A Study of Pevonedistat and Venetoclax Combined With Azacitidine to Treat Acute Myeloid Leukemia (AML) in Adults Unable to Receive Intensive Chemotherapy
Public ClinicalTrials.gov record NCT04266795. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label, Controlled, Phase 2 Study of Pevonedistat, Venetoclax, and Azacitidine Versus Venetoclax Plus Azacitidine in Adults With Newly Diagnosed Acute Myeloid Leukemia Who Are Unfit for Intensive Chemotherapy
Study identification
- NCT ID
- NCT04266795
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Takeda
- Industry
- Enrollment
- 164 participants
Conditions and interventions
Conditions
Interventions
- Azacitidine Drug
- Pevonedistat Drug
- Venetoclax Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 12, 2020
- Primary completion
- Sep 5, 2022
- Completion
- Oct 5, 2025
- Last update posted
- Oct 20, 2025
2020 – 2025
United States locations
- U.S. sites
- 23
- U.S. states
- 18
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92093 | — |
| UC Irvine Medical Center | Orange | California | 92868 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| AdventHealth (Florida Hospital) - Transplant Institute | Orlando | Florida | 32804 | — |
| Norton Cancer Institute - Suburban | Louisville | Kentucky | 40207 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| HCA Midwest Health - SCRI - PPDS | Kansas City | Missouri | 64132 | — |
| Northwell Health Cancer Institute | Lake Success | New York | 11042 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029-6574 | — |
| Stony Brook Medicine | Stony Brook | New York | 11794 | — |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514-4221 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| The University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | — |
| Houston Methodist Cancer Center | Houston | Texas | 77030 | — |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410 | — |
| Intermountain LDS Hospital | Salt Lake City | Utah | 84143 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 34 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04266795, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2025 · Synced May 11, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04266795 live on ClinicalTrials.gov.