ClinicalTrials.gov record
A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
ClinicalTrials.gov ID: NCT04241068
Public ClinicalTrials.gov record NCT04241068. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 3b Open-Label, Multicenter, Safety Study of BIIB037 (Aducanumab) in Subjects With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective is to evaluate the safety and tolerability of aducanumab over 100 weeks of treatment after a wash-out period imposed by discontinuation of feeder studies in participants who had previously received aducanumab (i.e. previously treated participants) or who had previously received placebo (i.e. treatment-naïve participants).
Study identification
- NCT ID
- NCT04241068
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,696 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2020
- Primary completion
- Jul 21, 2024
- Completion
- Jul 21, 2024
- Last update posted
- Feb 20, 2025
2020 – 2024
United States locations
- U.S. sites
- 104
- U.S. states
- 33
- U.S. cities
- 85
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Banner Alzheimer's Institute | Phoenix | Arizona | 85006 | — |
| Dignity Health | Phoenix | Arizona | 85013 | — |
| Banner Sun Health Research Institute | Sun City | Arizona | 85351 | — |
| Center for Neurosciences | Tucson | Arizona | 85718 | — |
| Neurology Center of North Orange County | Fullerton | California | 92835 | — |
| UCI MIND | Irvine | California | 92607 | — |
| University of California San Diego Medical Center | La Jolla | California | 92037 | — |
| Senior Clinical Trials, Inc. | Laguna Hills | California | 92653 | — |
| USC Keck School of Medicine | Los Angeles | California | 90033 | — |
| Mary S. Easton Center for Alzheimer's Disease Research, UCLA | Los Angeles | California | 90095 | — |
| Pacific Neuroscience Medical Group | Oxnard | California | 93030 | — |
| Stanford Hospital and Clinics | Palo Alto | California | 94304 | — |
| Anderson Clinical Research | Redlands | California | 92374 | — |
| Pacific Research Network, Inc | San Diego | California | 92103 | — |
| UCSF - Memory and Aging Center | San Francisco | California | 94143 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| California Neuroscience Research Medical Group Inc. | Sherman Oaks | California | 91403 | — |
| University of Colorado Denver | Aurora | Colorado | 80045 | — |
| IMMUNOe International Research Centers | Centennial | Colorado | 80112 | — |
| Yale University | Fairfield | Connecticut | 06824 | — |
| Invicro | New Haven | Connecticut | 06510 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06510 | — |
| Research Center for Clinical Studies, Inc. | Norwalk | Connecticut | 06851 | — |
| Georgetown University Clinical Research Unit (CRU) | Washington D.C. | District of Columbia | 20007 | — |
| JEM Research | Atlantis | Florida | 33462 | — |
| Bradenton Research Center, Inc | Bradenton | Florida | 34205 | — |
| Brain Matters Research | Delray Beach | Florida | 334405 | — |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | — |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33024 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 33462 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Miami Jewish Health System, Inc | Miami | Florida | 33180 | — |
| Renstar Medical Research | Ocala | Florida | 34470 | — |
| Accelerated Enrollment Solutions (AES) | Orlando | Florida | 32162 | — |
| Clinical Neuroscience Solutions, Inc. | Orlando | Florida | 32801 | — |
| Accelerated Enrollment Solutions (AES) | Orlando | Florida | 32806 | — |
| Palm Beach Neurological Center | Palm Beach Gardens | Florida | 33410 | — |
| Quantum Laboratories Inc. | Pompano Beach | Florida | 33064 | — |
| Axiom Clinical Research of Florida | Tampa | Florida | 33609 | — |
| Stedman Clinical Trials, LLC | Tampa | Florida | 33613 | — |
| USF Health Byrd Institute | Tampa | Florida | 33616 | — |
| Meridien Research | Tampa | Florida | 33634 | — |
| Premiere Research Institute | West Palm Beach | Florida | 33407 | — |
| Cleveland Clinic Florida - Weston | Weston | Florida | 33331 | — |
| Emory University Cognitive Neurology Clinic & ADRC | Atlanta | Georgia | 30329 | — |
| Medical Research Health and Education Foundation, Inc | Columbus | Georgia | 31909 | — |
| NeuroStudies.net, LLC | Decatur | Georgia | 30033 | — |
| Alexian Brothers Medical Center - Neuroscience Research Institute | Elk Grove Village | Illinois | 60007 | — |
| Advocate Lutheran General Hospital | Park Ridge | Illinois | 60068 | — |
| Fort Wayne Neurological Center | Fort Wayne | Indiana | 46804 | — |
| Indiana University School of Medicine | Indianapolis | Indiana | 46202 | — |
| Josephson, Wallack, Munshower Neurology, P.C. | Indianapolis | Indiana | 46256 | — |
| University of Kansas Medical Center Research Institute, Inc. | Fairway | Kansas | 66205 | — |
| Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc. | Wichita | Kansas | 67214 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| McLean Hospital | Belmont | Massachusetts | 02474 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Brigham and Women's Hospital Department of Neurology | Boston | Massachusetts | 02215 | — |
| ActivMed Practices & Research, Inc. | Methuen | Massachusetts | 01844 | — |
| Boston Center for Memory | Newton | Massachusetts | 02459 | — |
| Donald S. Marks, M.D., P.C. | Plymouth | Massachusetts | 02360 | — |
| Mayo Clinic | Rochester | Michigan | 55902 | — |
| Hattiesburg Clinic, PA | Hattiesburg | Mississippi | 39401 | — |
| Washington University | St Louis | Missouri | 63108 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health | Las Vegas | Nevada | 89106 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| ActivMed Practices & Research, Inc. | Portsmouth | New Hampshire | 03801 | — |
| Advanced Memory Research Inst. of NJ, PC | Toms River | New Jersey | 08755 | — |
| Albany Medical College | Albany | New York | 12208 | — |
| Empire Neurology, PC | Latham | New York | 12110 | — |
| New York University Medical Center PRIME | New York | New York | 10016 | — |
| Weill Cornell Medical College (WCMC) - Judith Jaffe Multiple Sclerosis Center (JJMSC) | New York | New York | 10021 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| University of Rochester | Rochester | New York | 14620 | — |
| AMC Research, LLC | Charlotte | North Carolina | 28270 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607-6010 | — |
| Gastroenterology Associates of the Piedmont | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157-1207 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Lynn Health Science Institute | Oklahoma City | Oklahoma | 73112 | — |
| Lehigh Center for Clinical Research, LLC | Allentown | Pennsylvania | 18104 | — |
| The Clinical Trial Center, LLC | Jenkintown | Pennsylvania | 19046 | — |
| Penn Memory Center | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15261 | — |
| Northeastern Pennsylvania Memory and Alzheimer's Center | Wilkes-Barre | Pennsylvania | 18705 | — |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Butler Hospital | Providence | Rhode Island | 02906 | — |
| Roper St. Francis Healthcare | Charleston | South Carolina | 29401 | — |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | — |
| Neurology Clinic, PC | Cordova | Tennessee | 38018 | — |
| Senior Adult Specialty Research | Austin | Texas | 33410 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9129 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84108 | — |
| The Memory Clinic | Bennington | Vermont | 05201 | — |
| National Clinical Research Inc.-Richmond | Richmond | Virginia | 23294 | — |
| University of Washington Medical Centre | Seattle | Washington | 98104-2499 | — |
| Kingfisher Cooperative, LLC | Spokane | Washington | 99202 | — |
| Medical College of Wisconsin, Inc. | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 193 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04241068, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 20, 2025 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04241068 live on ClinicalTrials.gov.