Acetaminophen and Ascorbate in Sepsis: Targeted Therapy to Enhance Recovery
Public ClinicalTrials.gov record NCT04291508. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Prospective multi-center phase 2b randomized placebo-controlled double-blinded interventional platform trial of two different pharmacologic therapies (intravenous Vitamin C or intravenous Acetaminophen) for patients with sepsis-induced hypotension or respiratory failure.
Study identification
- NCT ID
- NCT04291508
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 488 participants
Conditions and interventions
Interventions
- Intravenous Acetaminophen (room temperature) Drug
- Intravenous Vitamin C (refrigerated) Drug
- 5% Dextrose (room temperature) Drug
- 5% Dextrose refrigerated Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 13, 2021 (Actual)
- Primary completion
- Apr 27, 2023 (Actual)
- Completion
- Jul 27, 2023 (Actual)
- Last update posted
- Sep 27, 2024
2021 – 2023
United States locations
- U.S. sites
- 41
- U.S. states
- 21
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Medical Center | Birmingham | Alabama | 35249 | — |
| University of Arizona | Tucson | Arizona | 85721 | — |
| UCSF Fresno | Fresno | California | 93701 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| UCSF Medical Center | San Francisco | California | 94143 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Denver Health Medical Center | Denver | Colorado | 80204 | — |
| University Medical Center | New Orleans | Louisiana | 70112 | — |
| Maine Medical Center | Portland | Maine | 04102 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02115 | — |
| Baystate Medical Center | Springfield | Massachusetts | 01199 | — |
| University of Michigan Medical Center | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Medical Center | Detroit | Michigan | 48025 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Mt. Sinai Hospital | New York | New York | 10029 | — |
| Montefiore Medical Center-Weiler | The Bronx | New York | 10461 | — |
| Montefiore Medical Center-Moses | The Bronx | New York | 10467 | — |
| Carolinas Medical Center | Charlotte | North Carolina | 28204 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| UPMC Presbyterian/Mercy/Shadyside/Magee | Pittsburgh | Pennsylvania | 15261 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37221 | — |
| University of Texas Health Science Center | Houston | Texas | 77030 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| University of Utah Hospital | Salt Lake City | Utah | 84132 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | — |
| Sentara/EVMS | Norfolk | Virginia | 23507 | — |
| VCU Medical Center | Richmond | Virginia | 23298 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Swedish Hospital First Hill | Seattle | Washington | 98122 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04291508, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 27, 2024 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04291508 live on ClinicalTrials.gov.