennsylvania	15224	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Prisma Health Richland Hospital	Columbia	South Carolina	29203	Recruiting
BI-LO Charities Children's Cancer Center	Greenville	South Carolina	29605	Recruiting
East Tennessee Childrens Hospital	Knoxville	Tennessee	37916	Recruiting
Saint Jude Children's Research Hospital	Memphis	Tennessee	38105	Recruiting
Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	37232	Recruiting
Dell Children's Medical Center of Central Texas	Austin	Texas	78723	Recruiting
UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	75390	Recruiting
El Paso Children's Hospital	El Paso	Texas	79905	Recruiting
Cook Children's Medical Center	Fort Worth	Texas	76104	Recruiting
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	77030	Recruiting
M D Anderson Cancer Center	Houston	Texas	77030	Recruiting
Covenant Children's Hospital	Lubbock	Texas	79410	Recruiting
UMC Cancer Center / UMC Health System	Lubbock	Texas	79415	Recruiting
Children's Hospital of San Antonio	San Antonio	Texas	78207	Recruiting
Methodist Children's Hospital of South Texas	San Antonio	Texas	78229	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
Primary Children's Hospital	Salt Lake City	Utah	84113	Recruiting
University of Vermont and State Agricultural College	Burlington	Vermont	05405	Recruiting
Children's Hospital of The King's Daughters	Norfolk	Virginia	23507	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Carilion Children's	Roanoke	Virginia	24014	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting
Providence Sacred Heart Medical Center and Children's Hospital	Spokane	Washington	99204	Recruiting
Mary Bridge Children's Hospital and Health Center	Tacoma	Washington	98405	Recruiting
Madigan Army Medical Center	Tacoma	Washington	98431	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting
Children's Hospital of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04166409, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04166409 live on ClinicalTrials.gov.

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