A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
Public ClinicalTrials.gov record NCT04184622. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Efficacy and Safety of Tirzepatide Once Weekly in Participants Without Type 2 Diabetes Who Have Obesity or Are Overweight With Weight- Related Comorbidities: A Randomized, Double-Blind, Placebo-Controlled Trial (SURMOUNT-1)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study of tirzepatide in participants with overweight and obesity. The main purpose is to learn more about how tirzepatide affects body weight. The study has two phases: A main phase and an extension phase. The main phase of the study will last 72 weeks. Participants with prediabetes will continue in the extension for another 2 years.
Study identification
- NCT ID
- NCT04184622
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,539 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 4, 2019 (Actual)
- Primary completion
- Apr 1, 2022 (Actual)
- Completion
- Jul 6, 2024 (Actual)
- Last update posted
- Jul 24, 2025
2019 – 2024
United States locations
- U.S. sites
- 54
- U.S. states
- 27
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cahaba Research | Pelham | Alabama | 35124 | — |
| Perseverance Research Center | Scottsdale | Arizona | 85224 | — |
| John Muir Physician Network Clinical Research Center | Concord | California | 94520 | — |
| Valley Research | Fresno | California | 93720 | — |
| National Research Institute - Wilshire | Los Angeles | California | 90057 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Encompass Clinical Research | Spring Valley | California | 91978 | — |
| University Clinical Investigators, Inc. | Tustin | California | 92780 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06519 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Renstar Medical Research | Ocala | Florida | 34471 | — |
| Oviedo Medical Research | Oviedo | Florida | 32765 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | — |
| Herman Clinical Research | Suwanee | Georgia | 30024 | — |
| SKY Integrative Medical Center/SKYCRNG | Union City | Georgia | 30291 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| Midwest Institute for Clinical Research | Indianapolis | Indiana | 46260 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50265 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| NECCR PrimaCare Research | Fall River | Massachusetts | 02721 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Palm Research Center Sunset | Las Vegas | Nevada | 89148 | — |
| Premier Research | Trenton | New Jersey | 08611 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | — |
| University of North Carolina Medical Center | Chapel Hill | North Carolina | 27514 | — |
| PharmQuest | Greensboro | North Carolina | 27408 | — |
| Lillestol Research | Fargo | North Dakota | 58104 | — |
| Velocity Clinical Research, Cleveland | Cleveland | Ohio | 44122 | — |
| Aventiv Research Inc | Columbus | Ohio | 43213 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Summit Research Network | Portland | Oregon | 97210 | — |
| Detweiler Family Medicine & Associates | Lansdale | Pennsylvania | 19446 | — |
| Preferred Primary Care Physicians | Uniontown | Pennsylvania | 15401 | — |
| Velocity Clinical Research, Providence | East Greenwich | Rhode Island | 02818 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Mountain View Clinical Research, Inc. | Greer | South Carolina | 29651 | — |
| Coastal Carolina Research Center | North Charleston | South Carolina | 29405 | — |
| WR-Clinsearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Texas Diabetes & Endocrinology, P.A. | Austin | Texas | 78749 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Research Institute of Dallas | Dallas | Texas | 75231 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Texas Diabetes & Endocrinology, P.A. | Round Rock | Texas | 78681 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 64 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04184622, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 24, 2025 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04184622 live on ClinicalTrials.gov.