ClinicalTrials.gov record
Metabolic Interventions to Resolve Non-alcoholic Steatohepatitis (NASH) With Fibrosis (MIRNA)
ClinicalTrials.gov ID: NCT04321031
Public ClinicalTrials.gov record NCT04321031. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, PLACEBO-CONTROLLED, DOSE-RANGING, DOSE-FINDING, PARALLEL GROUP STUDY TO ASSESS EFFICACY AND SAFETY OF PF-06865571 (DGAT2I) ALONE AND WHEN COADMINISTERED WITH PF-05221304 (ACCI) IN ADULT PARTICIPANTS WITH BIOPSY-CONFIRMED NONALCOHOLIC STEATOHEPATITIS AND FIBROSIS STAGE 2 OR 3
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The study aims to evaluate two, orally administered, investigational agents - PF-06865571 (DGAT2 inhibitor) and the coadministration of PF-06865571 with PF-05221304 (ACC inhibitor). This study is specifically designed to evaluate the effect of a range of doses of DGAT2i alone, and DGAT2i + ACCi, on resolution of NASH or improvement in liver fibrosis, as assessed histologically (via liver biopsy).
Study identification
- NCT ID
- NCT04321031
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 256 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 15, 2020 (Actual)
- Primary completion
- Jan 23, 2024 (Actual)
- Completion
- Feb 21, 2024 (Actual)
- Last update posted
- Mar 21, 2025
2020 – 2024
United States locations
- U.S. sites
- 184
- U.S. states
- 28
- U.S. cities
- 104
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Institute for Liver Health dba Arizona Liver Health | Chandler | Arizona | 85224 | — |
| Comprehensive Interventional Care Centers (CICC) | Gilbert | Arizona | 85233 | — |
| The Institute for Liver Health | Glendale | Arizona | 85306 | — |
| The Institute for Liver Health | Peoria | Arizona | 85381 | — |
| Comprehensive Interventional Care Centers (CICC) | Sun City | Arizona | 85351 | — |
| Institute for Liver Health DBA Arizona Liver Health | Tucson | Arizona | 85712 | — |
| Hope Clinical Research | Canoga Park | California | 91303 | — |
| Sharp Coronado Hospital | Coronado | California | 92118 | — |
| Southern California Research Center | Coronado | California | 92118 | — |
| Magnolia Surgery Center | El Cajon | California | 92020 | — |
| Encino Hospital Medical Center | Encino | California | 91436 | — |
| National Research Institute | Huntington Park | California | 90255 | — |
| Investigational Drug Service, Altman Clinical and Translational Research Institute (ACTRI) | La Jolla | California | 92037 | — |
| University of California San Diego, Altman Clinical and Translational Research Institute Clinic | La Jolla | California | 92037 | — |
| UCSD Altman Clinical and Transitional Research Institute | La Jolla | California | 92093 | — |
| A V Pediatrics, Allergy & Family Medicine | Lancaster | California | 93534 | — |
| Jatinder S. Pruthi, M.D. FACG CPI | Lancaster | California | 93534 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Cedars-Sinai Advanced Health Sciences Pavilion (Imaging) | Los Angeles | California | 90048 | — |
| Cedars-Sinai Comprehensive Transplant Center | Los Angeles | California | 90048 | — |
| Cedars-Sinai Medical Center Investigational Drug Services (Pharmacy) | Los Angeles | California | 90048 | — |
| S. Mark Taper Foundation Imaging Center (Liver Biopsy) | Los Angeles | California | 90048 | — |
| Providence Facey Medical Foundation | Mission Hills | California | 91345 | — |
| Providence Holy Cross Medical Center | Mission Hills | California | 91345 | — |
| ART Vascular | Montebello | California | 90640 | — |
| United Medical Doctors | Murrieta | California | 92563 | — |
| Back Bay Imaging (Liver Biopsy) | Newport Beach | California | 92660 | — |
| Advanced Imaging Center | Palmdale | California | 93551 | — |
| Blake Wilbur Outpatient Clinic (MRI) | Palo Alto | California | 94304 | — |
| Stanford Hospital and Clinics | Palo Alto | California | 94305 | — |
| California Liver Research Institute | Pasadena | California | 91105 | — |
| HMRI | Pasadena | California | 91105 | — |
| Stanford Medicine Outpatient Center (Liver clinic/MRI) | Redwood City | California | 94063 | — |
| Inland Empire Clinical Trials, LLC | Rialto | California | 92377 | — |
| Clinical Trials Research | Sacramento | California | 95821 | — |
| Precision Research Institute | San Diego | California | 92114 | — |
| WR-MCCR | San Diego | California | 92120 | — |
| Sharp and Children's MRI Center, LLC | San Diego | California | 92123 | — |
| Stanford Cancer Center South Bay (MRI) | San Jose | California | 95124 | — |
| Liberty Pacific Advanced Imaging | Tarzana | California | 91356 | — |
| Orange County Research Center | Tustin | California | 92780 | — |
| Upland Clinical Research | Upland | California | 91786 | — |
| Bristol Hospital | Bristol | Connecticut | 06010 | — |
| Bristol Radiology Center | Bristol | Connecticut | 06010 | — |
| Connecticut Clinical Research Institute, LLC | Bristol | Connecticut | 06010 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Yale New Haven Hospital, Saint Raphael Campus (MRE location) | New Haven | Connecticut | 06511 | — |
| Yale Center for Clinical Investigators, Church Street South Research Unit (CSRU) | New Haven | Connecticut | 06519 | — |
| Yale Digestive Diseases (Fibroscan location) | New Haven | Connecticut | 06520 | — |
| Tower Radiology (MRI-PDFF) | Brandon | Florida | 33511 | — |
| Tower Radiology - Parsons | Brandon | Florida | 33511 | — |
| Gastro Florida | Clearwater | Florida | 33756 | — |
| Gastro Florida | Clearwater | Florida | 33762 | — |
| Integrity Clinical Research, LLC | Doral | Florida | 33122 | — |
| Mayo Clinic Florida | Jacksonville | Florida | 32224 | — |
| Florida Research Institute | Lakewood Rch | Florida | 34211 | — |
| Center for Advanced Gastroenterology | Maitland | Florida | 32751 | — |
| Sandlake Imaging | Maitland | Florida | 32751 | — |
| Optimus U Corporation | Miami | Florida | 33125 | — |
| Unique Imaging (Biscayne Imaging Center) | Miami | Florida | 33137 | — |
| Acevedo Clinical Research Associates | Miami | Florida | 33142 | — |
| Ivetmar Medical Group LLC | Miami | Florida | 33155 | — |
| Vascular and Interventional Specialists of Florida (Liver Biopsy) | Miami | Florida | 33156 | — |
| Care Research Center Inc | Miami | Florida | 33175 | — |
| San Marcus Research Clinic, Inc. | Miami Lakes | Florida | 33014 | — |
| TGH Imaging Powered by Tower Radiology Center (MRI) | Oldsmar | Florida | 34677 | — |
| Clinical Neuroscience Solutions, Inc | Orlando | Florida | 32801 | — |
| Omega Research Maitland, LLC | Orlando | Florida | 32808 | — |
| Innovation Medical Research Center, Inc | Palmetto Bay | Florida | 33157 | — |
| Partners Imaging Center | Sarasota | Florida | 34239 | — |
| GCP, Global Clinical Professionals | St. Petersburg | Florida | 33702 | — |
| Gateway (Ultrasound) | St. Petersburg | Florida | 33712 | — |
| Radiology Associates | Tampa | Florida | 33606 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| AdventHealth Zephyrhills | Zephyrhills | Florida | 33541 | — |
| Florida Medical Clinic, LLC | Zephyrhills | Florida | 33542 | — |
| Digestive Healthcare of Georgia | Atlanta | Georgia | 30309 | — |
| Piedmont Atlanta Hospital/Piedmont Transplant Institute | Atlanta | Georgia | 30309 | — |
| Piedmont Atlanta Hospital | Atlanta | Georgia | 30309 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| WR-Mount Vernon Clinical Research, LLC | Sandy Springs | Georgia | 30328 | — |
| Tekton Research, Inc. | Snellville | Georgia | 30078 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Investigators Research Group, LLC | Brownsburg | Indiana | 46112 | — |
| Hendricks Regional Health | Hendricks | Indiana | 46122 | — |
| Heartland Medical Research, Inc. (Administrative Only) | Clive | Iowa | 50325 | — |
| Iowa Digestive Disease Center | Clive | Iowa | 50325 | — |
| Iowa Radiology | Clive | Iowa | 50325 | — |
| MercyOne Des Moines Medical Center (Mercy Medical Center) | Des Moines | Iowa | 50314 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Iowa Magnetic Resonance Research Facility | Iowa City | Iowa | 52242 | — |
| Kansas Medical Clinic PA | Topeka | Kansas | 66606 | — |
| Alliance for Multispecialty Research, LLC | Wichita | Kansas | 67205 | — |
| Cypress Interventional | Wichita | Kansas | 67226 | — |
| Centex Studies, Inc. | Lake Charles | Louisiana | 70601 | — |
| Lake Charles Memorial Hospital | Lake Charles | Louisiana | 70601 | — |
| Metropolitan Gastroenterology Associates | Marrero | Louisiana | 70072 | — |
| Tandem Clinical Research GI, LLC | Marrero | Louisiana | 70072 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Louisiana Research Center, LLC | Shreveport | Louisiana | 71105 | — |
| Gastro Health Research | Catonsville | Maryland | 21228 | — |
| Gastro Center of Maryland | Columbia | Maryland | 21045 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Michigan Clinical Research Unit (MCRU) | Ann Arbor | Michigan | 48109 | — |
| University of Michigan | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Aa Mrc Llc | Flint | Michigan | 48504 | — |
| Mercy Health | Grand Rapids | Michigan | 49503 | — |
| M1 Imaging Center | Grand Rapids | Michigan | 49505 | — |
| Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center | Wyoming | Michigan | 49519 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Jefferson City Medical Group, P.C. | Jefferson City | Missouri | 65109 | — |
| Desert Radiology | Las Vegas | Nevada | 89104 | — |
| Machuca Family Medicine | Las Vegas | Nevada | 89104 | — |
| The Machuca Foundation, Inc. | Las Vegas | Nevada | 89104 | — |
| Sierra Clinical Research | Las Vegas | Nevada | 89106 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| Pueblo Medical Imaging | Las Vegas | Nevada | 89118 | — |
| Digestive Healthcare Associates | Hillsborough | New Jersey | 08844 | — |
| University Radiology | Hillsborough | New Jersey | 08844 | — |
| Amici Clinical Research | Raritan | New Jersey | 08869 | — |
| Northwell Health Center for Liver Diseases | Manhasset | New York | 11030 | — |
| Icahn School of Medicine at Mount Sinai/The Mount Sinai Hospital | New York | New York | 10029 | — |
| M3 - Wake Research, Inc. | Raleigh | North Carolina | 27612 | — |
| Gastroenterology Associates of the Piedmont, PA | Winston-Salem | North Carolina | 27103 | — |
| Novant Health Medical Center | Winston-Salem | North Carolina | 27103 | — |
| PMG Research of Winston-Salem, LLC | Winston-Salem | North Carolina | 27103 | — |
| Paramount Medical Research & Consulting, LLC | Middleburg Heights | Ohio | 44130 | — |
| Comprehensive Diagnostic Imaging | Oklahoma City | Oklahoma | 73112 | — |
| Digestive Disease Specialists, Inc. Endoscopy Lab | Oklahoma City | Oklahoma | 73112 | — |
| Digestive Disease Specialists, Inc. | Oklahoma City | Oklahoma | 73112 | — |
| Oklahoma Spine Hospital | Oklahoma City | Oklahoma | 73134 | — |
| Thomas Jefferson University | Philadelphia | Pennsylvania | 19107 | — |
| UPMC - Center for Liver Diseases at the Thomas E. Starzl Institute | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC - Center for Liver Diseases in the Digestive Disorders Clinic | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC - Translational Research Center | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC Presbyterian Shadyside; Presbyterian Campus Pharmacy | Pittsburgh | Pennsylvania | 15213 | — |
| UPMC | Pittsburgh | Pennsylvania | 15213 | — |
| University Gastroenterology | Providence | Rhode Island | 02905 | — |
| Roger Williams Hospital | Providence | Rhode Island | 02908 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| MUSC- Ashley River Tower | Charleston | South Carolina | 29425 | — |
| Chattanooga Imaging Center | Chattanooga | Tennessee | 37421 | — |
| WR-Clinsearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Quality Medical Research, PLLC | Nashville | Tennessee | 37211 | — |
| Vanderbilt Hepatology and Liver Transplant | Nashville | Tennessee | 37212 | — |
| Vanderbilt University Medical Center - GI Research Office | Nashville | Tennessee | 37212 | — |
| Vanderbilt University Medical Center - Digestive Disease Center | Nashville | Tennessee | 37232 | — |
| Vanderbilt University Medical Center - Heart Station | Nashville | Tennessee | 37232 | — |
| Vanderbilt University Medical Center - Interventional Radiology | Nashville | Tennessee | 37232 | — |
| Texas Center for Interventional Surgery (Liver Biopsy Facility) | Addison | Texas | 75001 | — |
| Texas Clinical Research Institute | Arlington | Texas | 76012 | — |
| Methodist Dallas Medical Center (MRI-PDFF) | Dallas | Texas | 75203 | — |
| The Liver Institute at Methodist Dallas Medical Center | Dallas | Texas | 75203 | — |
| Touchstone Imaging | Dallas | Texas | 75246 | — |
| Center For Diagnostic Imaging | DeSoto | Texas | 75115 | — |
| GI Alliance | Fort Worth | Texas | 76104 | — |
| Therapeutic Concepts, PA | Houston | Texas | 77004 | — |
| Centex Studies, Inc. | Houston | Texas | 77058 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | — |
| Premier Vein and Vascular | Houston | Texas | 77084 | — |
| Centex Studies, Inc | McAllen | Texas | 78504 | — |
| HCA Houston Healthcare Pearland | Pearland | Texas | 77584 | — |
| American Research Corporation at the Texas Liver Institute | San Antonio | Texas | 78215 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Diabetes and Glandular Disease Clinic, P.A. | San Antonio | Texas | 78229 | — |
| Reddy Cardiac Wellness | Sugar Land | Texas | 77479 | — |
| Impact Research Institute | Waco | Texas | 76710 | — |
| Gastro Health Research | Fairfax | Virginia | 22031 | — |
| Gastro Health, LLC | Fairfax | Virginia | 22031 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| Digestive and Liver Disease Specialists | Norfolk | Virginia | 23502 | — |
| Sentara Leigh Hospital | Norfolk | Virginia | 23502 | — |
| McGuire VA Medical Center | Richmond | Virginia | 23249 | — |
| VCU Medical Center Investigational Drug Service | Richmond | Virginia | 23298 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Virginia Gastroenterology Clinical Research | Suffolk | Virginia | 23435 | — |
| Harborview Medical Center Investigational Drug Services | Seattle | Washington | 98104 | — |
| Harborview Medical Center | Seattle | Washington | 98104 | — |
| Seattle Radiology | Seattle | Washington | 98104 | — |
| Liver Institute Northwest | Seattle | Washington | 98105 | — |
| Swedish Medical Center | Seattle | Washington | 98122 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 107 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04321031, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 21, 2025 · Synced Oct 28, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04321031 live on ClinicalTrials.gov.