Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

ClinicalTrials.gov ID: NCT04323046

Public ClinicalTrials.gov record NCT04323046. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 17, 2026, 3:15 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Single Arm, Pilot of Neoadjuvant Checkpoint Inhibition Followed by Adjuvant Checkpoint Inhibition in Children and Young Adults With Recurrent or Progressive High Grade Glioma (HGG)

Study identification

NCT ID: NCT04323046
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Sabine Mueller, MD, PhD; Other
Enrollment: 20 participants

Conditions and interventions

Conditions

Interventions

Nivolumab Biological
Quality-of-Life Assessment Other
Questionnaire Administration Other

Biological · Other

Eligibility (public fields only)

Age range: 6 Months to 25 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 1, 2020
Primary completion: Feb 28, 2026
Completion: Feb 28, 2029
Last update posted: May 3, 2025

2020 – 2029

United States locations

U.S. sites: 14
U.S. states: 12
U.S. cities: 14

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham, Children's of Alabama	Birmingham	Alabama	35233	Recruiting
Children's Hospital of Los Angeles	Los Angeles	California	90027	Recruiting
Rady Children's Hospital	San Diego	California	92123	Recruiting
University of California, San Francisco	San Francisco	California	94115	Recruiting
Children's National Hospital	Washington D.C.	District of Columbia	20310	Recruiting
University of Florida	Gainesville	Florida	32611	Recruiting
Riley Children's Hospital	Indianapolis	Indiana	46202	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Washington University St. Louis	St Louis	Missouri	63110	Recruiting
Hackensack Meridian Children's Health at Joseph M. Sanzari Children's Hospital	Hackensack	New Jersey	07601	Recruiting
Duke Children's Hospital & Health Center	Durham	North Carolina	27705	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
University of Utah	Salt Lake City	Utah	84113	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04323046, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 3, 2025 · Synced May 17, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04323046 live on ClinicalTrials.gov.

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