ClinicalTrials.gov record
A Study Evaluating the Efficacy and Safety of Oral Etrasimod in the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov ID: NCT04173273
Public ClinicalTrials.gov record NCT04173273. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-Blind, Parallel-Group Study to Assess the Efficacy and Safety of Oral Etrasimod as Induction and Maintenance Therapy for Moderately to Severely Active Crohn's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 2/3 study that comprises 5 substudies designed to evaluate the efficacy, safety, and tolerability of oral etrasimod as therapy in adult participants with moderately to severely active Crohn's disease (CD) who are refractory or intolerant to at least 1 of the current therapies for CD (ie, corticosteroids, immunosuppressants, or biologics). The overall duration of this study is up to 282 weeks, inclusive of the Screening Period, Treatment Period of up to 274 weeks (Induction, Extension or Maintenance, and Long-term Extension Periods), and the 4-Week Follow-Up Period for safety assessment.
Study identification
- NCT ID
- NCT04173273
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 379 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 6, 2020 (Actual)
- Primary completion
- Apr 23, 2025 (Actual)
- Completion
- Jun 9, 2025 (Actual)
- Last update posted
- Jul 1, 2026
2020 – 2025
United States locations
- U.S. sites
- 192
- U.S. states
- 20
- U.S. cities
- 65
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Center for Digestive Health (Endoscopy Location) | Dothan | Alabama | 36301 | — |
| Digestive Health Specialists | Dothan | Alabama | 36301 | — |
| Dothan Eyecare-Dr. Brent McKinley (OCT Location) | Dothan | Alabama | 36301 | — |
| Pulmonary Associates (PFT Location) | Dothan | Alabama | 36301 | — |
| Flowers Hospital (Imaging Location) | Dothan | Alabama | 36305 | — |
| Digestive Health Specialists (Satellite Clinic Location) | Mobile | Alabama | 36608 | — |
| Premier Medical Group East (Opthalmology & Optometry Facility) | Mobile | Alabama | 36608 | — |
| Pulmonary Associates (Chest X-Ray & PFT Facility) | Mobile | Alabama | 36608 | — |
| Surgicare of Mobile (Endoscopy & Biopsy Facility) | Mobile | Alabama | 36608 | — |
| Arizona Retina Institute/ Phoenix Retina Associates(OCT) | Peoria | Arizona | 85381 | — |
| SimonMed Imaging (Imaging) | Peoria | Arizona | 85381 | — |
| Sun City Endoscopy Center (Endoscopy) | Sun City | Arizona | 85351 | — |
| Om Research LLC | Apple Valley | California | 92307 | — |
| Victor Valley Advanced Imaging | Apple Valley | California | 92307 | — |
| Koman Family Outpatient Pavilion (ENDO) | La Jolla | California | 92037 | — |
| Perlman Medical Offices | La Jolla | California | 92037 | — |
| UCSD Clinical and Translational Research Institute | La Jolla | California | 92037 | — |
| UCSD Health System (Endo/PFT/DLCO) | La Jolla | California | 92037 | — |
| UCSD lnvestigational Drug Service Pharmacy | La Jolla | California | 92037 | — |
| Shiley Eye Institute (OCT) | La Jolla | California | 92093 | — |
| A V Pediatrics, Allergy and Family Medicine - PFT | Lancaster | California | 93534 | — |
| Advanced Endoscopy and Pain Center - Colonoscopy | Lancaster | California | 93534 | — |
| Advanced Imaging Center - Chest X-Ray | Lancaster | California | 93534 | — |
| Antelope Valley Eye Care - Ophthalmologist | Lancaster | California | 93534 | — |
| AV Pediatrics Allergy and Family Medicine | Lancaster | California | 93534 | — |
| Jatinder S. Pruthi, MD FACG CPI | Lancaster | California | 93534 | — |
| OM Research LLC | Lancaster | California | 93534 | — |
| United Medical Doctors | Murrieta | California | 92563 | — |
| Retina Consultants of Southern California | Victorville | California | 92392 | — |
| Physicians Surgery Center | Victorville | California | 92395 | — |
| Front Range Endoscopy Center | Colorado Springs | Colorado | 80903 | — |
| Peak Gastroenterology Associates | Colorado Springs | Colorado | 80907 | — |
| Colorado Springs Pulmonary Consultants, PC | Colorado Springs | Colorado | 80909 | — |
| The Wright Eye Center (OCT Facility) | Colorado Springs | Colorado | 80909 | — |
| Colorado Springs Imaging (Ultrasound and MRE Location) | Colorado Springs | Colorado | 80919 | — |
| Xera Med Research | Boca Raton | Florida | 33487 | — |
| RecioMed Clinical Research Network, Inc | Boynton Beach | Florida | 33472 | — |
| Florida Advanced Gastroenterology Center - Rahman Nakshabendi MD and Imad Nakshabendi, MD | Brandon | Florida | 33511 | — |
| Bay Area Chest Physicians, P.A. (Pulmonary Function Test) | Clearwater | Florida | 33756 | — |
| West Coast Endoscopy Center (Endoscopy Procedures) | Clearwater | Florida | 33756 | — |
| Northwood Vision (Optical Coherence Tomography) | Clearwater | Florida | 33761 | — |
| Safety Harbor Surgery (Endoscopy Procedures) | Clearwater | Florida | 33761 | — |
| Gastro Florida (Regulatory Administrative Duties) | Clearwater | Florida | 33762 | — |
| Beraja Medical Institute (OCT) | Coral Gables | Florida | 33134 | — |
| Advanced Eye Center | Hialeah | Florida | 33012 | — |
| UF Health Imaging Center-Emerson (chest x-rays) | Jacksonville | Florida | 32207 | — |
| UF Health Laboratory Emerson (blood draws) | Jacksonville | Florida | 32207 | — |
| UF Health Jacksonville Respiratory Therapy (PFT and DLCO) | Jacksonville | Florida | 32209 | — |
| UF Health Jacksonville-Faculty Clinic (ileocolonoscopy and biopsy) | Jacksonville | Florida | 32209 | — |
| UF Health Opthalmology - Jacksonville (Ophthalmology with OCT) | Jacksonville | Florida | 32209 | — |
| UF Health Radiology-Jacksonville (chest x-rays) | Jacksonville | Florida | 32209 | — |
| Cisca Pulmonary & Critical Care (PFT Facility) | Jacksonville | Florida | 32216 | — |
| Nicolitz Eye Consultants (OCT Facility) | Jacksonville | Florida | 32216 | — |
| Borland-Groover Clinic (Endoscopy Facility) | Jacksonville | Florida | 32256 | — |
| Encore Borland-Groover Clinical Research | Jacksonville | Florida | 32256 | — |
| Jupiter Outpatient Surgery Center | Jupiter | Florida | 33458 | — |
| IHS Health, LLC | Kissimmee | Florida | 34741 | — |
| Lee Shettle Eye & Hearing (Ophthalmoscopy Only) | Largo | Florida | 33773 | — |
| Infinite Clinical Research | Miami | Florida | 33133 | — |
| Pulmonology Physicians of South Florida | Miami | Florida | 33133 | — |
| Reina Eye Care P.A. | Miami | Florida | 33133 | — |
| The Endoscopy Center (Endoscopy Procedure) | Miami | Florida | 33134 | — |
| La Salud Research Clinic Inc. | Miami | Florida | 33155 | — |
| Research Associates of South Florida | Miami | Florida | 33156 | — |
| South Florida Center for Endoscopy and Digestive Disease, LLC | Miami | Florida | 33156 | — |
| Juan Barrio, MD (PFT when needed) | Miami | Florida | 33173 | — |
| Anchor Medical Research, Llc | Miami | Florida | 33176 | — |
| Gastroenterology Group of Naples | Naples | Florida | 34102 | — |
| Gulfshore Endoscopy Center | Naples | Florida | 34102 | — |
| Retina Consultants of Southwest Florida OCT only | Naples | Florida | 34103 | — |
| Lisette Delgado Sanchez, MD PFT only | Naples | Florida | 34109 | — |
| Pediatric & Adult Research Center | Orlando | Florida | 32825 | — |
| IMIC Inc. | Palmetto Bay | Florida | 33157 | — |
| IMIC Inc | Palmetto Bay | Florida | 33157 | — |
| Advanced Medical Research Center | Port Orange | Florida | 32127 | — |
| Bardmoor GastroEnterology | Seminole | Florida | 33777 | — |
| Larkin Community Hospital (Endoscopy Procedure) | South Miami | Florida | 33143 | — |
| St. Petersburg Endoscopy Center (Endoscopy Procedures) | St. Petersburg | Florida | 33705 | — |
| Pasadena Center for Asthma and Lung Disorders (PFT and DLCO Only) | St. Petersburg | Florida | 33707 | — |
| Bay Area Endoscopy and Surgery Center (Endoscopy only) | St. Petersburg | Florida | 33709 | — |
| Theia Clinical Research, LLC | St. Petersburg | Florida | 33709 | — |
| Advanced Research Institute Inc.(IP and PFT) | St. Petersburg | Florida | 33710 | — |
| Absolute Surgical Specialist - Craig Amshel, MD | Sun City Center | Florida | 33573 | — |
| Lab - Processing/ Storage | Tampa | Florida | 33606 | — |
| USF Health South Tampa Center for Advanced Healthcare | Tampa | Florida | 33606 | — |
| GCP Clinical Research,LLC | Tampa | Florida | 33609 | — |
| LoCicero Medical Group | Tampa | Florida | 33609 | — |
| Newsome Eye Specialist (OCT Procedures Only) | Tampa | Florida | 33609 | — |
| South Tampa Surgery Center | Tampa | Florida | 33609 | — |
| USF Health Morsani Center For Advanced Healthcare | Tampa | Florida | 33612 | — |
| Digestive Healthcare of Georgia | Atlanta | Georgia | 30309 | — |
| Peachtree Allergy and Asthma Clinic - Chest X-rays and PFTs | Atlanta | Georgia | 30309 | — |
| Ross Eyecare - Opthalmoscopy and OCT | Atlanta | Georgia | 30324 | — |
| Atlanta Gastroenterology Associates (endoscopy only) | Atlanta | Georgia | 30342 | — |
| Atlanta Gastroenterology Associates(IP only) | Atlanta | Georgia | 30342 | — |
| Atlanta Gastroenterology Associates | Atlanta | Georgia | 30342 | — |
| GI Alliance | Arlington Heights | Illinois | 60005 | — |
| Northwest Endoscopy Center (Endoscopy) | Arlington Heights | Illinois | 60005 | — |
| GI Alliance (PFT) | Gurnee | Illinois | 60031 | — |
| Illinois Gastroenterology Group-Gurnee (Patients Seen; IP Delivered) | Gurnee | Illinois | 60031 | — |
| Medical Eye Services LTD (Ophthalmoscopy with OCT) | Gurnee | Illinois | 60031 | — |
| North Shore Endoscopy Center (Endoscopy) | Lake Bluff | Illinois | 60044 | — |
| Libertyville Imaging Center (Diagnostic Imaging) | Libertyville | Illinois | 60048 | — |
| 3T Imaging of Morton Grove (Diagnostic Imaging) | Morton Grove | Illinois | 60053 | — |
| Charter Radiology | Columbia | Maryland | 21044 | — |
| Cascades Endoscopy Center | Columbia | Maryland | 21045 | — |
| Gastro Center of Maryland, LLC | Columbia | Maryland | 21045 | — |
| Kaylani Eye Care ( Optical Coherence Tomography and Opthalmoscopy only) | Hanover | Maryland | 21076 | — |
| Lung Center (Pulmonary Function Test only) | Laurel | Maryland | 20707 | — |
| A Terrell Williams, MD, PLLC (OCT) | Jackson | Mississippi | 39216 | — |
| Jackson Pulmonary Associates (PFT) | Jackson | Mississippi | 39216 | — |
| Southern Therapy and Advanced Research, LLC | Jackson | Mississippi | 39216 | — |
| St. Dominic Ambulatory Surgery Center (colonoscopy, Endoscopy) | Jackson | Mississippi | 39216 | — |
| Barnes-Jewish West County Hospital (Additional Endoscopy Location) | Creve Coeur | Missouri | 63141 | — |
| Washington University School of Medicine | St Louis | Missouri | 63108 | — |
| Barnes-Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Allied Health Clinical Research Organization, LLC | Freehold | New Jersey | 07728 | — |
| Freehold Endoscopy Associates, LLC d/b/a Endoscopy Center of Monmouth County | Freehold | New Jersey | 07728 | — |
| Freehold Ophthalmology | Freehold | New Jersey | 07728 | — |
| Monmouth Ocean Pulmonary Medicine | Freehold | New Jersey | 07728 | — |
| Princeton Radiology | Freehold | New Jersey | 07728 | — |
| NYU Langone Eye Center (Ophthalmology) | New York | New York | 10016 | — |
| NYU Langone Health - Ambulatory Care Center | New York | New York | 10016 | — |
| NYU Langone Health, Investigational Pharmacy, Perlmutter Cancer Center | New York | New York | 10016 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| NYU Langone Inflammatory Bowel Disease Center | New York | New York | 10016 | — |
| NYU Pulmonary and Critical Care Associates (Pulmonary) | New York | New York | 10016 | — |
| Queen City Gastroenterology and Hepatology (Endoscopy) | Charlotte | North Carolina | 28204 | — |
| Greenman Eye Associates (OCT) | Charlotte | North Carolina | 28211 | — |
| Carolinas Research Center | Charlotte | North Carolina | 28215 | — |
| Cornerstone Medical (Imaging & PFT) | Charlotte | North Carolina | 28273 | — |
| Geauga Sleep Center(PFT only) | Chardon | Ohio | 44024 | — |
| UC Health Hoxworth (OCT only) | Cincinnati | Ohio | 45219 | — |
| UC Health Physicians Office | Cincinnati | Ohio | 45219 | — |
| University of Cincinnati Medical Center (PFT and Endoscopy location) | Cincinnati | Ohio | 45219 | — |
| UC Health (Pulmonary Function Testing) | Cincinnati | Ohio | 45229 | — |
| Great Lakes Gastroenterology Research, LLC | Mentor | Ohio | 44060 | — |
| Ophthalmic Physicians Incorporated (OCT Only) | Mentor | Ohio | 44060 | — |
| The Endoscopy Center of Lake County | Mentor | Ohio | 44060 | — |
| Vitreo Retinal Consultants(OCT only) | Mentor | Ohio | 44060 | — |
| Lake Pulmonary Associates (PFT only) | Willoughby | Ohio | 44094 | — |
| Retina Specialists of Ohio(OCT only) | Willoughby Hills | Ohio | 44094 | — |
| Norman Endoscopy Center | Norman | Oklahoma | 73071 | — |
| Physicians and Surgeons X-Ray | Norman | Oklahoma | 73071 | — |
| Hightower Clinical | Oklahoma City | Oklahoma | 73102 | — |
| Saint Anthony Endoscopy Center | Oklahoma City | Oklahoma | 73102 | — |
| SSM Health, Saint Anthony Hospital | Oklahoma City | Oklahoma | 73102 | — |
| Central Sooner Research | Oklahoma City | Oklahoma | 73118 | — |
| Johnston Opthalmology | Oklahoma City | Oklahoma | 73120 | — |
| Penn State Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Central Texas Clinical Research | Austin | Texas | 78705 | — |
| Houston Pulmonary Sleep and Allergy Associates (PFT) | Cypress | Texas | 77429 | — |
| Houston Eye Associates (For Eye Examination) | Houston | Texas | 77024 | — |
| Alkek Eye Center Jamail Specialty Care Center (OCT) | Houston | Texas | 77030 | — |
| Baylor College of Medicine - Baylor St. Luke's Medical Center | Houston | Texas | 77030 | — |
| Baylor St. Luke's Medical Center - McNair Campus (pharmacy) | Houston | Texas | 77030 | — |
| Baylor St. Luke's Medical Center - McNair Campus | Houston | Texas | 77030 | — |
| Baylor St. Luke's Medical Center Endoscopy - McNair Campus | Houston | Texas | 77030 | — |
| Baylor St. Luke's Medical Center | Houston | Texas | 77030 | — |
| Mann Eye Institute | Houston | Texas | 77030 | — |
| Memorial Hermann Hospital- TMC Investigational Drugs Services Pharmacy (Drug Storage) | Houston | Texas | 77030 | — |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | — |
| Bay Area Endoscopy Center, LLC | Houston | Texas | 77034 | — |
| Pearland Surgery Center | Houston | Texas | 77047 | — |
| Memorial Endoscopy Center (For Colonoscopy) | Houston | Texas | 77055 | — |
| Eye Specialists of Texas | Houston | Texas | 77065 | — |
| Northside Gastroenterology Associates PA | Houston | Texas | 77065 | — |
| Memorial Pulmonology(For PFT) | Houston | Texas | 77079 | — |
| Digestive Health Associates | Houston | Texas | 77204 | — |
| Memorial Hermann Memorial City Digestive Health Center (For Colonoscopy) | Houston | Texas | 77204 | — |
| LinQ Research, LLC | Pearland | Texas | 77584 | — |
| Christus Trinity Mother Frances Endoscopy Center (endoscopies only) | Tyler | Texas | 75701 | — |
| Heaton Eye Associates (OCT only) | Tyler | Texas | 75701 | — |
| Tyler Research Institute, LLC | Tyler | Texas | 75701 | — |
| UT Health East Texas Physicians (pulmonary functions only) | Tyler | Texas | 75701 | — |
| Citizens Healthplex (for PFT only) | Victoria | Texas | 77904 | — |
| Surgery Center (For endoscopy only) | Victoria | Texas | 77904 | — |
| Victoria Eye Center (For OCT only) | Victoria | Texas | 77904 | — |
| Victoria Gastroenterology | Victoria | Texas | 77904 | — |
| GI Alliance Webster | Webster | Texas | 77598 | — |
| Harman Eye Center (OCT only) | Forest | Virginia | 24551 | — |
| Lynchburg Pulmonary Associates, Inc. (PFT only) | Lynchburg | Virginia | 24501 | — |
| Blue Ridge Medical Research | Lynchburg | Virginia | 24502 | — |
| Swedish Endoscopy Center - Issaquah | Issaquah | Washington | 98029 | — |
| Pacific Northwest Retina | Seattle | Washington | 98104 | — |
| Richard Bensinger, MD | Seattle | Washington | 98104 | — |
| Swedish Gastroenterology | Seattle | Washington | 98104 | — |
| First Hill Endoscopy Center | Seattle | Washington | 98122 | — |
| Pulmonary Function Lab | Seattle | Washington | 98122 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| Froedtert Memorial Lutheran Hospital | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 318 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04173273, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 1, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04173273 live on ClinicalTrials.gov.