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ClinicalTrials.gov record
Active, not recruiting Phase 3 Interventional

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

ClinicalTrials.gov ID: NCT04214067

Public ClinicalTrials.gov record NCT04214067. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 20, 2026, 10:52 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Randomized Trial of Radiation +/- Pembrolizumab (MK-3475) for Newly Diagnosed Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase III trial compares whether the addition of pembrolizumab to radiation therapy is more effective than radiation therapy alone in reducing the risk of cancer coming back (recurrence) in patients with newly diagnosed stage I-II endometrial cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. The addition of pembrolizumab to radiation treatment may be more effective than radiation treatment alone in reducing cancer recurrence.

Study identification

NCT ID
NCT04214067
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Enrollment
164 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 9, 2020 (Actual)
Primary completion
Dec 30, 2025 (Actual)
Completion
Feb 5, 2027 (Estimated)
Last update posted
Jul 2, 2026

2020 – 2027

United States locations

U.S. sites
275
U.S. states
39
U.S. cities
198
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 —
Community Cancer Institute Clovis California 93611 —
University Oncology Associates Clovis California 93611 —
John Muir Medical Center-Concord Concord California 94520 —
UC San Diego Moores Cancer Center La Jolla California 92093 —
Los Angeles General Medical Center Los Angeles California 90033 —
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 —
UCLA / Jonsson Comprehensive Cancer Center Los Angeles California 90095 —
UCSF Medical Center-Mission Bay San Francisco California 94158 —
John Muir Medical Center-Walnut Creek Walnut Creek California 94598 —
UCHealth University of Colorado Hospital Aurora Colorado 80045 —
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907 —
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909 —
Memorial Hospital North Colorado Springs Colorado 80920 —
AdventHealth Porter Denver Colorado 80210 —
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129 —
AdventHealth Littleton Littleton Colorado 80122 —
AdventHealth Parker Parker Colorado 80138 —
Danbury Hospital Danbury Connecticut 06810 —
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418 —
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824 —
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033 —
Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut 06830 —
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437 —
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105 —
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510 —
Yale University New Haven Connecticut 06520 —
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473 —
Norwalk Hospital Norwalk Connecticut 06856 —
Smilow Cancer Hospital-Orange Care Center Orange Connecticut 06477 —
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790 —
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 —
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708 —
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 —
GenesisCare USA - FGO Fort Myers Florida 33905 —
Regional Cancer Center-Lee Memorial Health System Fort Myers Florida 33905 —
Northside Hospital Atlanta Georgia 30342 —
Northside Hospital-Forsyth Cumming Georgia 30041 —
Wellstar Kennestone Hospital Marietta Georgia 30060 —
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265 —
Memorial Health University Medical Center Savannah Georgia 31404 —
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405 —
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813 —
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813 —
Queen's Medical Center Honolulu Hawaii 96813 —
Straub Clinic and Hospital Honolulu Hawaii 96813 —
University of Hawaii Cancer Center Honolulu Hawaii 96813 —
Hawaii Cancer Care Inc-Liliha Honolulu Hawaii 96817 —
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817 —
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817 —
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826 —
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766 —
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701 —
Pali Momi Medical Center ‘Aiea Hawaii 96701 —
Saint Luke's Cancer Institute - Boise Boise Idaho 83712 —
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619 —
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642 —
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687 —
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301 —
Centralia Oncology Clinic Centralia Illinois 62801 —
Northwestern University Chicago Illinois 60611 —
Rush MD Anderson Cancer Center Chicago Illinois 60612 —
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 —
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526 —
Decatur Memorial Hospital Decatur Illinois 62526 —
Crossroads Cancer Center Effingham Illinois 62401 —
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201 —
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134 —
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026 —
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035 —
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045 —
Loyola University Medical Center Maywood Illinois 60153 —
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 —
Cancer Care Center of O'Fallon O'Fallon Illinois 62269 —
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 —
Southern Illinois University School of Medicine Springfield Illinois 62702 —
Springfield Clinic Springfield Illinois 62702 —
Springfield Memorial Hospital Springfield Illinois 62781 —
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555 —
Midwestern Regional Medical Center Zion Illinois 60099 —
Ascension Saint Vincent Indianapolis Hospital Indianapolis Indiana 46260 —
Mary Greeley Medical Center Ames Iowa 50010 —
McFarland Clinic - Ames Ames Iowa 50010 —
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242 —
Saint Elizabeth Healthcare Edgewood Edgewood Kentucky 41017 —
Baptist Health Lexington Lexington Kentucky 40503 —
Baptist Health Louisville Louisville Kentucky 40207 —
East Jefferson General Hospital Metairie Louisiana 70006 —
Louisiana State University Health Science Center New Orleans Louisiana 70112 —
University Medical Center New Orleans New Orleans Louisiana 70112 —
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530 —
MaineHealth Maine Medical Center - Biddeford Biddeford Maine 04005 —
MaineHealth Maine Medical Center - Portland Portland Maine 04102 —
MaineHealth Cancer Care and IV Therapy - Sanford Sanford Maine 04073 —
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074 —
Sinai Hospital of Baltimore Baltimore Maryland 21215 —
Corewell Health Dearborn Hospital Dearborn Michigan 48124 —
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201 —
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334 —
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073 —
Corewell Health Beaumont Troy Hospital Troy Michigan 48085 —
Minnesota Oncology - Burnsville Burnsville Minnesota 55337 —
Mercy Hospital Coon Rapids Minnesota 55433 —
Fairview Southdale Hospital Edina Minnesota 55435 —
Unity Hospital Fridley Minnesota 55432 —
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109 —
Abbott-Northwestern Hospital Minneapolis Minnesota 55407 —
Monticello Cancer Center Monticello Minnesota 55362 —
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303 —
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416 —
United Hospital Saint Paul Minnesota 55102 —
Ridgeview Medical Center Waconia Minnesota 55387 —
Rice Memorial Hospital Willmar Minnesota 56201 —
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125 —
Parkland Health Center - Farmington Farmington Missouri 63640 —
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670 —
Mercy Hospital Springfield Springfield Missouri 65804 —
CoxHealth South Hospital Springfield Missouri 65807 —
Washington University School of Medicine St Louis Missouri 63110 —
Mercy Hospital South St Louis Missouri 63128 —
Missouri Baptist Medical Center St Louis Missouri 63131 —
Mercy Hospital Saint Louis St Louis Missouri 63141 —
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080 —
BJC Outpatient Center at Sunset Hills Sunset Hills Missouri 63127 —
Billings Clinic Cancer Center Billings Montana 59101 —
Bozeman Health Deaconess Hospital Bozeman Montana 59715 —
Community Medical Center Missoula Montana 59804 —
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska 68114 —
Nebraska Methodist Hospital Omaha Nebraska 68114 —
Oncology Associates PC Omaha Nebraska 68114 —
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124 —
Women's Cancer Center of Nevada Las Vegas Nevada 89106 —
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 —
Cooper Hospital University Medical Center Camden New Jersey 08103 —
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 —
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 —
Virtua Samson Cancer Center Moorestown New Jersey 08057 —
Jersey Shore Medical Center Neptune City New Jersey 07753 —
Virtua Voorhees Voorhees Township New Jersey 08043 —
University of New Mexico Cancer Center Albuquerque New Mexico 87106 —
Women's Cancer Care Associates LLC Albany New York 12208 —
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215 —
Memorial Sloan Kettering Commack Commack New York 11725 —
The New York Hospital Medical Center of Queens Flushing New York 11355 —
Memorial Sloan Kettering Westchester Harrison New York 10604 —
Northwell Health/Center for Advanced Medicine Lake Success New York 11042 —
NYU Langone Hospital - Long Island Mineola New York 11501 —
Long Island Jewish Medical Center New Hyde Park New York 11040 —
Mount Sinai Chelsea New York New York 10011 —
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016 —
Mount Sinai West New York New York 10019 —
Mount Sinai Hospital New York New York 10029 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
NYP/Weill Cornell Medical Center New York New York 10065 —
Highland Hospital Rochester New York 14620 —
University of Rochester Rochester New York 14642 —
Stony Brook University Medical Center Stony Brook New York 11794 —
Memorial Sloan Kettering Nassau Uniondale New York 11553 —
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 —
Duke University Medical Center Durham North Carolina 27710 —
Cone Health Cancer Center Greensboro North Carolina 27403 —
Duke Women's Cancer Care Raleigh Raleigh North Carolina 27607 —
Duke Cancer Center Raleigh Raleigh North Carolina 27609 —
Sanford Bismarck Medical Center Bismarck North Dakota 58501 —
Sanford Broadway Medical Center Fargo North Dakota 58122 —
Sanford Roger Maris Cancer Center Fargo North Dakota 58122 —
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122 —
Aultman Health Foundation Canton Ohio 44710 —
Dayton Physicians LLC-Miami Valley South Centerville Ohio 45459 —
Miami Valley Hospital South Centerville Ohio 45459 —
Geauga Hospital Chardon Ohio 44024 —
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220 —
Bethesda North Hospital Cincinnati Ohio 45242 —
Case Western Reserve University Cleveland Ohio 44106 —
MetroHealth Medical Center Cleveland Ohio 44109 —
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111 —
Cleveland Clinic Foundation Cleveland Ohio 44195 —
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210 —
Mount Carmel East Hospital Columbus Ohio 43213 —
Riverside Methodist Hospital Columbus Ohio 43214 —
The Mark H Zangmeister Center Columbus Ohio 43219 —
Mount Carmel Health Center West Columbus Ohio 43222 —
Dayton Physician LLC - Englewood Dayton Ohio 45415 —
Miami Valley Hospital North Dayton Ohio 45415 —
Dublin Methodist Hospital Dublin Ohio 43016 —
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066 —
Dayton Physicians LLC-Atrium Franklin Ohio 45005 —
Mount Carmel Grove City Hospital Grove City Ohio 43123 —
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124 —
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060 —
Mount Carmel New Albany Surgical Hospital New Albany Ohio 43054 —
University Hospitals Sharon Health Center Wadsworth Ohio 44281 —
Saint Ann's Hospital Westerville Ohio 43081 —
UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio 44145 —
UHHS-Westlake Medical Center Westlake Ohio 44145 —
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701 —
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 —
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120 —
Clackamas Radiation Oncology Center Clackamas Oregon 97015 —
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015 —
Legacy Mount Hood Medical Center Gresham Oregon 97030 —
Providence Newberg Medical Center Newberg Oregon 97132 —
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210 —
Providence Portland Medical Center Portland Oregon 97213 —
Providence Saint Vincent Medical Center Portland Oregon 97225 —
Legacy Meridian Park Hospital Tualatin Oregon 97062 —
Carlisle Regional Cancer Center Carlisle Pennsylvania 17015 —
Ephrata Cancer Center Ephrata Pennsylvania 17522 —
Adams Cancer Center Gettysburg Pennsylvania 17325 —
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601 —
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania 17109 —
Lancaster General Ann B Barshinger Cancer Institute Lancaster Pennsylvania 17601 —
Lancaster General Hospital Lancaster Pennsylvania 17602 —
Sechler Family Cancer Center Lebanon Pennsylvania 17042 —
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050 —
Paoli Memorial Hospital Paoli Pennsylvania 19301 —
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104 —
Pennsylvania Hospital Philadelphia Pennsylvania 19107 —
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 —
UPMC-Magee Womens Hospital Pittsburgh Pennsylvania 15213 —
Chester County Hospital West Chester Pennsylvania 19380 —
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090 —
Lankenau Medical Center Wynnewood Pennsylvania 19096 —
WellSpan Health-York Cancer Center York Pennsylvania 17403 —
WellSpan Health-York Hospital York Pennsylvania 17403 —
Women and Infants Hospital Providence Rhode Island 02905 —
Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island 02891 —
Saint Joseph's/Candler - Bluffton Campus Bluffton South Carolina 29910 —
Saint Francis Hospital Greenville South Carolina 29601 —
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605 —
Saint Francis Cancer Center Greenville South Carolina 29607 —
Rapid City Regional Hospital Rapid City South Dakota 57701 —
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104 —
Avera Cancer Institute Sioux Falls South Dakota 57105 —
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134 —
UT MD Anderson - The Woodlands Conroe Texas 77384 —
Parkland Memorial Hospital Dallas Texas 75235 —
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390 —
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030 —
Ben Taub General Hospital Houston Texas 77030 —
Houston Methodist Hospital Houston Texas 77030 —
UT MD Anderson Cancer Center Houston Texas 77030 —
Methodist Willowbrook Hospital Houston Texas 77070 —
UT MD Anderson - West Houston Houston Texas 77079 —
Houston Methodist West Hospital Houston Texas 77094 —
UT MD Anderson - League City League City Texas 77573 —
UT MD Anderson - Sugar Land Sugar Land Texas 77478 —
Houston Methodist Sugar Land Hospital Sugar Land Texas 77479 —
Houston Methodist The Woodlands Hospital The Woodlands Texas 77385 —
Farmington Health Center Farmington Utah 84025 —
University of Utah Sugarhouse Health Center Salt Lake City Utah 84106 —
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 —
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235 —
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 —
Carilion Roanoke Memorial Hospital Roanoke Virginia 24033 —
Legacy Salmon Creek Hospital Vancouver Washington 98686 —
West Virginia University Charleston Division Charleston West Virginia 25304 —
Ascension Southeast Wisconsin Hospital-Elmbrook Campus-Brookfield Brookfield Wisconsin 53045 —
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701 —
Ascension Southeast Wisconsin Hospital - Franklin Franklin Wisconsin 53132 —
Reiman Cancer Center-Ascension Wisconsin Health Center-Rawson Franklin Wisconsin 53132 —
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601 —
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792 —
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449 —
Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon Mequon Wisconsin 53097 —
Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee Milwaukee Wisconsin 53210 —
Ascension Columbia Saint Mary's Hospital-Milwaukee Campus Milwaukee Wisconsin 53211 —
Ascension Saint Francis Hospital-Milwaukee Milwaukee Wisconsin 53215 —
Medical College of Wisconsin Milwaukee Wisconsin 53226 —
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548 —
Ascension All Saints Hospital-Spring Street-Racine Racine Wisconsin 53405 —
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868 —
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482 —
Ascension Southeast Wisconsin Hospital-Mayfair Road-Wauwatosa Wauwatosa Wisconsin 53226 —
Marshfield Medical Center - Weston Weston Wisconsin 54476 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04214067, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 2, 2026 · Synced Oct 20, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT04214067 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →