Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial
Public ClinicalTrials.gov record NCT04300920. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative decline in lung function \[10% relative decline in forced vital capacity (FVC), first respiratory hospitalization, lung transplantation, or all-cause mortality\] The secondary objectives will be to examine the effect of NAC on the components of the primary composite endpoint, the rates of clinical events, change in physiology, change in health status, and change in respiratory symptoms.
Study identification
- NCT ID
- NCT04300920
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 202 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2020
- Primary completion
- Mar 1, 2026
- Completion
- Mar 1, 2026
- Last update posted
- Mar 19, 2026
2020 – 2026
United States locations
- U.S. sites
- 25
- U.S. states
- 20
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85724 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Stanford University | Stanford | California | 94305 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Piedmont Healthcare | Austell | Georgia | 30106 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Loyola University | Maywood | Illinois | 60153 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Weill Cornell Medicine | New York | New York | 10016 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Ohio State University | Columbus | Ohio | 43221 | — |
| Temple University | Philadelphia | Pennsylvania | 19140 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Lisa Lancaster | Nashville | Tennessee | 37204 | — |
| University of Texas Southwestern | Dallas | Texas | 75390 | — |
| University of Texas Health San Antonio | San Antonio | Texas | 78229 | — |
| University of Utah Health | Salt Lake City | Utah | 84108 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| University of Washington | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04300920, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 19, 2026 · Synced Sep 23, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04300920 live on ClinicalTrials.gov.