A Study for the Identification of Biomarker Signatures for Early Detection of Pulmonary Hypertension (PH)
Public ClinicalTrials.gov record NCT04193046. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Prospective, Multicenter Study for the Identification of Biomarker Signatures for the Early Detection of Pulmonary Hypertension (PH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary purpose of this study is to identify and develop biomarker signatures based on circulating micro ribonucleic acid (RNA) in the blood samples associated with high risk of pulmonary hypertension (PH) to assist in the diagnosis of PH; to estimate the sensitivity, specificity, positive predictive value, and negative predictive value of the biomarker signatures in identifying participants with PH by comparing the biomarker signatures to right heart catheterization (RHC) and to compare the sensitivity, specificity, positive predictive value, and negative predictive value of the biomarker signatures with the sensitivity, specificity, positive predictive value, and negative predictive value of transthoracic echocardiogram (TTE) in identifying participants with PH documented by RHC.
Study identification
- NCT ID
- NCT04193046
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Early Phase 1
- Enrollment
- 907 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2019 (Actual)
- Primary completion
- Dec 20, 2021 (Actual)
- Completion
- Feb 18, 2022 (Actual)
- Last update posted
- Sep 12, 2025
2019 – 2022
United States locations
- U.S. sites
- 16
- U.S. states
- 13
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Southern California | Los Angeles | California | 90033 | — |
| University Of Colorado Cardiac And Vascular Center | Aurora | Colorado | 80045-2548 | — |
| Ascension St. Vincent's Lung Institute | Jacksonville | Florida | 32204 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| University Of Iowa - Hospitals & Clinics | Iowa City | Iowa | 52242 | — |
| Norton Pulmonary Specialists | Louisville | Kentucky | 40202 | — |
| LSU Health Sciences Center New Orleans | New Orleans | Louisiana | 70112 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111-1552 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-5990 | — |
| Pulmonary Health Physicians, PC | Liverpool | New York | 13088 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-8550 | — |
| The Houston Methodist Research Institute | Houston | Texas | 77030 | — |
| Pulmonary Associates Of Richmond | Richmond | Virginia | 23230 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04193046, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 12, 2025 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04193046 live on ClinicalTrials.gov.