Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

ClinicalTrials.gov ID: NCT04315324

Public ClinicalTrials.gov record NCT04315324. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 8:34 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I/II Study of AKR1C3-Activated Prodrug OBI-3424 (OBI-3424) In Patients With Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL)

Study identification

NCT ID: NCT04315324
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: SWOG Cancer Research Network; Network
Enrollment: 67 participants

Conditions and interventions

Conditions

Interventions

AKR1C3-activated Prodrug AST-3424 Drug
Biopsy Procedure Procedure
Biospecimen Collection Procedure
Bone Marrow Aspiration Procedure
Computed Tomography Procedure

Drug · Procedure

Eligibility (public fields only)

Age range: 12 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Feb 7, 2021
Primary completion: Jul 31, 2026
Completion: Jul 31, 2028
Last update posted: Aug 14, 2025

2021 – 2028

United States locations

U.S. sites: 163
U.S. states: 33
U.S. cities: 97

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	35233	Active, not recruiting
Kingman Regional Medical Center	Kingman	Arizona	86401	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202-3591	Recruiting
PCR Oncology	Arroyo Grande	California	93420	Recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
Loma Linda University Medical Center	Loma Linda	California	92354	Recruiting
Children's Hospital of Orange County	Orange	California	92868	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Alfred I duPont Hospital for Children	Wilmington	Delaware	19803	Recruiting
Golisano Children's Hospital of Southwest Florida	Fort Myers	Florida	33908	Recruiting
Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	33021	Recruiting
Johns Hopkins All Children's Hospital	St. Petersburg	Florida	33701	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
Children's Healthcare of Atlanta - Arthur M Blank Hospital	Atlanta	Georgia	30329	Recruiting
Augusta University Medical Center	Augusta	Georgia	30912	Recruiting
Loyola Center for Health at Burr Ridge	Burr Ridge	Illinois	60527	Active, not recruiting
Lurie Children's Hospital-Chicago	Chicago	Illinois	60611	Recruiting
Northwestern University	Chicago	Illinois	60611	Recruiting
University of Illinois	Chicago	Illinois	60612	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Active, not recruiting
Loyola Medicine Homer Glen	Homer Glen	Illinois	60491	Active, not recruiting
Northwestern Medicine Lake Forest Hospital	Lake Forest	Illinois	60045	Active, not recruiting
Loyola University Medical Center	Maywood	Illinois	60153	Active, not recruiting
Marjorie Weinberg Cancer Center at Loyola-Gottlieb	Melrose Park	Illinois	60160	Active, not recruiting
UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	60451	Active, not recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Active, not recruiting
Southern Illinois University School of Medicine	Springfield	Illinois	62702	Recruiting
Mary Greeley Medical Center	Ames	Iowa	50010	Recruiting
McFarland Clinic - Ames	Ames	Iowa	50010	Recruiting
McFarland Clinic - Boone	Boone	Iowa	50036	Recruiting
McFarland Clinic - Trinity Cancer Center	Fort Dodge	Iowa	50501	Recruiting
McFarland Clinic - Jefferson	Jefferson	Iowa	50129	Recruiting
McFarland Clinic - Marshalltown	Marshalltown	Iowa	50158	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	70805	Recruiting
Our Lady of the Lake Physician Group	Baton Rouge	Louisiana	70808	Recruiting
Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	21287	Recruiting
Bronson Battle Creek	Battle Creek	Michigan	49017	Recruiting
Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	48201	Active, not recruiting
Weisberg Cancer Treatment Center	Farmington Hills	Michigan	48334	Active, not recruiting
Corewell Health Grand Rapids Hospitals - Butterworth Hospital	Grand Rapids	Michigan	49503	Recruiting
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital	Grand Rapids	Michigan	49503	Recruiting
Trinity Health Grand Rapids Hospital	Grand Rapids	Michigan	49503	Recruiting
Bronson Methodist Hospital	Kalamazoo	Michigan	49007	Recruiting
West Michigan Cancer Center	Kalamazoo	Michigan	49007	Recruiting
Beacon Kalamazoo Cancer Center	Kalamazoo	Michigan	49009	Recruiting
Beacon Kalamazoo	Kalamazoo	Michigan	49048	Recruiting
Trinity Health Muskegon Hospital	Muskegon	Michigan	49444	Recruiting
Corewell Health Lakeland Hospitals - Niles Hospital	Niles	Michigan	49120	Recruiting
Cancer and Hematology Centers of Western Michigan - Norton Shores	Norton Shores	Michigan	49444	Recruiting
Corewell Health Reed City Hospital	Reed City	Michigan	49677	Recruiting
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center	Saint Joseph	Michigan	49085	Recruiting
Corewell Health Lakeland Hospitals - Saint Joseph Hospital	Saint Joseph	Michigan	49085	Recruiting
Munson Medical Center	Traverse City	Michigan	49684	Recruiting
University of Michigan Health - West	Wyoming	Michigan	49519	Recruiting
Fairview Ridges Hospital	Burnsville	Minnesota	55337	Active, not recruiting
Minnesota Oncology - Burnsville	Burnsville	Minnesota	55337	Active, not recruiting
Cambridge Medical Center	Cambridge	Minnesota	55008	Active, not recruiting
Mercy Hospital	Coon Rapids	Minnesota	55433	Active, not recruiting
Fairview Southdale Hospital	Edina	Minnesota	55435	Active, not recruiting
Unity Hospital	Fridley	Minnesota	55432	Active, not recruiting
Fairview Clinics and Surgery Center Maple Grove	Maple Grove	Minnesota	55369	Active, not recruiting
Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	55109	Active, not recruiting
Saint John's Hospital - Healtheast	Maplewood	Minnesota	55109	Active, not recruiting
Abbott-Northwestern Hospital	Minneapolis	Minnesota	55407	Active, not recruiting
Hennepin County Medical Center	Minneapolis	Minnesota	55415	Active, not recruiting
Health Partners Inc	Minneapolis	Minnesota	55454	Active, not recruiting
University of Minnesota/Masonic Cancer Center	Minneapolis	Minnesota	55455	Recruiting
Monticello Cancer Center	Monticello	Minnesota	55362	Active, not recruiting
New Ulm Medical Center	New Ulm	Minnesota	56073	Active, not recruiting
Fairview Northland Medical Center	Princeton	Minnesota	55371	Active, not recruiting
North Memorial Medical Health Center	Robbinsdale	Minnesota	55422	Active, not recruiting
Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	55416	Active, not recruiting
Regions Hospital	Saint Paul	Minnesota	55101	Active, not recruiting
United Hospital	Saint Paul	Minnesota	55102	Active, not recruiting
Saint Francis Regional Medical Center	Shakopee	Minnesota	55379	Active, not recruiting
Lakeview Hospital	Stillwater	Minnesota	55082	Active, not recruiting
Ridgeview Medical Center	Waconia	Minnesota	55387	Active, not recruiting
Rice Memorial Hospital	Willmar	Minnesota	56201	Active, not recruiting
Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	55125	Active, not recruiting
Fairview Lakes Medical Center	Wyoming	Minnesota	55092	Active, not recruiting
Children's Mercy Hospitals and Clinics	Kansas City	Missouri	64108	Recruiting
Children's Hospital and Medical Center of Omaha	Omaha	Nebraska	68114	Recruiting
University of Nebraska Medical Center	Omaha	Nebraska	68198	Recruiting
Carson Tahoe Regional Medical Center	Carson City	Nevada	89703	Recruiting
Cancer and Blood Specialists-Henderson	Henderson	Nevada	89052	Recruiting
Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	89052	Recruiting
Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	89052	Recruiting
Las Vegas Cancer Center-Henderson	Henderson	Nevada	89052	Suspended
OptumCare Cancer Care at Seven Hills	Henderson	Nevada	89052	Recruiting
Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	89074	Recruiting
GenesisCare USA - Henderson	Henderson	Nevada	89074	Recruiting
Las Vegas Urology - Green Valley	Henderson	Nevada	89074	Recruiting
Las Vegas Urology - Pebble	Henderson	Nevada	89074	Recruiting
Urology Specialists of Nevada - Green Valley	Henderson	Nevada	89074	Recruiting
Las Vegas Urology - Pecos	Las Vegas	Nevada	89074	Recruiting
Desert West Surgery	Las Vegas	Nevada	89102	Suspended
OptumCare Cancer Care at Charleston	Las Vegas	Nevada	89102	Recruiting
University Medical Center of Southern Nevada	Las Vegas	Nevada	89102	Recruiting
Hope Cancer Care of Nevada	Las Vegas	Nevada	89103	Recruiting
Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	89106	Recruiting
Urology Specialists of Nevada - Central	Las Vegas	Nevada	89106	Recruiting
GenesisCare USA - Las Vegas	Las Vegas	Nevada	89109	Recruiting
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	89109	Suspended
Sunrise Hospital and Medical Center	Las Vegas	Nevada	89109	Recruiting
HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	89113	Suspended
Las Vegas Prostate Cancer Center	Las Vegas	Nevada	89113	Recruiting
Las Vegas Urology - Sunset	Las Vegas	Nevada	89113	Recruiting
Urology Specialists of Nevada - Southwest	Las Vegas	Nevada	89113	Recruiting
Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	89119	Recruiting
Ann M Wierman MD LTD	Las Vegas	Nevada	89128	Recruiting
Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	89128	Recruiting
GenesisCare USA - Vegas Tenaya	Las Vegas	Nevada	89128	Recruiting
HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	89128	Suspended
Las Vegas Urology - Cathedral Rock	Las Vegas	Nevada	89128	Recruiting
Las Vegas Urology - Smoke Ranch	Las Vegas	Nevada	89128	Recruiting
OptumCare Cancer Care at MountainView	Las Vegas	Nevada	89128	Recruiting
Urology Specialists of Nevada - Northwest	Las Vegas	Nevada	89128	Recruiting
Alliance for Childhood Diseases/Cure 4 the Kids Foundation	Las Vegas	Nevada	89135	Recruiting
Comprehensive Cancer Centers of Nevada - Town Center	Las Vegas	Nevada	89144	Recruiting
Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	89144	Recruiting
Summerlin Hospital Medical Center	Las Vegas	Nevada	89144	Recruiting
Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	89148-2405	Suspended
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89148	Recruiting
GenesisCare USA - Fort Apache	Las Vegas	Nevada	89148	Recruiting
OptumCare Cancer Care at Fort Apache	Las Vegas	Nevada	89148	Recruiting
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	89149	Suspended
Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	89169	Recruiting
University Cancer Center	Las Vegas	Nevada	89169	Recruiting
Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	89048	Recruiting
Renown Regional Medical Center	Reno	Nevada	89502	Recruiting
Saint Mary's Regional Medical Center	Reno	Nevada	89503	Recruiting
Radiation Oncology Associates	Reno	Nevada	89509	Recruiting
University of New Mexico Cancer Center	Albuquerque	New Mexico	87106	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Active, not recruiting
University of Rochester	Rochester	New York	14642	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Cleveland Clinic Foundation	Cleveland	Ohio	44195	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Suspended
Oregon Health and Science University	Portland	Oregon	97239	Active, not recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
Children's Hospital of Pittsburgh of UPMC	Pittsburgh	Pennsylvania	15224	Recruiting
Rhode Island Hospital	Providence	Rhode Island	02903	Recruiting
Prisma Health Richland Hospital	Columbia	South Carolina	29203	Recruiting
The Children's Hospital at TriStar Centennial	Nashville	Tennessee	37203	Recruiting
Dell Children's Medical Center of Central Texas	Austin	Texas	78723	Recruiting
El Paso Children's Hospital	El Paso	Texas	79905	Recruiting
Methodist Children's Hospital of South Texas	San Antonio	Texas	78229	Recruiting
University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Recruiting
Children's Hospital of The King's Daughters	Norfolk	Virginia	23507	Recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
Overlake Medical Center	Bellevue	Washington	98004	Suspended
Valley Medical Center	Renton	Washington	98055	Recruiting
Fred Hutchinson Cancer Center	Seattle	Washington	98109	Recruiting
University of Washington Medical Center - Montlake	Seattle	Washington	98195	Recruiting
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	98902	Recruiting
West Virginia University Healthcare	Morgantown	West Virginia	26506	Recruiting
Gundersen Lutheran Medical Center	La Crosse	Wisconsin	54601	Active, not recruiting
Cancer Center of Western Wisconsin	New Richmond	Wisconsin	54017	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04315324, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 14, 2025 · Synced Apr 29, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04315324 live on ClinicalTrials.gov.

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