HEALEY ALS Platform Trial - Master Protocol

ClinicalTrials.gov ID: NCT04297683

Public ClinicalTrials.gov record NCT04297683. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 10, 2026, 4:00 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

HEALEY ALS Platform Trial

Study identification

NCT ID: NCT04297683
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Merit E. Cudkowicz, MD; Other
Enrollment: 1,500 participants

Conditions and interventions

Conditions

Amyotrophic Lateral Sclerosis

Interventions

ABBV-CLS-7262 Drug
CNM-Au8 Drug
DNL343 Drug
NUZ-001 Drug
Pridopidine Drug
SLS-005 Trehalose Drug
Verdiperstat Drug
Zilucoplan Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 13, 2020
Primary completion: Jun 30, 2027
Completion: Jul 31, 2028
Last update posted: May 7, 2026

2020 – 2028

United States locations

U.S. sites: 78
U.S. states: 34
U.S. cities: 67

Facility	City	State	ZIP	Site status
Barrow Neurological Institute	Phoenix	Arizona	85013	Recruiting
Mayo Clinic Scottsdale	Scottsdale	Arizona	85259	Recruiting
University of Arkansas for Medical Sciences	Little Rock	Arkansas	72205	Recruiting
Loma Linda University Health	Loma Linda	California	92354	Active, not recruiting
Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	90027	Active, not recruiting
University of Southern California	Los Angeles	California	90033	Recruiting
Cedars-Sinai Medical Center	Los Angeles	California	90048	Recruiting
University of California, Irvine	Orange	California	92868	Active, not recruiting
Forbes Norris MDA/ALS Research Center, California Pacific Medical Center	San Francisco	California	94115	Recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Hospital for Special Care	New Britain	Connecticut	06053	Recruiting
Yale University	New Haven	Connecticut	06519	Recruiting
Georgetown University	Washington D.C.	District of Columbia	20007	Recruiting
George Washington University	Washington D.C.	District of Columbia	20037	Recruiting
Nova Southeastern University	Davie	Florida	33024	Recruiting
University of Florida	Gainesville	Florida	32610	Active, not recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Active, not recruiting
University of Miami	Miami	Florida	33136	Active, not recruiting
University of South Florida	Tampa	Florida	33612	Recruiting
Augusta University	Augusta	Georgia	30912	Active, not recruiting
Saint Alphonsus Regional Medical Center	Boise	Idaho	83704	Active, not recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Chicago	Chicago	Illinois	60637	Active, not recruiting
Indiana University Health	Indianapolis	Indiana	46202	Recruiting
University of Iowa Hospitals and Clinics	Iowa City	Iowa	52242	Recruiting
University of Kansas Medical Center	Fairway	Kansas	66205	Recruiting
University of Kentucky	Lexington	Kentucky	40536	Active, not recruiting
Ochsner Health System	New Orleans	Louisiana	70115	Active, not recruiting
Johns Hopkins University	Baltimore	Maryland	21205	Active, not recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Recruiting
University of Massachusetts Medical School	North Worcester	Massachusetts	01655	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Henry Ford Health System	Detroit	Michigan	48202	Recruiting
Spectrum Health/Corewell Health	Grand Rapids	Michigan	49525	Recruiting
Essentia Health	Duluth	Minnesota	55805	Recruiting
University of Minnesota Medical School	Minneapolis	Minnesota	55455	Recruiting
Mayo Clinic - Rochester	Rochester	Minnesota	55902	Recruiting
University of Missouri Health Care	Columbia	Missouri	65212	Recruiting
Saint Louis University	St Louis	Missouri	63104	Recruiting
Washington University School of Medicine	St Louis	Missouri	63110	Recruiting
Neurology Associates, P.C./Somnos Clinical Research	Lincoln	Nebraska	68506	Active, not recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Active, not recruiting
Dent Neurologic Institute	Amherst	New York	14226	Recruiting
Mount Sinai	New York	New York	10003	Recruiting
Columbia University	New York	New York	10032	Recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Stony Brook University Hospital	Stony Brook	New York	11794	Recruiting
SUNY Upstate	Syracuse	New York	13202	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Active, not recruiting
Atrium Health	Charlotte	North Carolina	28207	Recruiting
Duke University	Durham	North Carolina	27702	Recruiting
Wake Forest Health Science	Winston-Salem	North Carolina	27157	Recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
The Ohio State University	Columbus	Ohio	43221	Recruiting
OhioHealth Research Institute	Westerville	Ohio	43082	Recruiting
Providence Brain and Spine Institute ALS Center	Portland	Oregon	97213	Active, not recruiting
Lehigh Valley Health Network	Allentown	Pennsylvania	18103	Recruiting
Penn State Hershey	Hershey	Pennsylvania	17033	Recruiting
Jefferson Weinberg ALS Center, Thomas Jefferson University	Philadelphia	Pennsylvania	19107	Recruiting
University of Pennsylvania	Philadelphia	Pennsylvania	19107	Recruiting
Lewis Katz School of Medicine at Temple University	Philadelphia	Pennsylvania	19140	Recruiting
University of Pittsburg Medical Center	Pittsburgh	Pennsylvania	15232	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Austin Neuromuscular Clinic	Austin	Texas	78759	Recruiting
Texas Neurology	Dallas	Texas	75214	Recruiting
Houston Methodist	Houston	Texas	77030	Active, not recruiting
UTHSCSA	San Antonio	Texas	78229	Active, not recruiting
University of Utah	Salt Lake City	Utah	84132	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Recruiting
Virginia Commonwealth University	Henrico	Virginia	23233	Active, not recruiting
Swedish Medical Center	Seattle	Washington	98122	Recruiting
University of Washington	Seattle	Washington	98195	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04297683, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 7, 2026 · Synced May 10, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04297683 live on ClinicalTrials.gov.

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