ClinicalTrials.gov record
Active, not recruiting Phase 3 Interventional

Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to the Usual Radiation Treatment for Newly Diagnosed Early Stage High Intermediate Risk Endometrial Cancer

ClinicalTrials.gov ID: NCT04214067

Public ClinicalTrials.gov record NCT04214067. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced May 9, 2026, 1:06 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase III Randomized Trial of Radiation +/- Pembrolizumab (MK-3475) for Newly Diagnosed Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial Cancer

Study identification

NCT ID
NCT04214067
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
164 participants

Conditions and interventions

Interventions

  • Biospecimen Collection Procedure
  • Brachytherapy Radiation
  • Computed Tomography Procedure
  • External Beam Radiation Therapy Radiation
  • Magnetic Resonance Imaging Procedure
  • Pembrolizumab Biological
  • Quality-of-Life Assessment Other
  • Questionnaire Administration Other
  • X-Ray Imaging Procedure

Procedure · Radiation · Biological + 1 more

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 8, 2020
Primary completion
Dec 29, 2025
Completion
Feb 4, 2027
Last update posted
Apr 12, 2026

2020 – 2027

United States locations

U.S. sites
275
U.S. states
39
U.S. cities
198
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233
Community Cancer Institute Clovis California 93611
University Oncology Associates Clovis California 93611
John Muir Medical Center-Concord Concord California 94520
UC San Diego Moores Cancer Center La Jolla California 92093
Los Angeles General Medical Center Los Angeles California 90033
USC / Norris Comprehensive Cancer Center Los Angeles California 90033
UCLA / Jonsson Comprehensive Cancer Center Los Angeles California 90095
UCSF Medical Center-Mission Bay San Francisco California 94158
John Muir Medical Center-Walnut Creek Walnut Creek California 94598
UCHealth University of Colorado Hospital Aurora Colorado 80045
Rocky Mountain Cancer Centers-Penrose Colorado Springs Colorado 80907
UCHealth Memorial Hospital Central Colorado Springs Colorado 80909
Memorial Hospital North Colorado Springs Colorado 80920
AdventHealth Porter Denver Colorado 80210
UCHealth Highlands Ranch Hospital Highlands Ranch Colorado 80129
AdventHealth Littleton Littleton Colorado 80122
AdventHealth Parker Parker Colorado 80138
Danbury Hospital Danbury Connecticut 06810
Smilow Cancer Hospital-Derby Care Center Derby Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield Fairfield Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury Glastonbury Connecticut 06033
Smilow Cancer Hospital Care Center at Greenwich Greenwich Connecticut 06830
Smilow Cancer Hospital Care Center - Guilford Guilford Connecticut 06437
Smilow Cancer Hospital Care Center at Saint Francis Hartford Connecticut 06105
Smilow Cancer Center/Yale-New Haven Hospital New Haven Connecticut 06510
Yale University New Haven Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center North Haven Connecticut 06473
Norwalk Hospital Norwalk Connecticut 06856
Smilow Cancer Hospital-Orange Care Center Orange Connecticut 06477
Smilow Cancer Hospital-Torrington Care Center Torrington Connecticut 06790
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center Waterbury Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385
GenesisCare USA - FGO Fort Myers Florida 33905
Regional Cancer Center-Lee Memorial Health System Fort Myers Florida 33905
Northside Hospital Atlanta Georgia 30342
Northside Hospital-Forsyth Cumming Georgia 30041
Wellstar Kennestone Hospital Marietta Georgia 30060
CTCA at Southeastern Regional Medical Center Newnan Georgia 30265
Memorial Health University Medical Center Savannah Georgia 31404
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler Savannah Georgia 31405
Hawaii Cancer Care Inc - Waterfront Plaza Honolulu Hawaii 96813
Queen's Cancer Cenrer - POB I Honolulu Hawaii 96813
Queen's Medical Center Honolulu Hawaii 96813
Straub Clinic and Hospital Honolulu Hawaii 96813
University of Hawaii Cancer Center Honolulu Hawaii 96813
Hawaii Cancer Care Inc-Liliha Honolulu Hawaii 96817
Queen's Cancer Center - Kuakini Honolulu Hawaii 96817
The Cancer Center of Hawaii-Liliha Honolulu Hawaii 96817
Kapiolani Medical Center for Women and Children Honolulu Hawaii 96826
Wilcox Memorial Hospital and Kauai Medical Clinic Lihue Hawaii 96766
Hawaii Cancer Care - Westridge ‘Aiea Hawaii 96701
Pali Momi Medical Center ‘Aiea Hawaii 96701
Saint Luke's Cancer Institute - Boise Boise Idaho 83712
Saint Luke's Cancer Institute - Fruitland Fruitland Idaho 83619
Saint Luke's Cancer Institute - Meridian Meridian Idaho 83642
Saint Luke's Cancer Institute - Nampa Nampa Idaho 83687
Saint Luke's Cancer Institute - Twin Falls Twin Falls Idaho 83301
Centralia Oncology Clinic Centralia Illinois 62801
Northwestern University Chicago Illinois 60611
Rush MD Anderson Cancer Center Chicago Illinois 60612
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637
Cancer Care Specialists of Illinois - Decatur Decatur Illinois 62526
Decatur Memorial Hospital Decatur Illinois 62526
Crossroads Cancer Center Effingham Illinois 62401
NorthShore University HealthSystem-Evanston Hospital Evanston Illinois 60201
Northwestern Medicine Cancer Center Delnor Geneva Illinois 60134
NorthShore University HealthSystem-Glenbrook Hospital Glenview Illinois 60026
NorthShore University HealthSystem-Highland Park Hospital Highland Park Illinois 60035
Northwestern Medicine Lake Forest Hospital Lake Forest Illinois 60045
Loyola University Medical Center Maywood Illinois 60153
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451
Cancer Care Center of O'Fallon O'Fallon Illinois 62269
University of Chicago Medicine-Orland Park Orland Park Illinois 60462
Southern Illinois University School of Medicine Springfield Illinois 62702
Springfield Clinic Springfield Illinois 62702
Springfield Memorial Hospital Springfield Illinois 62781
Northwestern Medicine Cancer Center Warrenville Warrenville Illinois 60555
Midwestern Regional Medical Center Zion Illinois 60099
Ascension Saint Vincent Indianapolis Hospital Indianapolis Indiana 46260
Mary Greeley Medical Center Ames Iowa 50010
McFarland Clinic - Ames Ames Iowa 50010
University of Iowa/Holden Comprehensive Cancer Center Iowa City Iowa 52242
Saint Elizabeth Healthcare Edgewood Edgewood Kentucky 41017
Baptist Health Lexington Lexington Kentucky 40503
Baptist Health Louisville Louisville Kentucky 40207
East Jefferson General Hospital Metairie Louisiana 70006
Louisiana State University Health Science Center New Orleans Louisiana 70112
University Medical Center New Orleans New Orleans Louisiana 70112
MaineHealth Coastal Cancer Treatment Center Bath Maine 04530
MaineHealth Maine Medical Center - Biddeford Biddeford Maine 04005
MaineHealth Maine Medical Center - Portland Portland Maine 04102
MaineHealth Cancer Care and IV Therapy - Sanford Sanford Maine 04073
MaineHealth Maine Medical Center- Scarborough Scarborough Maine 04074
Sinai Hospital of Baltimore Baltimore Maryland 21215
Corewell Health Dearborn Hospital Dearborn Michigan 48124
Wayne State University/Karmanos Cancer Institute Detroit Michigan 48201
Weisberg Cancer Treatment Center Farmington Hills Michigan 48334
Corewell Health William Beaumont University Hospital Royal Oak Michigan 48073
Corewell Health Beaumont Troy Hospital Troy Michigan 48085
Minnesota Oncology - Burnsville Burnsville Minnesota 55337
Mercy Hospital Coon Rapids Minnesota 55433
Fairview Southdale Hospital Edina Minnesota 55435
Unity Hospital Fridley Minnesota 55432
Minnesota Oncology Hematology PA-Maplewood Maplewood Minnesota 55109
Abbott-Northwestern Hospital Minneapolis Minnesota 55407
Monticello Cancer Center Monticello Minnesota 55362
Coborn Cancer Center at Saint Cloud Hospital Saint Cloud Minnesota 56303
Park Nicollet Clinic - Saint Louis Park Saint Louis Park Minnesota 55416
United Hospital Saint Paul Minnesota 55102
Ridgeview Medical Center Waconia Minnesota 55387
Rice Memorial Hospital Willmar Minnesota 56201
Minnesota Oncology Hematology PA-Woodbury Woodbury Minnesota 55125
Parkland Health Center - Farmington Farmington Missouri 63640
Sainte Genevieve County Memorial Hospital Sainte Genevieve Missouri 63670
Mercy Hospital Springfield Springfield Missouri 65804
CoxHealth South Hospital Springfield Missouri 65807
Washington University School of Medicine St Louis Missouri 63110
Mercy Hospital South St Louis Missouri 63128
Missouri Baptist Medical Center St Louis Missouri 63131
Mercy Hospital Saint Louis St Louis Missouri 63141
Missouri Baptist Sullivan Hospital Sullivan Missouri 63080
BJC Outpatient Center at Sunset Hills Sunset Hills Missouri 63127
Billings Clinic Cancer Center Billings Montana 59101
Bozeman Health Deaconess Hospital Bozeman Montana 59715
Community Medical Center Missoula Montana 59804
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC Omaha Nebraska 68114
Nebraska Methodist Hospital Omaha Nebraska 68114
Oncology Associates PC Omaha Nebraska 68114
Alegent Health Bergan Mercy Medical Center Omaha Nebraska 68124
Women's Cancer Center of Nevada Las Vegas Nevada 89106
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920
Cooper Hospital University Medical Center Camden New Jersey 08103
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748
Memorial Sloan Kettering Bergen Montvale New Jersey 07645
Virtua Samson Cancer Center Moorestown New Jersey 08057
Jersey Shore Medical Center Neptune City New Jersey 07753
Virtua Voorhees Voorhees Township New Jersey 08043
University of New Mexico Cancer Center Albuquerque New Mexico 87106
Women's Cancer Care Associates LLC Albany New York 12208
New York-Presbyterian/Brooklyn Methodist Hospital Brooklyn New York 11215
Memorial Sloan Kettering Commack Commack New York 11725
The New York Hospital Medical Center of Queens Flushing New York 11355
Memorial Sloan Kettering Westchester Harrison New York 10604
Northwell Health/Center for Advanced Medicine Lake Success New York 11042
NYU Langone Hospital - Long Island Mineola New York 11501
Long Island Jewish Medical Center New Hyde Park New York 11040
Mount Sinai Chelsea New York New York 10011
Laura and Isaac Perlmutter Cancer Center at NYU Langone New York New York 10016
Mount Sinai West New York New York 10019
Mount Sinai Hospital New York New York 10029
Memorial Sloan Kettering Cancer Center New York New York 10065
NYP/Weill Cornell Medical Center New York New York 10065
Highland Hospital Rochester New York 14620
University of Rochester Rochester New York 14642
Stony Brook University Medical Center Stony Brook New York 11794
Memorial Sloan Kettering Nassau Uniondale New York 11553
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599
Duke University Medical Center Durham North Carolina 27710
Cone Health Cancer Center Greensboro North Carolina 27403
Duke Women's Cancer Care Raleigh Raleigh North Carolina 27607
Duke Cancer Center Raleigh Raleigh North Carolina 27609
Sanford Bismarck Medical Center Bismarck North Dakota 58501
Sanford Broadway Medical Center Fargo North Dakota 58122
Sanford Roger Maris Cancer Center Fargo North Dakota 58122
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122
Aultman Health Foundation Canton Ohio 44710
Dayton Physicians LLC-Miami Valley South Centerville Ohio 45459
Miami Valley Hospital South Centerville Ohio 45459
Geauga Hospital Chardon Ohio 44024
Good Samaritan Hospital - Cincinnati Cincinnati Ohio 45220
Bethesda North Hospital Cincinnati Ohio 45242
Case Western Reserve University Cleveland Ohio 44106
MetroHealth Medical Center Cleveland Ohio 44109
Cleveland Clinic Cancer Center/Fairview Hospital Cleveland Ohio 44111
Cleveland Clinic Foundation Cleveland Ohio 44195
Ohio State University Comprehensive Cancer Center Columbus Ohio 43210
Mount Carmel East Hospital Columbus Ohio 43213
Riverside Methodist Hospital Columbus Ohio 43214
The Mark H Zangmeister Center Columbus Ohio 43219
Mount Carmel Health Center West Columbus Ohio 43222
Dayton Physician LLC - Englewood Dayton Ohio 45415
Miami Valley Hospital North Dayton Ohio 45415
Dublin Methodist Hospital Dublin Ohio 43016
Atrium Medical Center-Middletown Regional Hospital Franklin Ohio 45005-1066
Dayton Physicians LLC-Atrium Franklin Ohio 45005
Mount Carmel Grove City Hospital Grove City Ohio 43123
Hillcrest Hospital Cancer Center Mayfield Heights Ohio 44124
UH Seidman Cancer Center at Lake Health Mentor Campus Mentor Ohio 44060
Mount Carmel New Albany Surgical Hospital New Albany Ohio 43054
University Hospitals Sharon Health Center Wadsworth Ohio 44281
Saint Ann's Hospital Westerville Ohio 43081
UH Seidman Cancer Center at Saint John Medical Center Westlake Ohio 44145
UHHS-Westlake Medical Center Westlake Ohio 44145
Genesis Healthcare System Cancer Care Center Zanesville Ohio 43701
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104
Mercy Hospital Oklahoma City Oklahoma City Oklahoma 73120
Clackamas Radiation Oncology Center Clackamas Oregon 97015
Providence Cancer Institute Clackamas Clinic Clackamas Oregon 97015
Legacy Mount Hood Medical Center Gresham Oregon 97030
Providence Newberg Medical Center Newberg Oregon 97132
Legacy Good Samaritan Hospital and Medical Center Portland Oregon 97210
Providence Portland Medical Center Portland Oregon 97213
Providence Saint Vincent Medical Center Portland Oregon 97225
Legacy Meridian Park Hospital Tualatin Oregon 97062
Carlisle Regional Cancer Center Carlisle Pennsylvania 17015
Ephrata Cancer Center Ephrata Pennsylvania 17522
Adams Cancer Center Gettysburg Pennsylvania 17325
UPMC Cancer Centers - Arnold Palmer Pavilion Greensburg Pennsylvania 15601
UPMC Pinnacle Cancer Center/Community Osteopathic Campus Harrisburg Pennsylvania 17109
Lancaster General Ann B Barshinger Cancer Institute Lancaster Pennsylvania 17601
Lancaster General Hospital Lancaster Pennsylvania 17602
Sechler Family Cancer Center Lebanon Pennsylvania 17042
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion Mechanicsburg Pennsylvania 17050
Paoli Memorial Hospital Paoli Pennsylvania 19301
University of Pennsylvania/Abramson Cancer Center Philadelphia Pennsylvania 19104
Pennsylvania Hospital Philadelphia Pennsylvania 19107
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107
UPMC-Magee Womens Hospital Pittsburgh Pennsylvania 15213
Chester County Hospital West Chester Pennsylvania 19380
Asplundh Cancer Pavilion Willow Grove Pennsylvania 19090
Lankenau Medical Center Wynnewood Pennsylvania 19096
WellSpan Health-York Cancer Center York Pennsylvania 17403
WellSpan Health-York Hospital York Pennsylvania 17403
Women and Infants Hospital Providence Rhode Island 02905
Smilow Cancer Hospital Care Center - Westerly Westerly Rhode Island 02891
Saint Joseph's/Candler - Bluffton Campus Bluffton South Carolina 29910
Saint Francis Hospital Greenville South Carolina 29601
Prisma Health Cancer Institute - Faris Greenville South Carolina 29605
Saint Francis Cancer Center Greenville South Carolina 29607
Rapid City Regional Hospital Rapid City South Dakota 57701
Sanford Cancer Center Oncology Clinic Sioux Falls South Dakota 57104
Avera Cancer Institute Sioux Falls South Dakota 57105
Sanford USD Medical Center - Sioux Falls Sioux Falls South Dakota 57117-5134
MD Anderson in The Woodlands Conroe Texas 77384
Parkland Memorial Hospital Dallas Texas 75235
UT Southwestern/Simmons Cancer Center-Dallas Dallas Texas 75390
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center Houston Texas 77030
Ben Taub General Hospital Houston Texas 77030
Houston Methodist Hospital Houston Texas 77030
M D Anderson Cancer Center Houston Texas 77030
Methodist Willowbrook Hospital Houston Texas 77070
MD Anderson West Houston Houston Texas 77079
Houston Methodist West Hospital Houston Texas 77094
MD Anderson League City League City Texas 77573
MD Anderson in Sugar Land Sugar Land Texas 77478
Houston Methodist Sugar Land Hospital Sugar Land Texas 77479
Houston Methodist The Woodlands Hospital The Woodlands Texas 77385
Farmington Health Center Farmington Utah 84025
University of Utah Sugarhouse Health Center Salt Lake City Utah 84106
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112
VCU Massey Cancer Center at Stony Point Richmond Virginia 23235
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298
Carilion Roanoke Memorial Hospital Roanoke Virginia 24033
Legacy Salmon Creek Hospital Vancouver Washington 98686
West Virginia University Charleston Division Charleston West Virginia 25304
Ascension Southeast Wisconsin Hospital - Elmbrook Campus Brookfield Wisconsin 53045
Marshfield Medical Center-EC Cancer Center Eau Claire Wisconsin 54701
Ascension Saint Francis - Reiman Cancer Center Franklin Wisconsin 53132
Ascension Southeast Wisconsin Hospital - Franklin Franklin Wisconsin 53132
Gundersen Lutheran Medical Center La Crosse Wisconsin 54601
University of Wisconsin Carbone Cancer Center - University Hospital Madison Wisconsin 53792
Marshfield Medical Center-Marshfield Marshfield Wisconsin 54449
Ascension Columbia Saint Mary's Hospital Ozaukee Mequon Wisconsin 53097
Ascension Southeast Wisconsin Hospital - Saint Joseph Campus Milwaukee Wisconsin 53210
Ascension Columbia Saint Mary's Hospital - Milwaukee Milwaukee Wisconsin 53211
Ascension Saint Francis Hospital Milwaukee Wisconsin 53215
Medical College of Wisconsin Milwaukee Wisconsin 53226
Marshfield Medical Center - Minocqua Minocqua Wisconsin 54548
Ascension All Saints Hospital Racine Wisconsin 53405
Marshfield Medical Center-Rice Lake Rice Lake Wisconsin 54868
Marshfield Medical Center-River Region at Stevens Point Stevens Point Wisconsin 54482
Ascension Medical Group Southeast Wisconsin - Mayfair Road Wauwatosa Wisconsin 53226
Marshfield Medical Center - Weston Weston Wisconsin 54476

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT04214067, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 12, 2026 · Synced May 9, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04214067 live on ClinicalTrials.gov.

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