ClinicalTrials.gov record
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
ClinicalTrials.gov ID: NCT04255433
Public ClinicalTrials.gov record NCT04255433. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
The Effect of Tirzepatide Versus Dulaglutide on Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes (SURPASS-CVOT)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.
Study identification
- NCT ID
- NCT04255433
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 13,299 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 29, 2020 (Actual)
- Primary completion
- Jun 12, 2025 (Actual)
- Completion
- Jun 12, 2025 (Actual)
- Last update posted
- Jul 8, 2026
2020 – 2025
United States locations
- U.S. sites
- 121
- U.S. states
- 35
- U.S. cities
- 109
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Medical Center | Birmingham | Alabama | 35294-0012 | — |
| John Muir Medical Center - Concord Campus | Concord | California | 94520 | — |
| Valley Clinical Trials, Inc. | Covina | California | 91723 | — |
| AMCR Institute | Escondido | California | 92025 | — |
| Valley Research | Fresno | California | 93720 | — |
| NorCal Medical Research, Inc | Greenbrae | California | 94904 | — |
| UCSD - Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California | 92037 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Monterey Endocrine & Diabetes Institute, Inc. | Monterey | California | 93940 | — |
| Riverside University Health System - Medical Center | Moreno Valley | California | 92555 | — |
| Diabetes Associates Medical Group | Orange | California | 92868 | — |
| Pasadena Clinical Research | Pasadena | California | 91105 | — |
| LCGK Research | San Carlos | California | 94070 | — |
| Norcal Endocrinology & Internal Medicine | San Ramon | California | 94583 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Torrance | California | 90502 | — |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | — |
| CMR of Greater New Haven, LLC | Hamden | Connecticut | 06517 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Orlando Heart & Vascular Institute, LLC | Altamonte Springs | Florida | 32714 | — |
| Excel Medical Clinical Trials | Boca Raton | Florida | 33434 | — |
| Encore Medical Research | Hollywood | Florida | 33024 | — |
| East Coast Institute for Research, LLC | Jacksonville | Florida | 32204 | — |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | — |
| Accel Research Sites - St. Pete-Largo Clinical Research Unit | Largo | Florida | 33777 | — |
| Ocala Caridovascular Research | Ocala | Florida | 34474 | — |
| Cardiology Partners Clinical Research Institute - Palm Beach Gardens | Palm Beach Gardens | Florida | 33410 | — |
| Peace River Cardiovascular Center | Port Charlotte | Florida | 33952 | — |
| Professional Health Care of Pinellas | St. Petersburg | Florida | 33713 | — |
| Cardiology Partners Clinical Research Institute - Wellington | Wellington | Florida | 33449 | — |
| Clinical Research of Central Florida | Winter Haven | Florida | 33880 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Kaiser Permanente - Dutluth, GA | Duluth | Georgia | 30096 | — |
| NSC Research | Johns Creek | Georgia | 30024 | — |
| Physicians Research Associates | Lawrenceville | Georgia | 30045 | — |
| East Coast Institute for Research at The Jones Center | Macon | Georgia | 31210 | — |
| Atlanta Heart Specialists | Tucker | Georgia | 30084 | — |
| East-West Medical Research Institute | Honolulu | Hawaii | 96814 | — |
| VA Pacific Islands Health Care System | Honolulu | Hawaii | 96819 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Rocky Mountain Clinical Research | Idaho Falls | Idaho | 83404 | — |
| Northwest Heart Clinical Research | Arlington Heights | Illinois | 60005 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Clinical Investigation Specialists | Gurnee | Illinois | 60031 | — |
| Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative | Springfield | Illinois | 62711 | — |
| University of Iowa | Iowa City | Iowa | 52242 | — |
| Iowa Diabetes and Endocrinology Research Center | West Des Moines | Iowa | 50266 | — |
| The University of Kansas - Clinical Research Center | Fairway | Kansas | 66205 | — |
| Cotton O'Neil Diabetes & Endocrinology | Topeka | Kansas | 66606 | — |
| Cotton O'Neil Mulvane | Topeka | Kansas | 66606 | — |
| Qualmedica Research | Bowling Green | Kentucky | 42101 | — |
| L-MARC Research Center | Louisville | Kentucky | 40213 | — |
| Qualmedica Research, LLC | Owensboro | Kentucky | 42301 | — |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | — |
| MedStar Health Research Institute (MedStar Physician Based Research Network) | Hyattsville | Maryland | 20782 | — |
| MD Medical Research | Oxon Hill | Maryland | 20745 | — |
| Endocrine and Metabolic Consultants | Rockville | Maryland | 20852 | — |
| Brigham and Women's Hospital Diabetes Program | Boston | Massachusetts | 02115 | — |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Infinity Medical Research | North Dartmouth | Massachusetts | 02747 | — |
| Arcturus Healthcare , PLC, Troy Internal Medicine Research Division | Troy | Michigan | 48098 | — |
| St. John's Hospital | Edina | Minnesota | 55435 | — |
| M Health Fairview St. John's Hospital | Maplewood | Minnesota | 55109 | — |
| CentraCare Heart & Vascular Center | Saint Cloud | Minnesota | 56303 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| Clinvest Research LLC | Springfield | Missouri | 65807 | — |
| Mercy Research - Smith Glynn Callaway | Springfield | Missouri | 65807 | — |
| Billings Clinic | Billings | Montana | 59101 | — |
| Mercury Street Medical Group, PLLC | Butte | Montana | 59701 | — |
| VA Nebraska-Western Iowa Health Care System | Omaha | Nebraska | 68105 | — |
| University Of Nebraska Medical Center | Omaha | Nebraska | 68198-4130 | — |
| Palm Research Center Tenaya | Las Vegas | Nevada | 89128 | — |
| Palm Research Center Sunset | Las Vegas | Nevada | 89148 | — |
| Southern Nh Diabetes and Endocrinology | Nashua | New Hampshire | 03060 | — |
| Albany Medical College, Division of Community Endocrinology | Albany | New York | 12203 | — |
| Great Lakes Medical Research, LLC | Westfield | New York | 14787 | — |
| Atrium Health - Department of Family Medicine Research | Charlotte | North Carolina | 28207 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| PMG Research Inc., d/b/a PMG of Piedmont Healthcare | Mooresville | North Carolina | 28117 | — |
| Accellacare - Wilmington | Wilmington | North Carolina | 24801 | — |
| Lillestol Research | Fargo | North Dakota | 58104 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Alliance for Multispecialty Research, LLC | Norman | Oklahoma | 73069 | — |
| Heritage Valley Medical Group, Inc. | Beaver | Pennsylvania | 15009 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Decpa, Llc | Feasterville | Pennsylvania | 19053 | — |
| Thomas Jefferson University - Clinical Research Institute | Philadelphia | Pennsylvania | 19107 | — |
| Northeast Endocrine Metabolic Associates | Philadelphia | Pennsylvania | 19114 | — |
| Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18) | Pittsburgh | Pennsylvania | 15236 | — |
| Cardiology Consultants of Philadelphia Yardley | Yardley | Pennsylvania | 19067 | — |
| Ralph H. Johnson VA Medical Center | Charleston | South Carolina | 29401 | — |
| Tribe Clinical Research, LLC | Greenville | South Carolina | 29607 | — |
| Accellacare - Mt Pleasant | Mt. Pleasant | South Carolina | 29464 | — |
| Monument Health Rapid City Hospital | Rapid City | South Dakota | 57701 | — |
| Holston Medical Group | Bristol | Tennessee | 37620 | — |
| PMG Research, Inc. d/b/a PMG Research of Knoxville | Knoxville | Tennessee | 37938 | — |
| Endocrine Clinic | Memphis | Tennessee | 38119 | — |
| Private Practice - Dr. Osvaldo A. Brusco | Corpus Christi | Texas | 78414 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| Research Institute of Dallas | Dallas | Texas | 75231 | — |
| Texas Health Physicians Group | Dallas | Texas | 75231 | — |
| Galenos Research | Dallas | Texas | 75251 | — |
| Academy of Diabetes, Thyroid and Endocrine | El Paso | Texas | 79935 | — |
| Diabetes and Thyroid Center of Ft. Worth | Fort Worth | Texas | 76132 | — |
| Northwest Houston Cardiology - Cypress | Houston | Texas | 77070 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| North Hills Family Medicine/North Hills Medical Research | North Richland Hills | Texas | 76180 | — |
| Audie L Murphy VA Hospital | San Antonio | Texas | 75231 | — |
| Consano Clinical Research, LLC | Shavano Park | Texas | 78231 | — |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | — |
| Physicians' Research Options | Draper | Utah | 84020 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Alpine Medical Group | Salt Lake City | Utah | 84102 | — |
| Kalo Clinical Research | West Valley City | Utah | 84120 | — |
| Virginia Heart | Falls Church | Virginia | 22042 | — |
| MultiCare Good Samaritan Hospital | Puyallup | Washington | 98372 | — |
| VA Puget Sound Health Care System | Seattle | Washington | 98108 | — |
| Multicare Institute for Research and Innovation | Spokane | Washington | 99202 | — |
| Central Washington Health Services Association d/b/a Confluence Health | Wenatchee | Washington | 98801 | — |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 514 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04255433, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 8, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04255433 live on ClinicalTrials.gov.