ClinicalTrials.gov record
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
ClinicalTrials.gov ID: NCT04269902
Public ClinicalTrials.gov record NCT04269902. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Phase III Study of Early Intervention With Venetoclax and Obinutuzumab Versus Delayed Therapy With Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): EVOLVE CLL/SLL Study
Study identification
- NCT ID
- NCT04269902
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- National Cancer Institute (NCI)
- NIH
- Enrollment
- 247 participants
Conditions and interventions
Conditions
Not listed
Interventions
Not listed
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2021
- Primary completion
- Sep 30, 2028
- Completion
- Sep 30, 2028
- Last update posted
- May 18, 2026
2021 – 2028
United States locations
- U.S. sites
- 195
- U.S. states
- 13
- U.S. cities
- 139
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | Active, not recruiting |
| Anchorage Associates in Radiation Medicine | Anchorage | Alaska | 98508 | Suspended |
| Anchorage Radiation Therapy Center | Anchorage | Alaska | 99504 | Suspended |
| Alaska Breast Care and Surgery LLC | Anchorage | Alaska | 99508 | Suspended |
| Alaska Oncology and Hematology LLC | Anchorage | Alaska | 99508 | Suspended |
| Alaska Women's Cancer Care | Anchorage | Alaska | 99508 | Suspended |
| Anchorage Oncology Centre | Anchorage | Alaska | 99508 | Suspended |
| Katmai Oncology Group | Anchorage | Alaska | 99508 | Suspended |
| Providence Alaska Medical Center | Anchorage | Alaska | 99508 | Suspended |
| Fairbanks Memorial Hospital | Fairbanks | Alaska | 99701 | Suspended |
| Cancer Center at Saint Joseph's | Phoenix | Arizona | 85004 | Active, not recruiting |
| Banner University Medical Center - Tucson | Tucson | Arizona | 85719 | Recruiting |
| University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | Recruiting |
| Mercy Hospital Fort Smith | Fort Smith | Arkansas | 72903 | Suspended |
| CHI Saint Vincent Cancer Center Hot Springs | Hot Springs | Arkansas | 71913 | Suspended |
| NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro | Arkansas | 72401 | Recruiting |
| Kaiser Permanente-Anaheim | Anaheim | California | 92806 | Recruiting |
| Mission Hope Medical Oncology - Arroyo Grande | Arroyo Grande | California | 93420 | Active, not recruiting |
| Kaiser Permanente-Baldwin Park | Baldwin Park | California | 91706 | Recruiting |
| Kaiser Permanente-Bellflower | Bellflower | California | 90706 | Recruiting |
| Providence Saint Joseph Medical Center/Disney Family Cancer Center | Burbank | California | 91505 | Suspended |
| Marshall Cancer Center | Cameron Park | California | 95682 | Recruiting |
| Mercy Cancer Center - Carmichael | Carmichael | California | 95608 | Active, not recruiting |
| Mercy San Juan Medical Center | Carmichael | California | 95608 | Active, not recruiting |
| UC Irvine Health Cancer Center-Newport | Costa Mesa | California | 92627 | Recruiting |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | Recruiting |
| Mercy Cancer Center - Elk Grove | Elk Grove | California | 95758 | Active, not recruiting |
| Kaiser Permanente-Fontana | Fontana | California | 92335 | Recruiting |
| Kaiser Permanente South Bay | Harbor City | California | 90710 | Recruiting |
| City of Hope Seacliff | Huntington Beach | California | 92648 | Recruiting |
| UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | Recruiting |
| City of Hope at Irvine Lennar | Irvine | California | 92618 | Recruiting |
| Kaiser Permanente-Irvine | Irvine | California | 92618 | Recruiting |
| UCI Health Laguna Hills | Laguna Hills | California | 92653 | Recruiting |
| City of Hope Antelope Valley | Lancaster | California | 93534 | Recruiting |
| City of Hope at Long Beach Elm | Long Beach | California | 90813 | Recruiting |
| Tibor Rubin VA Medical Center | Long Beach | California | 90822 | Active, not recruiting |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | Recruiting |
| Kaiser Permanente West Los Angeles | Los Angeles | California | 90034 | Recruiting |
| Fremont - Rideout Cancer Center | Marysville | California | 95901 | Recruiting |
| City of Hope Newport Beach | Newport Beach | California | 92660 | Recruiting |
| Kaiser Permanente-Ontario | Ontario | California | 91761 | Recruiting |
| UC Irvine Health/Chao Family Comprehensive Cancer Center | Orange | California | 92868 | Recruiting |
| Stanford Cancer Institute Palo Alto | Palo Alto | California | 94304 | Active, not recruiting |
| Kaiser Permanente - Panorama City | Panorama City | California | 91402 | Recruiting |
| Kaiser Permanente-Riverside | Riverside | California | 92505 | Recruiting |
| Mercy Cancer Center - Rocklin | Rocklin | California | 95765 | Active, not recruiting |
| Mercy Cancer Center - Sacramento | Sacramento | California | 95816 | Active, not recruiting |
| University of California Davis Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| Kaiser Permanente-San Diego Zion | San Diego | California | 92120 | Recruiting |
| Pacific Central Coast Health Center-San Luis Obispo | San Luis Obispo | California | 93401 | Active, not recruiting |
| Kaiser Permanente-San Marcos | San Marcos | California | 92078 | Recruiting |
| Mission Hope Medical Oncology - Santa Maria | Santa Maria | California | 93444 | Active, not recruiting |
| City of Hope South Pasadena | South Pasadena | California | 91030 | Recruiting |
| City of Hope South Bay | Torrance | California | 90503 | Recruiting |
| City of Hope Upland | Upland | California | 91786 | Recruiting |
| Woodland Memorial Hospital | Woodland | California | 95695 | Active, not recruiting |
| Kaiser Permanente-Woodland Hills | Woodland Hills | California | 91367 | Recruiting |
| Rocky Mountain Cancer Centers-Aurora | Aurora | Colorado | 80012 | Active, not recruiting |
| The Medical Center of Aurora | Aurora | Colorado | 80012 | Suspended |
| Boulder Community Foothills Hospital | Boulder | Colorado | 80303 | Active, not recruiting |
| Rocky Mountain Cancer Centers-Boulder | Boulder | Colorado | 80304 | Active, not recruiting |
| Rocky Mountain Cancer Centers - Centennial | Centennial | Colorado | 80112 | Active, not recruiting |
| Penrose-Saint Francis Healthcare | Colorado Springs | Colorado | 80907 | Active, not recruiting |
| Rocky Mountain Cancer Centers-Penrose | Colorado Springs | Colorado | 80907 | Active, not recruiting |
| Cancer Center of Colorado at Sloan's Lake | Denver | Colorado | 80204 | Suspended |
| National Jewish Health-Main Campus | Denver | Colorado | 80206 | Suspended |
| The Women's Imaging Center | Denver | Colorado | 80209 | Active, not recruiting |
| AdventHealth Porter | Denver | Colorado | 80210 | Suspended |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | Active, not recruiting |
| Presbyterian - Saint Lukes Medical Center - Health One | Denver | Colorado | 80218 | Active, not recruiting |
| Rocky Mountain Cancer Centers-Midtown | Denver | Colorado | 80218 | Active, not recruiting |
| Saint Joseph Hospital - Cancer Centers of Colorado | Denver | Colorado | 80218 | Suspended |
| Rocky Mountain Cancer Centers-Rose | Denver | Colorado | 80220 | Active, not recruiting |
| Rose Medical Center | Denver | Colorado | 80220 | Suspended |
| Western Surgical Care | Denver | Colorado | 80220 | Active, not recruiting |
| CommonSpirit Cancer Center Mercy | Durango | Colorado | 81301 | Active, not recruiting |
| Mercy Medical Center | Durango | Colorado | 81301 | Active, not recruiting |
| Mountain Blue Cancer Care Center - Swedish | Englewood | Colorado | 80113 | Active, not recruiting |
| Rocky Mountain Cancer Centers - Swedish | Englewood | Colorado | 80113 | Active, not recruiting |
| Swedish Medical Center | Englewood | Colorado | 80113 | Suspended |
| The Melanoma and Skin Cancer Institute | Englewood | Colorado | 80113 | Active, not recruiting |
| National Jewish Health-Western Hematology Oncology | Golden | Colorado | 80401 | Suspended |
| Saint Mary's Hospital and Regional Medical Center | Grand Junction | Colorado | 81501 | Suspended |
| Grand Valley Oncology | Grand Junction | Colorado | 81505 | Recruiting |
| Banner North Colorado Medical Center | Greeley | Colorado | 80631 | Suspended |
| Good Samaritan Hospital - Cancer Centers of Colorado | Lafayette | Colorado | 80026 | Suspended |
| Rocky Mountain Cancer Centers-Lakewood | Lakewood | Colorado | 80228 | Active, not recruiting |
| Saint Anthony Hospital | Lakewood | Colorado | 80228 | Active, not recruiting |
| Rocky Mountain Cancer Centers-Littleton | Littleton | Colorado | 80120 | Active, not recruiting |
| AdventHealth Littleton | Littleton | Colorado | 80122 | Suspended |
| Rocky Mountain Cancer Centers-Sky Ridge | Lone Tree | Colorado | 80124 | Active, not recruiting |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | Suspended |
| Longmont United Hospital | Longmont | Colorado | 80501 | Active, not recruiting |
| Rocky Mountain Cancer Centers-Longmont | Longmont | Colorado | 80501 | Active, not recruiting |
| Banner North Colorado Medical Center - Loveland Campus | Loveland | Colorado | 80539 | Suspended |
| AdventHealth Parker | Parker | Colorado | 80138 | Suspended |
| Saint Mary Corwin Medical Center | Pueblo | Colorado | 81004 | Active, not recruiting |
| National Jewish Health-Northern Hematology Oncology | Thornton | Colorado | 80260 | Suspended |
| Rocky Mountain Cancer Centers-Thornton | Thornton | Colorado | 80260 | Active, not recruiting |
| Beebe Medical Center | Lewes | Delaware | 19958 | Suspended |
| Beebe South Coastal Health Campus | Millville | Delaware | 19967 | Recruiting |
| Delaware Clinical and Laboratory Physicians PA | Newark | Delaware | 19713 | Suspended |
| Helen F Graham Cancer Center | Newark | Delaware | 19713 | Recruiting |
| Medical Oncology Hematology Consultants PA | Newark | Delaware | 19713 | Recruiting |
| Christiana Care Health System-Christiana Hospital | Newark | Delaware | 19718 | Suspended |
| Beebe Health Campus | Rehoboth Beach | Delaware | 19971 | Recruiting |
| TidalHealth Nanticoke / Allen Cancer Center | Seaford | Delaware | 19973 | Suspended |
| Christiana Care Health System-Wilmington Hospital | Wilmington | Delaware | 19801 | Suspended |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | Active, not recruiting |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | Recruiting |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | Recruiting |
| Sacred Heart Hospital | Pensacola | Florida | 32504 | Active, not recruiting |
| Saint Alphonsus Cancer Care Center-Boise | Boise | Idaho | 83706 | Recruiting |
| Saint Luke's Cancer Institute - Boise | Boise | Idaho | 83712 | Suspended |
| Saint Alphonsus Cancer Care Center-Caldwell | Caldwell | Idaho | 83605 | Recruiting |
| Kootenai Health - Coeur d'Alene | Coeur d'Alene | Idaho | 83814 | Recruiting |
| Walter Knox Memorial Hospital | Emmett | Idaho | 83617 | Suspended |
| Saint Luke's Cancer Institute - Fruitland | Fruitland | Idaho | 83619 | Suspended |
| Idaho Urologic Institute-Meridian | Meridian | Idaho | 83642 | Suspended |
| Saint Luke's Cancer Institute - Meridian | Meridian | Idaho | 83642 | Suspended |
| Saint Alphonsus Cancer Care Center-Nampa | Nampa | Idaho | 83687 | Recruiting |
| Saint Luke's Cancer Institute - Nampa | Nampa | Idaho | 83687 | Suspended |
| Kootenai Clinic Cancer Services - Post Falls | Post Falls | Idaho | 83854 | Recruiting |
| Kootenai Clinic Cancer Services - Sandpoint | Sandpoint | Idaho | 83864 | Recruiting |
| Saint Luke's Cancer Institute - Twin Falls | Twin Falls | Idaho | 83301 | Suspended |
| OSF Saint Anthony's Health Center | Alton | Illinois | 62002 | Suspended |
| Rush-Copley Medical Center | Aurora | Illinois | 60504 | Recruiting |
| Illinois CancerCare-Bloomington | Bloomington | Illinois | 61704 | Active, not recruiting |
| Loyola Center for Health at Burr Ridge | Burr Ridge | Illinois | 60527 | Suspended |
| Illinois CancerCare-Canton | Canton | Illinois | 61520 | Active, not recruiting |
| Memorial Hospital of Carbondale | Carbondale | Illinois | 62902 | Suspended |
| SIH Cancer Institute | Carterville | Illinois | 62918 | Suspended |
| Illinois CancerCare-Carthage | Carthage | Illinois | 62321 | Active, not recruiting |
| Centralia Oncology Clinic | Centralia | Illinois | 62801 | Suspended |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | Recruiting |
| Carle at The Riverfront | Danville | Illinois | 61832 | Recruiting |
| Northwestern Medicine Cancer Center Kishwaukee | DeKalb | Illinois | 60115 | Recruiting |
| Cancer Care Specialists of Illinois - Decatur | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Suspended |
| Illinois CancerCare-Dixon | Dixon | Illinois | 61021 | Active, not recruiting |
| Carle Physician Group-Effingham | Effingham | Illinois | 62401 | Recruiting |
| Crossroads Cancer Center | Effingham | Illinois | 62401 | Recruiting |
| Elmhurst Memorial Hospital | Elmhurst | Illinois | 60126 | Recruiting |
| Illinois CancerCare-Eureka | Eureka | Illinois | 61530 | Active, not recruiting |
| NorthShore University HealthSystem-Evanston Hospital | Evanston | Illinois | 60201 | Recruiting |
| Illinois CancerCare-Galesburg | Galesburg | Illinois | 61401 | Active, not recruiting |
| Western Illinois Cancer Treatment Center | Galesburg | Illinois | 61401 | Suspended |
| Northwestern Medicine Cancer Center Delnor | Geneva | Illinois | 60134 | Recruiting |
| NorthShore University HealthSystem-Glenbrook Hospital | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Glenview Outpatient Center | Glenview | Illinois | 60026 | Recruiting |
| Northwestern Medicine Grayslake Outpatient Center | Grayslake | Illinois | 60030 | Recruiting |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | Recruiting |
| NorthShore University HealthSystem-Highland Park Hospital | Highland Park | Illinois | 60035 | Recruiting |
| Loyola Medicine Homer Glen | Homer Glen | Illinois | 60491 | Suspended |
| Illinois CancerCare-Kewanee Clinic | Kewanee | Illinois | 61443 | Active, not recruiting |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | Recruiting |
| Illinois CancerCare-Macomb | Macomb | Illinois | 61455 | Active, not recruiting |
| Carle Physician Group-Mattoon/Charleston | Mattoon | Illinois | 61938 | Recruiting |
| Loyola University Medical Center | Maywood | Illinois | 60153 | Recruiting |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois | 60160 | Suspended |
| SSM Health Good Samaritan | Mount Vernon | Illinois | 62864 | Recruiting |
| Edward Hospital/Cancer Center | Naperville | Illinois | 60540 | Recruiting |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | Recruiting |
| Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | Recruiting |
| Illinois CancerCare-Ottawa Clinic | Ottawa | Illinois | 61350 | Active, not recruiting |
| Illinois CancerCare-Pekin | Pekin | Illinois | 61554 | Active, not recruiting |
| Illinois CancerCare-Peoria | Peoria | Illinois | 61615 | Active, not recruiting |
| Methodist Medical Center of Illinois | Peoria | Illinois | 61636 | Suspended |
| Illinois CancerCare-Peru | Peru | Illinois | 61354 | Active, not recruiting |
| Valley Radiation Oncology | Peru | Illinois | 61354 | Suspended |
| Edward Hospital/Cancer Center?Plainfield | Plainfield | Illinois | 60585 | Recruiting |
| Illinois CancerCare-Princeton | Princeton | Illinois | 61356 | Active, not recruiting |
| UW Health Carbone Cancer Center Rockford | Rockford | Illinois | 61114 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Springfield Clinic | Springfield | Illinois | 62702 | Recruiting |
| Springfield Memorial Hospital | Springfield | Illinois | 62781 | Suspended |
| Carle Cancer Center | Urbana | Illinois | 61801 | Recruiting |
| The Carle Foundation Hospital | Urbana | Illinois | 61801 | Suspended |
| Northwestern Medicine Cancer Center Warrenville | Warrenville | Illinois | 60555 | Recruiting |
| Illinois CancerCare - Washington | Washington | Illinois | 61571 | Active, not recruiting |
| Rush-Copley Healthcare Center | Yorkville | Illinois | 60560 | Recruiting |
| UChicago Medicine Northwest Indiana | Crown Point | Indiana | 46307 | Recruiting |
| Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| Reid Health | Richmond | Indiana | 47374 | Active, not recruiting |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | Recruiting |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | Recruiting |
| UI Health Care Mission Cancer and Blood - Ankeny Clinic | Ankeny | Iowa | 50023 | Recruiting |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | Suspended |
| Saint Anthony Regional Hospital | Carroll | Iowa | 51401 | Suspended |
| Physicians' Clinic of Iowa PC | Cedar Rapids | Iowa | 52402 | Recruiting |
| Mercy Cancer Center-West Lakes | Clive | Iowa | 50325 | Suspended |
| UI Health Care Mission Cancer and Blood - West Des Moines Clinic | Clive | Iowa | 50325 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04269902, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04269902 live on ClinicalTrials.gov.