ClinicalTrials.gov record
Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)
ClinicalTrials.gov ID: NCT04315324
Public ClinicalTrials.gov record NCT04315324. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/II Study of AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This phase I/II trial studies the safety, side effects and best dose of OBI-3424 and how well it works in treating patients with T-cell acute lymphoblastic leukemia or T-cell lymphoblastic lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Chemotherapy drugs, such as OBI-3424, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. OBI-3424 may reduce the amount of leukemia in the body.
Study identification
- NCT ID
- NCT04315324
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 67 participants
Conditions and interventions
Conditions
Interventions
- AKR1C3-activated Prodrug AST-3424 Drug
- Biopsy Procedure Procedure
- Biospecimen Collection Procedure
- Bone Marrow Aspiration Procedure
- Computed Tomography Procedure
Drug · Procedure
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 7, 2021
- Primary completion
- Oct 27, 2025
- Completion
- Jul 31, 2028
- Last update posted
- Aug 31, 2026
2021 – 2028
United States locations
- U.S. sites
- 163
- U.S. states
- 33
- U.S. cities
- 97
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham Cancer Center | Birmingham | Alabama | 35233 | — |
| Kingman Regional Medical Center | Kingman | Arizona | 86401 | — |
| Arkansas Children's Hospital | Little Rock | Arkansas | 72202-3591 | — |
| PCR Oncology | Arroyo Grande | California | 93420 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Loma Linda University Medical Center | Loma Linda | California | 92354 | — |
| Children's Hospital of Orange County | Orange | California | 92868 | — |
| Children's Hospital Colorado | Aurora | Colorado | 80045 | — |
| Alfred I duPont Hospital for Children | Wilmington | Delaware | 19803 | — |
| Golisano Children's Hospital of Southwest Florida | Fort Myers | Florida | 33908 | — |
| Memorial Regional Hospital/Joe DiMaggio Children's Hospital | Hollywood | Florida | 33021 | — |
| Johns Hopkins All Children's Hospital | St. Petersburg | Florida | 33701 | — |
| Emory University Hospital/Winship Cancer Institute | Atlanta | Georgia | 30322 | — |
| Children's Healthcare of Atlanta - Arthur M Blank Hospital | Atlanta | Georgia | 30329 | — |
| Augusta University Medical Center | Augusta | Georgia | 30912 | — |
| Loyola Center for Health at Burr Ridge | Burr Ridge | Illinois | 60527 | — |
| Lurie Children's Hospital-Chicago | Chicago | Illinois | 60611 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Illinois | Chicago | Illinois | 60612 | — |
| University of Chicago Comprehensive Cancer Center | Chicago | Illinois | 60637 | — |
| Loyola Medicine Homer Glen | Homer Glen | Illinois | 60491 | — |
| Northwestern Medicine Lake Forest Hospital | Lake Forest | Illinois | 60045 | — |
| Loyola University Medical Center | Maywood | Illinois | 60153 | — |
| Marjorie Weinberg Cancer Center at Loyola-Gottlieb | Melrose Park | Illinois | 60160 | — |
| UC Comprehensive Cancer Center at Silver Cross | New Lenox | Illinois | 60451 | — |
| University of Chicago Medicine-Orland Park | Orland Park | Illinois | 60462 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Mary Greeley Medical Center | Ames | Iowa | 50010 | — |
| McFarland Clinic - Ames | Ames | Iowa | 50010 | — |
| McFarland Clinic - Boone | Boone | Iowa | 50036 | — |
| McFarland Clinic - Trinity Cancer Center | Fort Dodge | Iowa | 50501 | — |
| McFarland Clinic - Jefferson | Jefferson | Iowa | 50129 | — |
| McFarland Clinic - Marshalltown | Marshalltown | Iowa | 50158 | — |
| Norton Children's Hospital | Louisville | Kentucky | 40202 | — |
| LSU Health Baton Rouge-North Clinic | Baton Rouge | Louisiana | 70805 | — |
| Our Lady of the Lake Physician Group | Baton Rouge | Louisiana | 70808 | — |
| Johns Hopkins University/Sidney Kimmel Cancer Center | Baltimore | Maryland | 21287 | — |
| Bronson Battle Creek | Battle Creek | Michigan | 49017 | — |
| Wayne State University/Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Weisberg Cancer Treatment Center | Farmington Hills | Michigan | 48334 | — |
| Corewell Health Grand Rapids Hospitals - Butterworth Hospital | Grand Rapids | Michigan | 49503 | — |
| Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital | Grand Rapids | Michigan | 49503 | — |
| Trinity Health Grand Rapids Hospital | Grand Rapids | Michigan | 49503 | — |
| Bronson Methodist Hospital | Kalamazoo | Michigan | 49007 | — |
| West Michigan Cancer Center | Kalamazoo | Michigan | 49007 | — |
| Beacon Kalamazoo Cancer Center | Kalamazoo | Michigan | 49009 | — |
| Beacon Kalamazoo | Kalamazoo | Michigan | 49048 | — |
| Trinity Health Muskegon Hospital | Muskegon | Michigan | 49444 | — |
| Corewell Health Lakeland Hospitals - Niles Hospital | Niles | Michigan | 49120 | — |
| Cancer and Hematology Centers of Western Michigan - Norton Shores | Norton Shores | Michigan | 49444 | — |
| Corewell Health Reed City Hospital | Reed City | Michigan | 49677 | — |
| Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center | Saint Joseph | Michigan | 49085 | — |
| Corewell Health Lakeland Hospitals - Saint Joseph Hospital | Saint Joseph | Michigan | 49085 | — |
| Munson Medical Center | Traverse City | Michigan | 49684 | — |
| University of Michigan Health - West | Wyoming | Michigan | 49519 | — |
| Fairview Ridges Hospital | Burnsville | Minnesota | 55337 | — |
| Minnesota Oncology - Burnsville | Burnsville | Minnesota | 55337 | — |
| Cambridge Medical Center | Cambridge | Minnesota | 55008 | — |
| Mercy Hospital | Coon Rapids | Minnesota | 55433 | — |
| Fairview Southdale Hospital | Edina | Minnesota | 55435 | — |
| Unity Hospital | Fridley | Minnesota | 55432 | — |
| Fairview Clinics and Surgery Center Maple Grove | Maple Grove | Minnesota | 55369 | — |
| Minnesota Oncology Hematology PA-Maplewood | Maplewood | Minnesota | 55109 | — |
| Saint John's Hospital - Healtheast | Maplewood | Minnesota | 55109 | — |
| Abbott-Northwestern Hospital | Minneapolis | Minnesota | 55407 | — |
| Hennepin County Medical Center | Minneapolis | Minnesota | 55415 | — |
| Health Partners Inc | Minneapolis | Minnesota | 55454 | — |
| University of Minnesota/Masonic Cancer Center | Minneapolis | Minnesota | 55455 | — |
| Monticello Cancer Center | Monticello | Minnesota | 55362 | — |
| New Ulm Medical Center | New Ulm | Minnesota | 56073 | — |
| Fairview Northland Medical Center | Princeton | Minnesota | 55371 | — |
| North Memorial Medical Health Center | Robbinsdale | Minnesota | 55422 | — |
| Park Nicollet Clinic - Saint Louis Park | Saint Louis Park | Minnesota | 55416 | — |
| Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| United Hospital | Saint Paul | Minnesota | 55102 | — |
| Saint Francis Regional Medical Center | Shakopee | Minnesota | 55379 | — |
| Lakeview Hospital | Stillwater | Minnesota | 55082 | — |
| Ridgeview Medical Center | Waconia | Minnesota | 55387 | — |
| Rice Memorial Hospital | Willmar | Minnesota | 56201 | — |
| Minnesota Oncology Hematology PA-Woodbury | Woodbury | Minnesota | 55125 | — |
| Fairview Lakes Medical Center | Wyoming | Minnesota | 55092 | — |
| Children's Mercy Hospitals and Clinics | Kansas City | Missouri | 64108 | — |
| Children's Hospital and Medical Center of Omaha | Omaha | Nebraska | 68114 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Carson Tahoe Regional Medical Center | Carson City | Nevada | 89703 | — |
| Cancer and Blood Specialists-Henderson | Henderson | Nevada | 89052 | — |
| Comprehensive Cancer Centers of Nevada - Henderson | Henderson | Nevada | 89052 | — |
| Comprehensive Cancer Centers of Nevada-Horizon Ridge | Henderson | Nevada | 89052 | — |
| Las Vegas Cancer Center-Henderson | Henderson | Nevada | 89052 | — |
| OptumCare Cancer Care at Seven Hills | Henderson | Nevada | 89052 | — |
| Comprehensive Cancer Centers of Nevada-Southeast Henderson | Henderson | Nevada | 89074 | — |
| GenesisCare USA - Henderson | Henderson | Nevada | 89074 | — |
| Las Vegas Urology - Green Valley | Henderson | Nevada | 89074 | — |
| Las Vegas Urology - Pebble | Henderson | Nevada | 89074 | — |
| Urology Specialists of Nevada - Green Valley | Henderson | Nevada | 89074 | — |
| Las Vegas Urology - Pecos | Las Vegas | Nevada | 89074 | — |
| Desert West Surgery | Las Vegas | Nevada | 89102 | — |
| OptumCare Cancer Care at Charleston | Las Vegas | Nevada | 89102 | — |
| University Medical Center of Southern Nevada | Las Vegas | Nevada | 89102 | — |
| Hope Cancer Care of Nevada | Las Vegas | Nevada | 89103 | — |
| Radiation Oncology Centers of Nevada Central | Las Vegas | Nevada | 89106 | — |
| Urology Specialists of Nevada - Central | Las Vegas | Nevada | 89106 | — |
| GenesisCare USA - Las Vegas | Las Vegas | Nevada | 89109 | — |
| HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway | Las Vegas | Nevada | 89109 | — |
| Sunrise Hospital and Medical Center | Las Vegas | Nevada | 89109 | — |
| HealthCare Partners Medical Group Oncology/Hematology-San Martin | Las Vegas | Nevada | 89113 | — |
| Las Vegas Prostate Cancer Center | Las Vegas | Nevada | 89113 | — |
| Las Vegas Urology - Sunset | Las Vegas | Nevada | 89113 | — |
| Urology Specialists of Nevada - Southwest | Las Vegas | Nevada | 89113 | — |
| Radiation Oncology Centers of Nevada Southeast | Las Vegas | Nevada | 89119 | — |
| Ann M Wierman MD LTD | Las Vegas | Nevada | 89128 | — |
| Comprehensive Cancer Centers of Nevada - Northwest | Las Vegas | Nevada | 89128 | — |
| GenesisCare USA - Vegas Tenaya | Las Vegas | Nevada | 89128 | — |
| HealthCare Partners Medical Group Oncology/Hematology-Tenaya | Las Vegas | Nevada | 89128 | — |
| Las Vegas Urology - Cathedral Rock | Las Vegas | Nevada | 89128 | — |
| Las Vegas Urology - Smoke Ranch | Las Vegas | Nevada | 89128 | — |
| OptumCare Cancer Care at MountainView | Las Vegas | Nevada | 89128 | — |
| Urology Specialists of Nevada - Northwest | Las Vegas | Nevada | 89128 | — |
| Alliance for Childhood Diseases/Cure 4 the Kids Foundation | Las Vegas | Nevada | 89135 | — |
| Comprehensive Cancer Centers of Nevada - Town Center | Las Vegas | Nevada | 89144 | — |
| Comprehensive Cancer Centers of Nevada-Summerlin | Las Vegas | Nevada | 89144 | — |
| Summerlin Hospital Medical Center | Las Vegas | Nevada | 89144 | — |
| Las Vegas Cancer Center-Medical Center | Las Vegas | Nevada | 89148-2405 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | — |
| GenesisCare USA - Fort Apache | Las Vegas | Nevada | 89148 | — |
| OptumCare Cancer Care at Fort Apache | Las Vegas | Nevada | 89148 | — |
| HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills | Las Vegas | Nevada | 89149 | — |
| Comprehensive Cancer Centers of Nevada - Central Valley | Las Vegas | Nevada | 89169 | — |
| University Cancer Center | Las Vegas | Nevada | 89169 | — |
| Hope Cancer Care of Nevada-Pahrump | Pahrump | Nevada | 89048 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Saint Mary's Regional Medical Center | Reno | Nevada | 89503 | — |
| Radiation Oncology Associates | Reno | Nevada | 89509 | — |
| University of New Mexico Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| University of Rochester | Rochester | New York | 14642 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| University of Cincinnati Cancer Center-UC Medical Center | Cincinnati | Ohio | 45219 | — |
| Cincinnati Children's Hospital Medical Center | Cincinnati | Ohio | 45229 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| University of Cincinnati Cancer Center-West Chester | West Chester | Ohio | 45069 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Children's Hospital of Pittsburgh of UPMC | Pittsburgh | Pennsylvania | 15224 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Prisma Health Richland Hospital | Columbia | South Carolina | 29203 | — |
| The Children's Hospital at TriStar Centennial | Nashville | Tennessee | 37203 | — |
| Dell Children's Medical Center of Central Texas | Austin | Texas | 78723 | — |
| El Paso Children's Hospital | El Paso | Texas | 79905 | — |
| Methodist Children's Hospital of South Texas | San Antonio | Texas | 78229 | — |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | — |
| Huntsman Cancer Institute/University of Utah | Salt Lake City | Utah | 84112 | — |
| University of Virginia Cancer Center | Charlottesville | Virginia | 22908 | — |
| Children's Hospital of The King's Daughters | Norfolk | Virginia | 23507 | — |
| VCU Massey Comprehensive Cancer Center | Richmond | Virginia | 23298 | — |
| Overlake Medical Center | Bellevue | Washington | 98004 | — |
| Valley Medical Center | Renton | Washington | 98055 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | — |
| North Star Lodge Cancer Center at Yakima Valley Memorial Hospital | Yakima | Washington | 98902 | — |
| West Virginia University Healthcare | Morgantown | West Virginia | 26506 | — |
| Gundersen Lutheran Medical Center | La Crosse | Wisconsin | 54601 | — |
| Cancer Center of Western Wisconsin | New Richmond | Wisconsin | 54017 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04315324, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 31, 2026 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04315324 live on ClinicalTrials.gov.