Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo
Public ClinicalTrials.gov record NCT04221230. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Randomized, Double-blind, Placebo-controlled Proof of Concept Study to Evaluate the Effects of Oral BTRX-335140 (NMRA-335140) Versus Placebo in Subjects With Major Depressive Disorder
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A proof of concept (POC) study evaluating the impact of NMRA-335140 (BTRX-335140) relative to placebo on symptoms of major depressive disorder (MDD) in adult participants with MDD and symptoms of anhedonia and anxiety following 8 weeks of double-blind treatment as assessed by the HAMD-17 Scale.
Study identification
- NCT ID
- NCT04221230
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 204 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 3, 2020 (Actual)
- Primary completion
- Apr 8, 2022 (Actual)
- Completion
- Jun 23, 2022 (Actual)
- Last update posted
- May 29, 2025
2020 – 2022
United States locations
- U.S. sites
- 38
- U.S. states
- 13
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Neumora Investigator Site | Phoenix | Arizona | 85016 | — |
| Neumora Investigator Site | Bentonville | Arkansas | 72712 | — |
| Neumora Investigator Site | Little Rock | Arkansas | 72211 | — |
| Neumora Investigator Site | Bellflower | California | 90706 | — |
| Neumora Investigator Site | Culver City | California | 90230 | — |
| Neumora Investigator Site | Garden Grove | California | 92845 | — |
| Neumora Investigator Site | Glendale | California | 91206 | — |
| Neumora Investigator Site | Long Beach | California | 90807 | — |
| Neumora Investigator Site | Oakland | California | 94607 | — |
| Neumora Investigator Site | Riverside | California | 92506 | — |
| Neumora Investigator Site | San Jose | California | 95124 | — |
| Neumora Investigator Site | Santa Ana | California | 92705 | — |
| Neumora Investigator Site | Sherman Oaks | California | 91403 | — |
| Neumora Investigator Site | Torrance | California | 90502 | — |
| Neumora Investigator Site | Upland | California | 91786 | — |
| Neumora Investigator Site | Fernandina Beach | Florida | 32034 | — |
| Neumora Investigator Site | Jacksonville | Florida | 32256 | — |
| Neumora Investigator Site | Lauderhill | Florida | 33319 | — |
| Neumora Investigator Site | Miami Lakes | Florida | 33016 | — |
| Neumora Investigator Site | Orlando | Florida | 32751 | — |
| Neumora Investigator Site | Orlando | Florida | 32801 | — |
| Neumora Investigator Site | Sarasota | Florida | 34243 | — |
| Neumora Investigator Site | Atlanta | Georgia | 30328 | — |
| Neumora Investigator Site | Atlanta | Georgia | 30331 | — |
| Neumora Investigator Site | Atlanta | Georgia | 30338 | — |
| Neumora Investigator Site | Decatur | Georgia | 30030 | — |
| Neumora Investigator Site | Las Vegas | Nevada | 89102 | — |
| Neumora Investigator Site | Berlin | New Jersey | 08009 | — |
| Neumora Investigator Site | Brooklyn | New York | 11229 | — |
| Neumora Investigator Site | Jamaica | New York | 11432 | — |
| Neumora Investigator Site | New York | New York | 10036 | — |
| Neumora Investigator Site | Rochester | New York | 14618 | — |
| Neumora Investigator Site | Staten Island | New York | 10312 | — |
| Neumora Investigator Site | Dayton | Ohio | 45417 | — |
| Neumora Investigator Site | Oklahoma City | Oklahoma | 73112 | — |
| Neumora Investigator Site | Memphis | Tennessee | 38119 | — |
| Neumora Investigator Site | Wichita Falls | Texas | 76309 | — |
| Neumora Investigator Site | Clinton | Utah | 84015 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04221230, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 29, 2025 · Synced Oct 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04221230 live on ClinicalTrials.gov.