Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection (PRECISIONS) Trial

ClinicalTrials.gov ID: NCT04300920

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Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to compare the effect of n-acetylcysteine (NAC) plus standard care with matched placebo plus standard of care in patients diagnosed with idiopathic pulmonary fibrosis (IPF) who have the TOLLIP rs3750920 TT genotype. The study will compare the time to a composite endpoint of relative decline in lung function \[10% relative decline in forced vital capacity (FVC), first respiratory hospitalization, lung transplantation, or all-cause mortality\] The secondary objectives will be to examine the effect of NAC on the components of the primary composite endpoint, the rates of clinical events, change in physiology, change in health status, and change in respiratory symptoms.

Study identification

NCT ID: NCT04300920
Recruitment status: Completed
Study type: Interventional
Phase: Phase 3
Lead sponsor: Fernando J Martinez; Other
Enrollment: 202 participants

Conditions and interventions

Conditions

Idiopathic Pulmonary Fibrosis

Interventions

N-acetyl cysteine Drug
Placebo Drug

Drug

Eligibility (public fields only)

Age range: 40 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 17, 2020 (Actual)
Primary completion: Mar 2, 2026 (Actual)
Completion: Mar 2, 2026 (Actual)
Last update posted: Mar 20, 2026

2020 – 2026

United States locations

U.S. sites: 25
U.S. states: 20
U.S. cities: 25

Facility	City	State	ZIP	Site status
University of Arizona	Tucson	Arizona	85724	—
University of Southern California	Los Angeles	California	90033	—
Stanford University	Stanford	California	94305	—
University of Colorado	Aurora	Colorado	80045	—
Piedmont Healthcare	Austell	Georgia	30106	—
University of Chicago	Chicago	Illinois	60637	—
Loyola University	Maywood	Illinois	60153	—
Indiana University	Indianapolis	Indiana	46202	—
University of Kansas Medical Center	Kansas City	Kansas	66160	—
Tulane University	New Orleans	Louisiana	70112	—
Massachusetts General Hospital	Boston	Massachusetts	02114	—
University of Michigan	Ann Arbor	Michigan	48109	—
University of Minnesota	Minneapolis	Minnesota	55455	—
Mayo Clinic	Rochester	Minnesota	55905	—
Weill Cornell Medicine	New York	New York	10016	—
University of Rochester	Rochester	New York	14642	—
Ohio State University	Columbus	Ohio	43221	—
Temple University	Philadelphia	Pennsylvania	19140	—
Medical University of South Carolina	Charleston	South Carolina	29425	—
Lisa Lancaster	Nashville	Tennessee	37204	—
University of Texas Southwestern	Dallas	Texas	75390	—
University of Texas Health San Antonio	San Antonio	Texas	78229	—
University of Utah Health	Salt Lake City	Utah	84108	—
University of Virginia	Charlottesville	Virginia	22908	—
University of Washington	Seattle	Washington	98195	—

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04300920, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 20, 2026 · Synced Nov 14, 2026