TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers
Public ClinicalTrials.gov record NCT04306900. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 1/1b Study to Evaluate the Safety and Activity of TTX-030 (Anti-CD39) in Combination With Pembrolizumab or Budigalimab and/or Chemotherapy in Subjects With Advanced Solid Tumors
Study identification
- NCT ID
- NCT04306900
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Trishula Therapeutics, Inc.
- Industry
- Enrollment
- 185 participants
Conditions and interventions
Conditions
Interventions
- Budigalimab and mFOLFOX6 Combination Product
- TTX-030 and budigalimab Combination Product
- TTX-030 and mFOLFOX6 Combination Product
- TTX-030 and pembrolizumab Combination Product
- TTX-030, budigalimab and docetaxel Combination Product
- TTX-030, budigalimab and mFOLFOX6 Combination Product
- TTX-030, budigalimab, nab-paclitaxel and gemcitabine Combination Product
- TTX-030, nab-paclitaxel and gemcitabine Combination Product
Combination Product
Eligibility (public fields only)
- Age range
- 18 Years to 110 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 29, 2020
- Primary completion
- Nov 29, 2022
- Completion
- Mar 26, 2024
- Last update posted
- Jul 28, 2025
2020 – 2024
United States locations
- U.S. sites
- 26
- U.S. states
- 17
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth Research Institute | Scottsdale | Arizona | 85258 | — |
| City of Hope Medical Center Clinical Trials Office | Duarte | California | 91010 | — |
| University of Southern California | Los Angeles | California | 90007 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA Hematology/Oncology | Los Angeles | California | 90404 | — |
| Chao Family Comprehensive CC, UCI | Orange | California | 92868 | — |
| UC Davis Comprehensive Cancer Center | Sacramento | California | 95817 | — |
| Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Ocala Oncology Center PL | Ocala | Florida | 34474 | — |
| Orlando Health UF Health Cancer Center | Orlando | Florida | 32835 | — |
| IACT Health - John B. Amos Cancer Center | Columbus | Georgia | 31904 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40202 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Nebraska Cancer Center Oncology Hematology West P.C. | Omaha | Nebraska | 68130 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44122 | — |
| University of Toledo | Toledo | Ohio | 43614 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Prisma-Health Cancer Institute | Greenville | South Carolina | 29605 | — |
| West Cancer Center and Research Institute | Germantown | Tennessee | 38138 | — |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | — |
| NEXT Oncology | San Antonio | Texas | 78229 | — |
| Hunstman Cancer Intitute | Salt Lake City | Utah | 84112 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Froedtert Hospital & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04306900, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 28, 2025 · Synced May 12, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04306900 live on ClinicalTrials.gov.