IMPact on Revascularization Outcomes of IVUS Guided Treatment of Complex Lesions and Economic Impact
Public ClinicalTrials.gov record NCT04221815. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
IMPact on Revascularization Outcomes of intraVascular Ultrasound Guided Treatment of Complex Lesions and Economic Impact (IMPROVE)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) has been shown in clinical trials, registries, and meta-analyses to reduce recurrent events after PCI. This is accomplished by improving the angiographic result with lesion and vessel assessment to guide stent selection and implantation and intravascular imaging following stent implantation to ensure an adequate treatment endpoint has been achieved. Despite extensive literature supporting the use of IVUS in PCI, utilization remains low in the United States. An increasing number of high-risk or complex lesions are being treated with PCI and we hypothesize that the impact of IVUS in these complex lesions will be of increased importance in reducing clinical adverse events while remaining cost effective.
Study identification
- NCT ID
- NCT04221815
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 3,100 participants
Conditions and interventions
Conditions
Interventions
- Eagle Eye Platinum digital IVUS catheter with optional SyncVision Device
- Resolute Onyx Drug Eluting Stent Device
- Onyx Frontier Drug Eluting Stent Device
- Onyx TruStar Drug Eluting Stent Device
- Onyx TruCor Drug Eluting Stent Device
Device
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 14, 2020 (Actual)
- Primary completion
- Sep 2026 (Estimated)
- Completion
- Sep 2027 (Estimated)
- Last update posted
- Sep 12, 2025
2020 – 2027
United States locations
- U.S. sites
- 40
- U.S. states
- 19
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northwest Medical Center | Tucson | Arizona | 85741 | — |
| Central Arkansas Veterans Healthcare System | Little Rock | Arkansas | 72205 | — |
| University of California San Deigo | La Jolla | California | 92037 | — |
| San Francisco VA Health Care System | San Francisco | California | 94121 | — |
| San Antonio Regional Hospital | Upland | California | 91786 | — |
| Medstar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| Manatee Memorial Hospital | Bradenton | Florida | 34205 | — |
| AdventHealth Orlando | Orlando | Florida | 32803 | — |
| Ascension Sacred Heart | Pensacola | Florida | 32504 | — |
| AdventHealth Sebring | Sebring | Florida | 33870 | — |
| Tampa Cardiovascular/St. Joseph's Hospital | Tampa | Florida | 33614 | — |
| Emory | Atlanta | Georgia | 30322 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Rush University Medial Center | Chicago | Illinois | 60612 | — |
| Riverside Medical Center | Kankakee | Illinois | 60901 | — |
| Carle Foundation Hospital | Urbana | Illinois | 61801 | — |
| MercyOne Iowa Heart Center | Des Moines | Iowa | 50314 | — |
| MedStar Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| MedStar Southern Maryland Hospital Center | Clinton | Maryland | 20735 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| Ascension St. John | Dearborn | Michigan | 48124 | — |
| St. Luke's Hospital of Duluth | Duluth | Minnesota | 55805 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Virtua Our Lady of Lourdes Hospital | Camden | New Jersey | 08103 | — |
| AtlantiCare Regional Medical Center | Pomona | New Jersey | 08240 | — |
| Northwell Health - South Shore University Hospital | Bay Shore | New York | 11706 | — |
| NYU Langone Hospital | Brooklyn | New York | 11220 | — |
| Northwell Health - North Shore University Hospital | Manhasset | New York | 11030 | — |
| Northwell Health - Lennox Hill Hospital | New York | New York | 10075 | — |
| St. Francis | Roslyn | New York | 11576 | — |
| Good Samaritan University Hospital | West Islip | New York | 11795 | — |
| University of North Carolina Rex Hospital | Raleigh | North Carolina | 27607 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43201 | — |
| Lehigh Valley Hospital | Allentown | Pennsylvania | 18103 | — |
| Seton Medical Center Austin | Austin | Texas | 78705 | — |
| Texas Tech University Health Sciences Center | El Paso | Texas | 79905 | — |
| Carilion Clinic | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04221815, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 12, 2025 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04221815 live on ClinicalTrials.gov.